学习经历

1983.9-1987.6   兰州大学，生物学系动物学专业，学士

1987.9-1990.6   中国医学科学院/中国协和医科大学，基础医学所细胞生物学专业，硕士

1992.9-1995.6   美国Emory大学，细胞与发育生物学专业，博士

主要工作经历与任职情况

1995.7-1997.7　　美国Tularik公司David Goeddel实验室，博士后

1997.8-1998.7　　美国Magainin制药公司，资深科学家

1998.8-2003.6　　美国犹太医学研究中心、科罗拉多大学医学院，助理教授

2003.7-2005.7　　美国犹太医学研究中心、科罗拉多大学医学院，副教授

1999.9-2005.7　　美国科罗拉多大学癌症中心，研究员

2005.9-现在　　　武汉大学生命科学学院，教授

2005.9-2013.12　 武汉大学生命科学学院，院长

2013.8-2022.1　　武汉大学，副校长

2014.5-现在　　　武汉大学医学研究院，院长

2018.12-现在　　 免疫与代谢前沿科学中心，首席科学家

2022.5-现在　　　武汉生物技术研究院，院长

2022.7-现在　　　武汉大学泰康生命医学中心，PI

主要社会兼职

第十三届全国政协常委委员（2018-2022）

第十二届全国政协委员（2013-2017）

陈嘉庚生命科学奖第七、八、九届评奖委员会委员（2016-现在）

湖北省党外知识分子联谊会常务副会长（2015-2020）

国务院学位委员会第七、八届学科评议组成员（2014-现在）

教育部高等学校生物技术学科教学指导委员会副主任委员（2013-2017）

教育部科技委生物与医学部委员（2009-2013）

国家自然基金委/中科院“12.5生物学学科发展战略”研究组成员、秘书组组长（2009-2010）

国家自然基金委生命科学部第四届专家咨询委员会委员（2008-2011）

谈家桢生命科学奖评审委员会委员（2013-现在）

中国细胞生物学学会副理事长、免疫细胞生物学分会会长（2007-2014）

湖北省细胞生物学学会理事长（2007-2013）

湖北省人民政府参事（2013-2022）

Cell Insight主编（2021-现在）

Pathogens编委（2021-现在）

Current Research in Immunology编委（2020-现在）

Current Opinion in Immunology编委（2018-现在）

Cytokine & Growth Factor Reviews 编委（2018-现在）

Cell Discovery编委（2015-现在）

Cell Research编委（2010-现在）

Cell and Molecular Immunology 编委（2009-现在）

Protein & Cell 编委（2009-现在）

Journal of Molecular Cell Biology副主编（2009-2016）

中国科学C辑－生命科学编委（2008-2013）

Journal of Biological Chemistry编委（2007-2012）

主要科研奖励和个人荣誉

中国科学院院士（2011）

发展中国家科学院院士（2012）

Nature杰出导师奖（2015）

国家自然科学二等奖两项（第一完成人，2010，2015）

教育部自然科学一等奖两项（第一完成人，2006，2014）

十佳全国优秀科技工作者提名奖（2014）

全国优秀科技工作者（2014）

中国侨界杰出人物提名奖（2013）

“万人计划”第一批科技创新领军人才（2013）

国务院政府特殊津贴（2011）

国家杰出青年基金获得者（1999）

新世纪百千万人才工程国家级人选（2007）

全国优秀博士学位论文指导教师（2013, 2014）

中国细胞生物学学会杰出成就奖（2009）

谈家祯生命科学创新奖（2009）

主持课题项目

作为首席科学家承担了3项国家重大科学研究计划或重点专项项目，作为学术带头人主持了国家基金委“病原体与宿主”基础科学中心、“抗病毒天然免疫”创新研究群体项目（获得三期资助）和6项重点项目。

发表的论文（#并列第一作者，*通讯作者）（45 out of 187）：

通讯作者论文单篇最高被SCI引用1449次，连续八年入选“中国高被引学者”榜单。

1. Hsu H, Shu HB, Pan MG, Goeddel DV (1996). TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor-1 signal transduction pathways. Cell 84:299-308.

2. Shu HB, Takeuchi M, Goeddel DV (1996). The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex. PNAS 93:13973-13978.

