学习经历

2008.09-2014.07，中国科学院生物物理研究所，生物物理学专业，理学博士

2004.09-2008.07，德州学院，生物科学专业，理学学士

主要工作经历及任职情况

2023.06至今，武汉大学生命科学学院，副教授

2018.02-2023.04，德州学院生物物理研究院，教授

2014.09-2018.01，德州学院生物物理研究院，讲师

主要研究领域及兴趣

　　以单颗粒冷冻电镜（SPA）、冷冻电子断层成像（cryo-ET）、冷冻聚焦离子束-扫描电镜双束电镜（FIB-SEM）等冷冻电子显微学技术及X射线晶体学为主要技术手段，辅以其他生物物理学和计算生物学方法，主要关注：1）染色质纤维及核小体相关复合物的三维结构，及其在表观遗传调控中的作用机制；2）病原微生物致病性相关复合物的结构生物学研究。此外，还将致力于开发冷冻电子显微学新方法和新技术。

　　近年来解析了包括真核生物30nm染色质纤维、结核分枝杆菌毒力因子分泌相关蛋白EspB及诺维氏梭菌外毒素蛋白Tcn alpha等多个具有重要生物学意义的大分子复合物结构。以第一作者或共同作者身份在Science、Cell、Biophysical Journal等期刊发表多篇研究论文。关于30nm染色质高级结构的研究成果被多本知名结构生物学和生物化学教科书引用，并且入选“中科院十八大以来重大成果”及“中科院十二五标志性重大进展核心成果”。

