学习经历
2009/09-2014/07 中国农业大学，微生物，博士学位
2005/09-2009/06 河北科技大学，生物技术，学士学位
主要工作经历与任职情况
2021/03-至今 武汉大学生命科学学院、病毒学国家重点实验室，研究员
2020/01-2021/02 美国圣路易斯华盛顿大学医学院，讲师
2015/02-2019/12 美国圣路易斯华盛顿大学医学院，博士后
主要科研奖励和个人荣誉
2022，武汉市“武汉英才”优秀青年人才
2020，湖北省“BR”计划
主要研究领域及兴趣
病毒感染导致的传染性疾病严重影响了人们的生活和国民经济的发展，B细胞介导的体液免疫反应是机体对抗病毒感染的重要手段之一，也是病毒疫苗发挥作用的重要因素。课题组主要以虫媒病毒以及各种新发与再发传染性病毒为研究对象，结合分子病毒学、细胞生物学、动物免疫学、生物化学和结构生物学等多种技术手段，研究病毒感染诱导的体液免疫应答特点和机制，开发高效保护性抗体药物，并进行抗原的优化设计和疫苗的研发。
主持课题项目
2022-2025, 国家自然科学基金面上项目，主持
2022-2025，国家重点研发计划“生物安全关键技术研究”重点专项子课题，主持
2021-2026，武汉大学“双一流”建设人才启动经费，主持
2024-2026，武汉市自然科学基金探索计划（晨光计划）项目，主持
发表的论文（*通讯作者）
1. Ren X#, Sun J#, Kuang W#, Yu F, Wang B, Wang Y, Deng W, Xu Z, Yang S, Wang H, Hu Y, Deng Z*, Ning YJ*, Zhao H*. A broadly protective antibody targeting glycoprotein Gn inhibits severe fever with thrombocytopenia syndrome virus infection. Nat Commun. 2024; 15(1):7009.
2. Zhou D#, Cheng R#, Yao Y#, Zhang G, Li X, Wang B, Wang Y, Yu F, Yang S, Liu H, Gao G, Peng Y, Chen M, Deng Z*, Zhao H*. An attachment glycoprotein nanoparticle elicits broadly neutralizing antibodies and protects against lethal Nipah virus infection. npj Vaccines. 2024; 9(1):158.
3. Yang S#, Wang Y#, Yu F#, Cheng R, Zhang Y, Zhou D, Ren X, Deng Z*, Zhao H*. Structural and functional insights into the modulation of T cell costimulation by monkeypox virus protein M2. Nat Commun. 2023;14(1):5186.
4. Zhao H, Xu L, Bombardi R, Nargi R, Deng Z, Errico JM, Nelson CA, Dowd KA, Pierson TC, Crowe JE, Diamond MS, Fremont DH*. Mechanism of differential Zika and dengue virus neutralization by a public antibody lineage targeting the DIII lateral ridge. J Exp Med. 2020; 217:e20191792.
5. Zhao H#, Fernandez E#, Dowd KA, Speer SD, Platt DJ, Gorman MJ, Govero J, Nelson CA, Pierson TC, Diamond MS*, Fremont DH*. Structural Basis of Zika Virus-Specific Antibody Protection. Cell. 2016; 166:1016-1027.
6. Liu Q#, Zhao H#, Li Z#, Zhang Z#, Huang R#, Gu M, Zhuang K, Xiong Q, Chen X, Yu W, Qian S, Zhang Y, Tan X, Zhang M, Yu F, Guo M, Huang Z, Wang X, Xiang W, Wu B, Mei F, Cai K, Zhou L, Zhou L, Wu Y*, Yan H*, Cao S*, Lan K*, Chen Y*. Broadly neutralizing antibodies derived from the earliest COVID-19 convalescents protect mice from SARS-CoV-2 variants challenge. Signal Transduct Target Ther. 2023;8(1):347.
7. Errico JM#, Zhao H#, Chen RE, Liu Z, Case JB, Ma MS, Schmitz AJ, Rau MJ, Fitzpatrick JA, Shi PY, Diamond MS, Whelan SPJ, Ellebedy AH, Fremont DH *, 2021. Structural mechanism of SARS-CoV-2 neutralization by two murine antibodies targeting the RBD. Cell Reports.2021;37 (4) 109881.
8. Chapman NS, Zhao H, Kose N, Westover JB, Kalveram B, Bombardi R, Rodriguez J, Sutton R, Genualdi J, Desiree LaBeaud D, Mutuku FM, Pittman PR, Freiberg AN, Gowen BB, Fremont DH, Crowe JE*. Potent neutralization of Rift Valley fever virus by human monoclonal antibodies through fusion inhibition. Proc Natl Acad Sci USA. 2021; 118:e2025642118.
9. Alsoussi WB#, Turner JS#, Case JB#, Zhao H#, Schmitz AJ#, Zhou JQ#, Chen RE, Lei T, Rizk AA, McIntire KM, Winkler ES, Fox JM, Kafai NM, Thackray LB, Hassan AO, Amanat F, Krammer F, Watson CT, Kleinstein SH, Fremont DH, Diamond MS, Ellebedy AH*. A Potently Neutralizing Antibody Protects Mice against SARS-CoV-2 Infection. J Immunol. 2020;ji2000583.
10. Zhao H, Guo XK, Bi Y, Zhu Y, Feng WH*. PKCδ is required for porcine reproductive and respiratory syndrome virus replication. Virology. 2014;468-470:96-103.
11. Zhao H, Wang Y, Ma Z, Wang Y, Feng WH*. Recombinant Kluyveromyces lactis expressing highly pathogenic porcine reproductive and respiratory syndrome virus GP5 elicits mucosal and cell-mediated immune responses in mice. J Vet Sci. 2014;15:199-208.