3. Shu HB, Halpins DR, Goeddel DV (1997). Casper is a FADD and Caspase-related Inducer of Apoptosis. Immunity 6:751-763.

4. Yeh WC, Pompa JL, McCurrach ME, Shu HB, Elia AJ, Shahinian A, Ng M, Wajegam A, Mithchell K, El-Deiry WS, Lowe SW, Goeddel DV and M,ak TW (1998). FADD: essential for embryonic development and signaling from some, but not all, inducers of apoptosis. Science 279:1954-1958.

5. Shu HB*, Hu WH, Johnson H (1999). TALL-1 is a novel member of the TNF family that is downregulated by mitogens. J Leukocyte Biol 65:680-683.

6. Shu HB*, Johnson H (2000). BCMA is a receptor for the TNF family member TALL-1. PNAS 97:9156-9161.

7. Liu Y, Xu L, Opalka N, Kappler J, Shu HB, Zhang G (2002). Crystal structure of sTALL-1 reveals a virus-like assembly of TNF family ligands. Cell 108: 383-394.

8. Liu Y, Hong X, Kappler J, Jiang L, Zhang R, Xu L Pan CH, Martin WE, Murphy RC, Shu HB, Dai S, and Zhang G (2003). Ligand-receptor binding revealed by the TNF family member TALL-1. Nature 423:49-56.

9. Xu LG, Wang YY, Han KJ, Li LY, Zhai Z, Shu HB* (2005). VISA is an adapter protein required for virus-triggered signaling. Molecular Cell 19:727-740.

10. Huang J, Liu T, Chen D, Zhai Z, Shu HB* (2005). SIKE is an IKK-relative kinases-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways. EMBO J 24:4018-4028.

11. Diao F, Li S, Tian Y, Zhang M, Xu LG, Zhang Y, Wang RP, Chen D, Zhai Z, Zhong B, Tien P, Shu HB* (2007). Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase. PNAS 104:11706-11711.

12. Zhang BC, Huang J, Li HL, Liu T, Wang YY, Waterman P, Mao AP, Xu LG, Zhai Z, Liu D, Marrack P, Shu HB* (2008). GIDE is a mitochondrial E3 ubiquitin ligase that induces apoptosis and slows growth. Cell Research 18:900-910.

13. Zhong B, Yang Y, Li S, Wang YY, Li Y, Diao F, Lei C, He X, Zhang L, Tien P, Shu HB* (2008). The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation. Immunity 29:538-550.

14. Zhong B, Zhang L, Lei Z, Li Y, Mao AP, Yang Y, Wang YY, Zhang XL, Shu HB* (2009). The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA. Immunity 30:397-407.

15. Li Y, Li C, Xue P, Zhong B, Mao AP, Ran Y, Chen H, Wang YY, Yang F, Shu HB* (2009). ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response. PNAS 106:7945-7950.

16. Wang YY, Liu LJ, Zhong B, Liu TT, Li Y, Yang Y, Ran Yong, Li S, Tien P, Shu HB* (2010). WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-B activation. PNAS 107:815-820.

17. Chen R, Zhang L, Zhong B, Tan B, Liu Y, Shu HB* (2010). The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling. Cell Research 20:802-811.

18. Lei CQ, Zhong B, Zhang Y, Zhang J, Shu HB* (2010). GSK3b regulates virus-triggered IRF3 activation and cellular antiviral response by promoting TBK1 activation. Immunity 33:878-889.

19. Li Q, Yan J, Mao AP, Li C, Ran Y, Shu HB*, Wang YY (2011). Tripartite motif 8 (TRIM8) modulates  TNFα- and IL-1β-triggered NF-κB activation by targeting TAK1 for K63-linked  polyubiquitination. PNAS 108:19341-19346.

20. Li Y, Chen R, Zhou Q, Xu Z, Li C, Wang S, Mao A, Zhang X, He W, Shu HB* (2012). LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection. PNAS 109:11770-11775.

21. Wang YY, Ran Y, Shu HB* (2012).Linear ubiquitination of NEMO brakes the antiviral response. Cell Host Microbe 12:129-131.

22. Chen R, Li M, Zhang Y, Zhou Q, Shu HB* (2012). The E3 ubiquitin ligase MARCH8 negatively regulates IL-1β-induced NF-κB activation by targeting the IL1RAP coreceptor for ubiquitination and degradation. PNAS 109:14128-14133.