主要科研奖励和个人荣誉

2018年，30nm染色质纤维结构及其动态调控的分子机制研究，北京市科学技术奖二等奖

2015年，30nm染色质及染色质重塑复合物Tip49a/Tip49b的结构和功能研究，中国科学院优秀博士学位论文

2014年，中国科学院院长特别奖

2012年，Gatan China Scholarship

主持课题项目

山东省泰山学者青年专家计划（tsqn20161049），2017.01-2021.12

国家自然科学基金-青年基金项目（31500606），2016.01-2018.12

山东省自然科学基金-青年基金项目（ZQ2015CQ002），2015.07-2017.07

山东省高等学校科技计划项目（J15LE09），2016.01-2018.12

发表的论文（#并列第一作者，*通讯作者）

1. Jing Liu, Chong Feng, Min Zhang, Feng Song^*, Haochen Liu^*. (2022) Design and Fabrication of a Liver-on-a-chip Reconstructing Tissue-tissue Interfaces, Frontiers in Oncology, 12: 959299.
2. Jian Liu, Kaiquan Liu, Zhe Zhao, Zheng Wang, Fengchao Wang, Yuxiu Xin, Jie Qu, Feng Song^*, Zhenghua Li^*. (2022) The LuxS/AI-2 Quorum-Sensing System Regulates the Algicidal Activity of Shewanella xiamenensis Lzh-2, Frontiers in Microbiology, 12: 814929.
3. Yun-Qiang Bian^*, Feng Song, Zan-Xia Cao, Jia-Feng Yu, Ji-Hua Wang^*. (2021) Structure-based simulations complemented by conventional all-atom simulations to provide new insights into the folding dynamics of human telomeric G-quadruplex, Chinese Physics B, 30 (7): 78702-078702.
4. Wanling Cui^*, Guodong Hu, Feng Song, Rui Wang, Zanxia Cao, Junye Zhang, Tiejun Wang, Fanlu Meng, Congcong Shen, Shicai Xu^*, Jihua Wang^*. (2020) A cascade strand displacement amplification strategy for highly sensitive and label-free detection of DNA methyltransferase activity. Microchemical Journal, 160: 105775.
5. Feng Song^#*,Yunqiang Bian^#, Jing Liu, Zhenghua Li, Li Zhao, Junman Fang, Yonghong Lai, Meng Zhou. (2020) Indole Alkaloids, Synthetic Dimers and Hybrids with Potential In Vivo Anticancer Activity. Current Topics in Medicinal Chemistry, 21(5): 377-403.
6. Feng Song^#*, Zhenghua Li, Yunqiang Bian, Xiankai Huo, Junman Fang, Linlin Shao, Meng Zhou. (2020) Indole/isatin-containing hybrids as potential antibacterial agents. Archiv der Pharmazie, 353 (10): e2000143.
7. Tian Hua^#*, Xiaoting Li^#, Lijie Wu^#, Christos Iliopoulos-Tsoutsouvas, Yuxia Wang, Meng Wu,Ling Shen, Christina A. Johnston, Spyros P. Nikas, Feng Song, Xiyong Song, Shuguang Yuan, Qianqian Sun, Yiran Wu, Shan Jiang, Travis W. Grim, Othman Benchama, Edward L. Stahl, Nikolai Zvonok, Suwen Zhao, Laura M.Bohn, Alexandros Makriyannis, Zhi-Jie Liu^*. (2020) Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-Gi Complex Structures. Cell, 180 (4): 655-665.
8. Yunqiang Bian, Feng Song, Jian Zhang, Jiafeng Yu, Jihua Wang^*, Wei Wang^*. (2020) Insights into the Kinetic Partitioning Folding Dynamics of the Human Telomeric G-Quadruplex from Molecular Simulations and Machine Learning. J. Chem. Theory Comput, 16 (9): 5936-5947.
9. Yunqiang Bian^#*, Feng Song^#, Zanxia Cao, Liling Zhao, Jiafeng Yu, Xinlu Guo, Jihua Wang^*. (2018) Fast folding pathways of the thrombin-binding aptamer G-quadruplex revealed by a Markov state model. Biophysical Journal, 114: 1529-1538.
10. Zhenghua Li, Mei Chen, Kun Ran, Jihua Wang, Qiangcheng Zeng, Feng Song^*. (2018) Draft Genome Sequence of Bacillus velezensis Lzh-a42, a Plant Growth-Promoting Rhizobacterium Isolated from Tomato Rhizosphere. Genome Announcements, 6 (12): e00161-18.
11. Zhenghua Li, Xiaoming Li, Qiangcheng Zeng, Mei Chen, Dan Liu, Jihua Wang, Liang Shen, Feng Song^*. (2018) Genome Sequence of Pseudomonas chlororaphis Lzh-T5, a Plant Growth-Promoting Rhizobacterium with Antimicrobial Activity. Genome Announcements, 6 (18): e00328-18.
12. Yunqiang Bian^*, Weitong Ren, Feng Song, Jiafeng Yu, Jihua Wang^*. (2018) Exploration of the folding dynamics of human telomeric G-quadruplex with a hybrid atomistic structure-based model. The Journal of Chemical Physics, 148 (20): 204107-1-204107-8.
13. Bailing Zhou, Huiying Zhao, Jiafeng Yu, Chengang Guo, Xianghua Dou, Feng Song, Guodong Hu, Zanxia Cao, Yuanxu Qu, Yuedong Yang, Yaoqi Zhou^*, Jihua Wang^*. (2018) EVLncRNAs: a manually curated database for long non-coding RNAs validated by low-throughput experiments. Nucleic Acids Research, 46 (Database issue): D100-D105.
14. Feng Song^#, Ping Chen^#, Dapeng Sun, Mingzhu Wang, Liping Dong, Dan Liang, Rui-ming Xu, Ping Zhu^*, Guohong Li^*. (2014) Cryo-EM study of the chromatin fiber reveals a double helix twisted by tetra-nucleosomal units. Science, 344 (6182): 376-380.
15. Bin Zhu^#, Chongwen Yang^#, Hongrong Liu^*, Lingpeng Cheng^*, Feng Song, Songjun Zeng, Xiaojun Huang, Gang Ji, Ping Zhu. (2014) Identification of the active sites in the methyltransferases of a transcribing dsRNA virus. Journal of Molecular Biology, 426 (11): 2167-2174.
16. Qing Yao^#, Qiuhe Lu^#, Xiaobo Wan, Feng Song, Yue Xu, Mo Hu, Alla Zamyatina, Xiaoyun Liu, Niu Huang, Ping Zhu^*, Feng Shao^*. (2014) A structural mechanism for bacterial autotransporter glycosylation by a dodecameric heptosyltransferase family. eLife, 3: e03714.
17. Dapeng Sun, Feng Song, Li Huang, Kuo Zhang, Gang Ji, Ping Chen^*, Ping Zhu^*. (2013) In vitro assembly and electron microscopic analysis of 30-nm chromatin fibers. Progress in Biochemistry and Biophysics, 40 (8): 739-74.

　　欢迎生物学、物理学、计算机科学、电子学等专业背景，有志于从事交叉学科研究的同学报考硕士研究生。