2002－2008  中科院生物化学与细胞生物学研究所，博士

1998－2002  吉林大学生物化学系，学士

主要工作经历与任职情况

2016－至今  武汉大学生命科学学院，教授，博士生导师

2013－2015  加州大学欧文分校医学院，研究助理

2008－2013  加州大学欧文分校医学院，博士后

主要研究领域及兴趣

　　目前，真菌感染随着广谱抗生素的滥用和介入性治疗的广泛应用呈现逐年上升的趋势。其中，白念珠菌是人体内一种最常见的机会型致病真菌，60-70%侵入性真菌感染是由白念珠菌引起的。本实验室将以探究白念珠菌致病机制为基础来建立致病真菌与宿主互作关系的实验平台（整合遗传学、生物化学、系统生物学和实验动物感染模型），以期找到新的药物靶点来有效对抗真菌的系统性感染。

　　主要研究工作包括：1）真菌对宿主体内环境因子的感受器的鉴定和分子机制研究；2）病原真菌从共生菌到致病菌的转换机理；3)真菌的效应因子调控宿主免疫系统的机制；4）真菌耐药机制的研究以及抗真菌药物的筛选。

主持课题项目

国家高层次人才青年项目

国家自然科学基金委

武汉大学自主科研

中南医院转化医学项目

代表性论文（*corresponding author, #co-first author)

(1) Gang Luo^#; Jingkai Zhang^#; Tianxu Wang^#; Hao Cui; Yukun Bai; Jianchen Luo; Jinqiu Zhang; Mao Zhang; Linyan Di; Yuncong Yuan; Kang Xiong; Xiangtai Yu; Yaling Zhang; Chao Shen; Cheng Zhu; Yong Wang; Chang Su; Yang Lu*; A human commensal-pathogenic fungus suppresses host immunity via targeting TBK1, Cell Host & Microbe, 2024, 23: S1931-3128 (24) 00262-2
Highlighted at Cell Host & Microbe, Stealth strategies of Candida albicans to evade host immunity. 32(9) 1459-1461
(2) Mao Zhang; Cheng Zhu; Yuanyuan Duan; Tong-Bao Liu; Haoping Liu; Chang Su*; Yang Lu*; The intrinsically disordered region from PP2C phosphatases functions as a conserved CO2 sensor, Nature Cell Biology, 2022, 24(7): 1029-1037
Highlighted at Nature Reviews Molecular Cell Biology, CO2 sensing through PP2C condensates. 23(4) 519  
Highlighted at Nature Cell Biology, Intrinsically disordered CO2 sensors. 24 (7) 1013-1014  
Highlighted at Nature Chemical Biology, Sensing the air. 18 (8) 793  
Recommended by Faculty Option.
(3) Dandan Yang; Mao Zhang; Chang Su; Bin Dong; Yang Lu*; Candida albicans exploits N-acetylglucosamine as a gut signal to establish the balance between commensalism and pathogenesis, Nature Communications, 2023, 14(1)

Highlighted at Trends in Microbiology, N-acetylglucosamine: a behavioral switch in Candida albicans. 31(11) 1087-1089
(4) Mao Zhang; Youzhi Zhao; Hao Cui; Wenqiang Huang; Kang Xiong; Shan Yang; Yuanyuan Duan; Yong He; Lianjuan Yang; Chang Su; Yang Lu*; Carbon dioxide potentiates echinocandin efficacy during invasive candidiasis therapy via dephosphorylation of Hsp90 by Ptc2 in condensates, PNAS, 2025, 122(6)
(5) Xun Sun; Jing Yu; Cheng Zhu; Xinreng Mo; Qiangqiang Sun; Dandan Yang; Chang Su*; Yang Lu*; Recognition of galactose by a scaffold protein recruits a transcriptional activator for the GAL regulon induction in Candida albicans, eLife, 2023, 12(e84155)
(6) Yaling Zhang#; Lianjuan Yang; Youzhi Zhao; Kang Xiong; Hao Cui; Tianxu Wang; Xiaoping Liu; Chang Su; Yang Lu*. Adaptive evolution of Candida albicans through modulating TOR signaling, mBio, 2025, 16(4): e0394724
(7) Hao Cui; Dandan Yang; Shengwei Gong; Yaling Zhang; Bin Dong; Chang Su; Lianjuan Yang*; Yang Lu*; The transcription factor Ofi1 is critical for white‐opaque switching in natural MTLa/α isolates of Candida albicans, Molecular Microbiology, 2024, 121(2): 275-290
(8) Yaling Zhang; Shengwei Gong; Kang Xiong; Xiangtai Yu; Xinreng Mo; Chang Su; Yang Lu*; An alteration in the expression of cell wall structural proteins increases cell surface exposure of adhesins to promote virulence in Candida glabrata, mSphere, 2024 Dec 19: e0091024
(9) Xinreng Mo; Xiangtai Yu; Hao Cui; Kang Xiong; Shan Yang; Chang Su*; Yang Lu*; In vivo RNA sequencing reveals a crucial role of Fus3-Kss1 MAPK pathway in Candida glabrata pathogenicity, mSphere, 2024 Oct 30: e0071524
(10) Qiangqiang Sun; Bin Dong; Dandan Yang; Jing Yu; Tianhao Ren; Tianxu Wang; Lianjuan Yang; Yang Lu*; Chang Su*; Zcf24, a zinc‐finger transcription factor, is required for lactate catabolism and inhibits commensalism in Candida albicans, Molecular Microbiology, 2023, 119(1): 112-125
(11) Kang Xiong^#, Chang Su^#, Qiangqiang Sun and Yang Lu*. (2021)Efg1 and Cas5 Orchestrate Cell Wall Damage Response to Caspofungin in Candida albicans. Antimicrobial Agents and Chemotherapy 65 (2) e01584-20
(12) Qiangqiang Sun, Kang Xiong, Yuncong Yuan, Jing Yu, Lianjuan Yang, Chao Shen, Chang Su*, and Yang Lu*. (2020) Inhibiting fungal echinocandin resistance by small-molecular disruption of geranylgeranyltransferase type I activity. Antimicrobial Agents and Chemotherapy 64 (2) 02406-19
(13) Yang Lu*^#; Chang Su^#; Shatarupa Ray; Yuncong Yuan; Haoping Liu*. (2019) CO2 signaling through the Ptc2-Ssn3 axis governs sustained hyphal development of Candida albicans by reducing Ume6 phosphorylation and degradation. mBio 10 (1) 02320-18
(14) Chang Su#; Jing Yu#; Qiangqiang Sun; Qian Liu; Yang Lu*. (2018) Hyphal induction under the condition without inoculation in Candida albicans is triggered by Brg1-mediated removal of NRG1 inhibition. Molecular Microbiology 108(4): 410-423

招生招聘

热忱欢迎本科生、硕士生、博士生、博士后加入本实验室。

每年拟接收1-2名本科生，1名硕士生和2名博士生，博士后可以随时联系。