学习经历

2008/09-2013/06，武汉大学，博士/Wuhan University, PhD

2004/09-2008/06，武汉大学，学士/ Wuhan University, Bachelor's Degree

主要工作经历与任职情况

2015/03-至今：武汉大学生命科学学院/ College of Life Sciences, Wuhan University；副研究员

2013/09-2015/01：美国辛辛那提儿童医院医学中心/Cincinnati Children’s Hospital Medical Center, USA；Research Fellow.

承担课程

本科生：《生物化学技术实验》

主持课题项目

国家科技重大专项子课题

国家自然科学基金青年项目

中央高校基本科研业务费专项资金

发表的论文（#并列第一作者，*通讯作者）：

1. Yang Li, Wei Xi, Jianfeng Hao, Li Zhang, Xingpeng Wen, Zhiguo Wu*, Yuxian Zhu. A Novel Tandem Zinc Finger Protein in Gossypium hirsutum, GhTZF2, Interacts with GhMORF8 to Regulate Cotton Fiber Cell Development. Agronomy, 2023, 13(2), 519.
2. Zhiguo Wu*, Wei Xi, Zixuan Han, Yanhua Wu, Yongzhuo Guan, Yuxian Zhu. Genome-Wide Comparative Analysis of Transposable Elements by Matrix-TE Method Revealed Indica and Japonica Rice Evolution. Agronomy, 2022, 12(7), 1490.
3. Gai Huang^#,Zhiguo Wu^#, Richard G. Percy, Mingzhou Bai, Yang Li, James E. Frelichowski, Jiang Hu, Kun Wang, John Z. Yu*, Yuxian Zhu*. Genome sequence of Gossypium herbaceum, and genome update of Gossypium arboreum and Gossypium hirsutum provide insights into cotton A-genome evolution, Nature Genetics, 2020,52,516-524. (#共同第一作者)
4. Jing Lin, Ying Cai, Gai Huang, Yan Yang, Yang Li, Kun Wang, Zhiguo Wu*. Analysis of the chromatin binding affinity of retrotransposases reveals novel roles in diploid and tetraploid cotton. J Integr Plant Biol, 2019, 61, 32-44.
5. Zhiguo Wu, Yan Yang, Gai Huang, Jing Lin, Yuying Xia, Yuxian Zhu*. Cotton functional genomics reveals global insight into genome evolution and fiber development. Journal of Genetics and Genomics, 2017, 44, 511-518.
6. Virendra Chaudhri, Krista Dienger, Zhiguo Wu, Mahesh Shrestha, Harinder Singh*. Charting the cis-regulome of activated B cells by coupling structural and functional genomics. Nature Immunology, 2020, 21, 2:210-220.
7. Sofia Sirvent, Andres F Vallejo, James Davies, Kalum Clayton, Zhiguo Wu, Jeong min Woo , Jeremy Riddell, Virendra K Chaudhri, Patrick Stumpf , Liliya Angelova Nazlamova, Gabrielle Wheway, Matthew Rose-Zerilli, Jonathan West, Mario Pujato, Xiaoting Chen, Christopher H Woelk, Ben MacArthur, Michael Ardern-Jones, Peter S Friedmann, Matthew T Weirauch, Harinder Singh, Marta E Polak. Genomic programming of IRF4-expressing human Langerhans cells. Nature Communications, 2020, 11, 1:313.
8. Weiwu Zeng, Fan Wu, Chaoxing Liu, Yan Yang, Bingyao Wang, Yushu Yuan, Jiaqi Wang, Yuqi Chen, Boshi Fu, Zhiguo Wu*, Xiang Zhou*. Small-molecule-based human genome G4 profiling reveals potential gene regulation activity. Chem Commun, 2019, 55, 2269-2272.
9. Chen Xu, Jinjun Wu, Wenting Liu, Tingting Hong, Tianlu Wang, Xiaoe Zhang, Boshi Fu, Fan Wu, Zhiguo Wu*, Xiang Zhou*. Detecting 5-methylcytosine using an enzyme-free DNA strand exchange reaction without pretreatment under physiological conditions. Chem Commun, 2016, 52, 6833-6836.
10. Heping Xu, Virendra K Chaudhri, Zhiguo Wu, Konstantinos Biliouris, Krista Dienger-Stambaugh, Yrina Rochman and Harinder Singh*. Regulation of bifurcating B cell trajectories by mutual antagonism between transcription factors IRF4 and IRF8. Nature Immunology, 2015, 16, 1274-1281.
11. Xiaoming Lu, Erin E. Zoller, Matthew T. Weirauch, Zhiguo Wu, Bahram Namjou, Adrienne H. Williams, Julie T. Ziegler, Mary E. Comeau, Miranda C. Marion, Stuart B. Glenn, Adam Adler, Nan Shen, Swapan K. Nath, Anne M. Stevens, Barry I. Freedman, Betty P. Tsao, Chaim O. Jacob, Diane L. Kamen, Elizabeth E. Brown, Gary S. Gilkeson, Graciela S. Alarcón, John D. Reveille, Juan-Manuel Anaya, Judith A. James, Kathy L. Sivils, Lindsey A. Criswell, Luis M. Vilá, Marta E. Alarcón-Riquelme, Michelle Petri, R Hal Scofield, Robert P. Kimberly, Rosalind Ramsey-Goldman, Young Bin Joo, Jeongim Choi, Sang-Cheol Bae, Susan A. Boackle, Deborah Cunninghame Graham, Timothy J. Vyse, Joel M. Guthridge, Patrick M. Gaffney, Carl D. Langefeld, Jennifer A. Kelly, Kenneth D. Greis, Kenneth M. Kaufman, John B. Harley,* Leah C. Kottyan*. Lupus risk-variant increases pSTAT1 binding and decreases ETS1 expression. American Journal of Human Genetics, 2015, 5:731-739.
12. Zhiguo Wu, Xiao Xie, Puzhen Li, Jiayi Zhao, Lili Huang and Xiang Zhou*. Equilibrious Strand Exchange Promoted by DNA Conformational Switching. Scientific Reports, 2013, 3, 1121.
13. Zhiguo Wu, Tian Tian, Junping Yu, Xiaocheng Weng, Yi Liu, and Xiang Zhou*. Formation of Sequence-Independent Z-DNA Induced by a Ruthenium Complex at Low Salt Concentrations. Angew. Chem. Int. Ed., 2011, 50, 11962-11967.
14. Zhiguo Wu, Mingliang Tang, Tian Tian, Jianguo Wu, Yuanlin Deng, Xiaohu Dong, Zheng Tan, Xiaocheng Weng, Zhihong Liu, Chunjiang Wang, Xiang Zhou*. A specific probe for two-photon fluorescence lysosomal imaging. Talanta, 2011,87, 216-221.