2001.9－2005.6 中国地质大学外国语学院 英语专业 学士

2003.2－2005.6 武汉大学生命科学学院 生物科学专业 学士

2005.9－2010.6 武汉大学生命科学学院 细胞生物学 博士

工作经历

2010.7－2013.2　UT MD Anderson Cancer Center 博士后

2013.3－现在　　武汉大学生命科学学院、医学研究院
　　　　　　　　 教育部免疫代谢前沿科学中心，教授

主要社会兼职

中国细胞生物学会青年委员会委员

中国免疫学会青年委员会委员

中国细胞生物学学会免疫细胞学分会委员

Journal of Cell Biology 编委

Virologica Sinica编委

Cell Insight副主编

Frontier in Microbiology副主编

Nat Immunol, Advanced Science, J Clin Invest, Journal of Hepatology,  Nat Commun, PNAS, Cell Reports等杂志应邀审稿人

主持课题项目

1. 国家自然科学基金面上项目2项

2. 自然科学基金委优秀青年科学基金

3. 国家重大基础研究计划子项目（973）

4. 主持和参与重点研发计划2项

5. 教育部优秀博士论文获得者基金(201427): 2014.01-2017.12

6. 国家自然科学基金委重点项目

研究兴趣

本实验室主要从事抗病毒天然免疫信号转导、炎性细胞因子介导的炎症反应与肿瘤发生的分子机理的研究。我们主要以表达克隆、酵母双杂交以及蛋白质组学等多种手段，筛选参与调控抗病毒天然免疫以及炎症反应过程的蛋白，并通过基因敲除、转基因小鼠以及动物疾病模型研究这些蛋白在调控病毒感染、自身免疫性疾病以及肿瘤发生等过程中的功能与机制。

