学习经历

2008.09-2013.06 北京大学/北京生命科学研究所，生物化学与分子生物学 （博士）

2003.09-2008.07 武汉大学医学院，临床医学（学士）；武汉大学生命科学学院，生物科学（学士，双学位）

主要工作经历与任职情况

2019.11-至今　　　武汉大学生命科学学院，病毒学国家重点实验室，PI

2016.08-2019.09　 美国南加州大学医学院分子微生物与免疫学系，博士后

2013.07-2016.08　 北京生命科学研究所/默沙东研发（中国），联合博士后

主要社会兼职

2020-今 中国研究型医院学会病毒肿瘤学专业委员会常任委员

2021-今 国际乙肝基金会（HBF）新兴学者科学和医学顾问委员会委员（E-SMAB）

获奖及荣誉

吴瑞奖学金-吴瑞基金会　2013

湖北省高层次人才项目　2020

主持课题项目

2021-2024年 国自然面上项目 PreS1与NTCP相互作用在HBV脱包膜过程中的功能与机制研究 主持

2023-2026年 国自然面上项目 ACE2在类MERS冠状病毒中的受体功能与宿主范围决定机制 主持

2024-2026年 国自然优秀青年科学基金  病毒受体与病毒入侵机制 主持

实验室研究生获奖

国家奖学金  3人次

武汉大学“研究生学术创新奖”特等奖  1人次

武汉大学雷军卓越奖学金  1人次

武汉大学十大学术之星 1人次

主要研究领域及兴趣

　　主要从事重要人类疾病相关病毒的受体与病毒入侵机制相关研究，目前重点关注人类与蝙蝠冠状病毒。致力于寻找、鉴定、设计与优化病毒受体, 揭示病毒受体识别与早期入侵过程的关系，阐明病毒宿主范围决定与跨物种传播的分子机制，建立新型病毒感染模型并开发新型病毒入侵抑制剂。

We are interested in the receptors and entry mechanisms of pathogenic viruses, specifically human and bat coronaviruses (CoVs). We are committed to the identification, design, and optimization of viral receptors. Additionally, we aim to uncover the mechanisms governing early entry events mediated by receptors, elucidate the factors influencing host range determination and cross-species transmission, and develop novel viral infection models for the creation of viral entry inhibitors.

发表的论文（#并列第一作者，*通讯作者）

代表性论文（Selected publications）：

成立实验室后(as PI)：

1. Chengbao Ma^#, Chen Liu^#, Qing Xiong^#, Mengxue Gu, Lulu Shi, Chunli Wang, Junyu Si, Fei Tong, Peng Liu, Meiling Huang, Huan Yan. Broad host tropism of ACE2-using MERS-related coronaviruses and determinants restricting viral recognition. Cell Discovery. 2023 Jun 15;9(1):57.

2. Huan Yan*, Chunli Wang, Key Factors for “Fishing” NTCP as a Functional Receptor for HBV and HDV. Viruses. 2023; 15(2), 512. （综述：HBV受体发现十年后总结当年受体发现的关键细节）

3. Qing Xiong^#, Lei Cao^#, Chengbao Ma^#, M. Alejandra Tortorici^#, Chen Liu, Junyu Si, Peng Liu, Mengxue Gu1, Alexandra C. Walls, Chunli Wang, Lulu Shi, Fei Tong, Meiling Huang, Jing Li, Chufeng Zhao, Chao Shen, Yu Chen, Huabin Zhao, Ke Lan, Davide Corti, David Veesler*, Xiangxi Wang^*, Huan Yan^*. Close relatives of MERS-CoV in bats use ACE2 as their functional receptors. Nature. 2022 Dec;612(7941):748-757.  （类MERS的冠状病毒受体鉴定）

4. Huan Yan^#, Hengwu Jiao^#, Qianyun Liu, Zhen Zhang, Qing Xiong, Bing-Jun Wang, Xin Wang, Ming Guo, Lin-Fa Wang, Ke Lan^*, Yu Chen^* & Huabin Zhao^*. ACE2 receptor usage reveals variation in susceptibility to SARS-CoV and SARS-CoV-2 infection among bat species. Nature Ecol Evol. 2021 May;5(5):600-608.

5. Qianyun Liu^#, Qing Xiong^#, Fanghua Mei^#, Chengbao Ma, Zhen Zhang, Bing Hu, Junqiang Xu, Yongzhong Jiang, Faxian Zhan, Suhua Zhou, Li Tao, Xianying Chen, Ming Guo, Xin Wang, Yaohui Fang, Shu Shen, Yingle Liu, Fang Liu, Li Zhou, Ke Xu, Changwen Ke, Fei Deng, Kun Cai*, Huan Yan^*, Yu Chen^*, Ke Lan^*. Antibody neutralization to SARS-CoV-2 and variants after one year in Wuhan, China. The Innovation. 2022 Jan 25;3(1):100181.

6. Chengbao Ma^#, Xianying Chen^#, Fanghua Mei^#, Qing Xiong, Qianyun Liu, Lianghui Dong, Chen Liu, Wenjing Zou, Faxian Zhan, Bing Hu, Yingle Liu, Fang Liu, Li Zhou, Junqiang Xu, Yongzhong Jiang, Ke Xu, Kun Cai^*, Yu Chen^*, Huan Yan^*，Ke Lan^*. Drastic decline in sera neutralization against SARS-CoV-2 Omicron variant in Wuhan COVID-19 convalescents. Emerg Microbes Infect. 2022 Dec;11(1):567-572.

成立实验室前(as student)：

Huan Yan^# , Guocai Zhong^# , Guangwei Xu, Wenhui He, Zhiyi Jing, Zhenchao Gao, Yi Huang, Yonghe Qi, Bo Peng, Haimin Wang, Liran Fu, Mei Song, Pan Chen, Wenqing Gao, Bijie Ren, Yinyan Sun, Tao Cai, Xiaofeng Feng, Jianhua Sui, Wenhui Li^*. Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus. eLife.  2012; 1: e00049. (Identification of HBV receptor NTCP,  which is a well recognized mile stone of the field. 相关研究发现获2020年乙肝研究最高奖Baruch Blumberg奖以及2022年未来科学大奖)

Huan Yan, Suan-Sin Foo, Weiqiang Chen, Ji-Seung Yoo, Woo-Jin Shin, Christine Wu, Jae U. Jung^*. Efficient inhibition of Human Papillomavirus infection by L2 minor capsid-derived lipopeptide. mBio.  2019 Aug 6;10(4):e01834-19. (Identification of putative HPV receptor binding peptide)

Huan Yan^#, Bo Peng^#, Yang Liu, Guangwei Xu, Wenhui He, Bijie Ren, Zhiyi Jing, Jianhua Sui, Wenhui Li^*. Viral Entry of Hepatitis B and D Viruses and Bile Salts Transportation Share Common Molecular Determinants on Sodium Taurocholate Cotransporting Polypeptide. J Virol. 2014 Mar;88(6):3273-84.

Huan Yan^#, Bo Peng^#, Wenhui He, Guocai Zhong, Yonghe Qi, Bijie Ren, Zhenchao Gao, Zhiyi Jing, Mei Song, Guangwei Xu, Jianhua Sui, Wenhui Li^*.Molecular determinants of hepatitis B and d virus entry restriction in mouse sodium taurocholate cotransporting polypeptide. J Virol., 2013 Jul;87(14):7977-91.

Yang Liu^#, Lei Zhang^#, Huan Yan^#, Zhiqiang Wang, Guoliang Sun, Xiao Song, Zhongmin Zhou, Bo Peng, Liwei Yan, Qingcui Wu, Wenhui Li^*, and Xiangbing Qi^*. Design of Dimeric Bile Acid Derivatives as Potent and Selective Human NTCP Inhibitors. J. Med. Chem., 2021 May 13;64(9):5973-6007.(Specific HBV inhibitors targeting NTCP）

Shixian Lin^#, Huan Yan^#, Lin Li, Maiyun Yang, Bo Peng, She Chen, Wenhui Li^*, Peng R Chen^*. Site-specific Engineering of Chemical Functionalities on the Surface of Live Hepatitis D Virus. Angew. Chem. Int. Ed., 2013 Dec;52(52), 13970-4.

综述：
1. Huan Yan, Wenhui Li*. Sodium taurocholate cotransporting polypeptide acts as a receptor for hepatitis B and D virus. Dig Dis. 2015 May; 33(3):388-96.

2. Huan Yan, Yang Liu, Jianhua Sui, Wenhui Li*. NTCP opens the door for hepatitis B virus infection. Antiviral Res. 2015 Sep;121:24-30.

招生招聘

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