发表的论文（#并列第一作者；*通讯作者）

1. Xiong TC#, Wei MC#, Li FX#, Shi M, Gan H, Tang Z, Dong HP, Liuyu T, Gao P, Zhong B*, Zhang ZD*, Lin D*. The E3 ubiquitin ligase ARIH1 promotes antiviral immunity and autoimmunity by inducing mono-ISGylation and oligomerization of cGAS. Nat Commun, 2022, Accepted.
2. Zhong B* and Shu HB*. MITA/STING-mediated antiviral immunity and autoimmunity: the evolution, mechanism and intervention. Current Opinion in Immunology, 2022, In press.
3. An R, Wang P, Guo H, Liuyu T, Zhong B*, Zhang ZD*. USP2 promotes experimental colitis and bacterial infections by inhibiting the proliferation of myeloid cells and remodeling the extracellular matrix network. Cell Insight, 2022, 1(4): 100047. doi: 10.1016/j.cellin.2022.100047.
4. Zhang ZD, Li HX, Gan H, Tang Z, Guo YY, Yao SQ, Liuyu T, Zhong B*, Lin D*.  RNF115 inhibits the post-ER trafficking of TLRs and TLRs-mediated immune responses by catalyzing K11-linked ubiquitination of RAB1A and RAB13. Adv Sci, 2022, 9(16): 2105391. doi: 10.1002/advs.202105391.
5. Yang W#, Dong HP#, Wang P#, Xu ZG, Xian J, Chen J, Wu H, Lou Y, Lin D*, Zhong B*. IL-36g and IL-36Ra reciprocally regulate colon tumorigenesis by modulating the cell-matrix adhesion network and Wnt signaling. Adv Sci, 2022, 9(10): 2103035. doi: 10.1002/advs.202103035.
6. Zhang ZD, Zhong B*. Regulation and function of the cGAS-MITA/STING axis in health and disease. Cell Insight, 2022, 1(1): 100001. doi: 10.1016/j.cellin.2021.100001.
7. Wang P#, Yang W#, Guo H, Dong HP, Guo YY, Gan H, Wang Z, Cheng Y, Deng Y, Xie S, Yang X, Lin D*, Zhong B*. IL-36g and IL-36Ra reciprocally regulate NSCLC progression by modulating GSH homeostasis and oxidative stress-induced cell death. Adv Sci, 2021, 8(19): 2101501. doi: 10.1002/advs.202101501.
8. Zhang M#, Yang W#, Wang P, Deng Y, Dong YT, Liu FF, Huang R, Zhang P, Duan YQ, Liu XD, Lin D*, Chu Q*, Zhong B*. CCL7 recruits cDC1 to promote antitumor immunity and facilitate checkpoint immunotherapy to non-small cell lung cancer. Nat Commun, 2020, 11: 6119. Nov 30, doi: 10.1038/s41467-020-19973-6.
9. Zhang ZD#, Xiong TC#, Yao SQ, Wei MC, Chen M, Lin D, Zhong B*. RNF115 plays dual roles in innate antiviral responses by catalyzing distinct ubiquitination of MAVS and MITA. Nat Commun, 2020, 11: 5536. Nov 2, doi: 10.1038/s41467-020-19318-3.
10. Wang XM, Yang C, Zhao Y, Xu Z, Yang W, Wang P, Lin D, Xiong B, Fang J, Dong C, Zhong B*. The deubiquitinase USP25 supports colonic inflammation and bacterial infection and promotes colorectal cancer. Nat Cancer, 2020, 1: 811-825. July 6, doi: 10.1038/s43018-020-0089-4.
11. Zhang Q, Tang Z, An R, Ye L, Zhong B*. USP29 maintains the stability of cGAS and promotes cellular antiviral responses and autoimmunity. Cell Res, 2020, 30, 914-927. May 26, doi: 10.1038/s41422-020-0341-6.
12. Cai Z, Zhang MX, Tang Z, Zhang Q, Ye J, Xiong TC, Zhang ZD, Zhong B*. USP22 promotes IRF3 nuclear translocation and antiviral responses by deubiquitinating the importin protein KPNA2. J Exp. Med., 2020, 217, 5: e20191174.
13. Li SZ*, Shu QP, Song Y, Zhang HH, Liu Y, Jin BX, Liuyu TZ, Li C, Huang XC, Du RL, Song W*, Zhong B*, Zhang XD*. Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response. Nat Commun, 2019, 10(1): 3233.
14. Ye L#, Zhang Q#, Liuyu T, Xu Z, Zhang MX, Luo MH, Zeng WB, Zhu Q, Lin D*, Zhong B*. USP49 negatively regulates cellular antiviral responses via deconjugating K63-linked ubiquitination of MITA. Plos Pathog, 2019, 15(4): e1007680.
15. Zhang MX, Cai Z, Zhang M, Wang XM, Wang Y, Zhao F, Zhou J, Luo MH, Zhu Q, Xu Z, Zeng WB*, Zhong B*, Lin D*. USP20 promotes cellular antiviral responses via deconjugating K48-linked ubiquitination of MITA. J Immunol, 2019, 202(8):2397-2406.
16. Liuyu T, Yu K, Ye L, Zhang Z, Zhang M, Ren Y, Cai Z, Zhu Q, Lin D, Zhong B*, Induction of OTUD4 by viral infection promotes antiviral responses through deubiquitinating and stabilizing MAVS. Cell Res, 2019, 29(1):67-79.
17. Zhao Y, Wang XM, Wang Q, Deng Y, Li K, Zhang M, Zhang Q, Zhou J, Wang HY, Bai P, Ren Y, Zhang N, Li W, Cheng Y, Xiao W, Du HN, Cheng X, Yin L, Fu X, Lin D, Zhou Q, Zhong B*, USP2a supports metastasis by tuning TGF-b signaling. Cell Rep, 2018, 22(9):2442-2454.
18. Li K, Zhong B*, Regulation of cellular antiviral signaling by modifications of ubiquitin and ubiquitin-like molecules. Immune Network. 2018, 18(1):e4. (Invited review)
19. Lu B#, Ren Y#, Sun X#, Han C, Wang H, Chen Y, Peng Q, Cheng Y, Cheng X, Zhu Q, Li W, Li HL,  Du HN, Zhong B*, Huang Z*. Induction of INKIT by viral infection negatively regulates antiviral responses through inhibiting phosphorylation of p65 and IRF3. Cell Host Microbe, 2017, 22(1):86-98.e4.(Cover story)
20. Sun H#, Zhang Q#, Jing YY, Zhang M, Wang HY, Cai Z, Liuyu T, Zhang ZD, Xiong TC, Wu Y, Zhu QY, Yao J, Shu HB, Lin D, Zhong B*. USP13 negatively regulates antiviral responses by deubiquitinating STING. Nat Commun. 2017, May 23; 8:15534. 10.1038/NCOMMS15534.
21. Zhang M#, Zhang MX#, Zhang Q, Zhu GF, Yuan L, Zhang DE, Zhu QY, Yao J, Shu HB, Zhong B*. USP18 recruits USP20 to promote innate antiviral response through deubiquitinating STING/MITA. Cell Res. 2016, 26(12): 1302-1319.
22. Ren Y, Zhao Y, Lin D, Xu X, Zhu Q, Yao J, Shu HB, Zhong B*. The type I interferon-IRF7 axis mediates transcriptional expression of Usp25 gene. J Biol Chem. 2016, 291(25): 13206-13215.
23. Lin D, Zhang M, Zhang MX, Ren YJ, Jin J, Zhao Q, Pan Z, Wu M, Shu HB, Dong C, Zhong B*. Induction of USP25 by viral infection promotes innate antiviral responses by mediating the stabilization of TRAF3 and TRAF6. Proc Natl Acad Sci U S A. 2015 112(36):11324-329.
24. Lin D, Zhong B*. Regulation of cellular innate antiviral signaling by ubiquitin modification. Acta Biochim Biophys Sin. 2015 47(3):149-155. (Invited Review)