23. Hu MM, Yang Q, Zhang J, Liu SM, Zhang Y, Lin H, Huang ZF, Wang YY, Zhang XD, Zhong B, Shu HB* (2014). TRIM38 inhibits TNFα- and IL-1β-triggered NF-κB activation by mediating lysosome-dependent degradation of TAB2/3. PNAS 114:1509-1514.

24. Zhou Q, Lin H, Wang SY, Wang S, Ran Y, Liu Y, Ye W, Xiong XZ, Zhong B, Shu HB*, Wang YY (2014). The ER-associated protein ZDHHC1 is a positive regulator of DNA virus-triggered, MITA/STING-dependent innate immune signaling. Cell Host Microbe 16:450-461.

25. Shu HB*, Wang YY* (2014). Adding to the STING. Immunity 41:871-873.

26. Luo WW, Li S, Li C , Lian H, Yang Q, Zhong B, Shu HB*(2016).iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING. Nature Immunology 17: 1057-1066.

27. Hu MM, Yang Q, Xie XQ, Liao CY, Lin H, Liu TT, Yin L, Shu HB* (2016). Sumoylation Promotes the Stability of the DNA Sensor cGAS and the Adaptor STING to Regulate the Kinetics of Response to DNA Virus. Immunity 45: 555-569

28. Fu YZ, Su S, Gao YQ, Wang PP, Huang ZF, Hu MM, Luo WW, Li S, Luo MH, Wang YY, Shu HB* (2017). Human Cytomegalovirus Tegument Protein UL82 Inhibits STING-Mediated Signaling to Evade Antiviral Immunity. Cell Host Microbe. 21:231-243.

29. Hu MM, Liao CY, Yang Q, Xie XQ, Shu HB* (2017). Innate immunity to RNA virus is regulated by temporal and reversible sumoylation of RIG-I and MDA5. J Exp Med 214:973-989.

30. Wei J, Guo W, Lian H, Yang Q, Lin H, Li S*, Shu HB* (2017). SNX8 mediates IFNγ-triggered noncanonical signaling pathway and host defense against Listeria monocytogenes. PNAS 114:13000-13005.

31. Hu MM, Shu HB* (2018). Cytoplasmic Mechanisms of Recognition and Defense of Microbial Nucleic Acids. Annu Rev Cell Dev Biol 34:357-379

32. Lian H, Wei J, Zang R, Ye W, Yang Q, Zhang XN, Chen YD, Fu YZ, Hu MM, Lei CQ, Luo WW, Li S*, Shu HB* (2018). ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response. Nature Communications 9: 3349. doi: 10.1038/s41467-018-05559-w

33. Zhang HX, Xu ZS, Lin H, Li M, Xia T, Cui KS, Wang SY, Li YJ, Shu HB*, Wang YY* (2018). TRIM27 mediates STAT3 activation at retromer-positive structures to promote colitis and colitis-associated carcinogenesis. Nature Communications 9: 3441. doi: 10.1038/s41467-018-05796-z

34. Lian H, Zang R, Wei J, Ye W, Hu MM, Chen YD, Zhang XN, Guo Y, Lei CQ, Yang Q, Luo WW, Li S*, Shu HB* (2018). The Zinc-Finger Protein ZCCHC3 Binds RNA and Facilitates Viral RNA Sensing and Activation of the RIG-I-like Receptors. Immunity 49: 438-448

35. Lin H, Gao D, Hu MM, Zhang M, Wu XX, Feng L, Xu WH, Yang Q, Zhong X, Wei J, Xu ZS, Zhang HX, Song ZM, Zhou Q, Ye W, Liu Y, Li S, Shu HB* (2018). MARCH3 attenuates IL-1 beta-triggered inflammation by mediating K48-linked polyubiquitination and degradation of IL-1RI. PNAS 115: 12483-12488

36. Hu MM*, He WR, Gao P, Yang Q, He K, Cao LB, Li S, Feng YQ, Shu HB* (2019). Virus-induced accumulation of intracellular bile acids activates the TGR5-beta-arrestin-SRC axis to enable innate antiviral immunity. Cell Research 29(3):193-205

37. Wu X, Lei CQ, Xia T, Zhong X, Yang Q, Shu HB* (2019). Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination. Nature Communications 10:4115

38. Xia T, Yi XM, Wu X, Shang J, Shu HB* (2019). PTPN1/2-mediated dephosphorylation of MITA/STING promotes its 20S proteasomal degradation and attenuates innate antiviral response. PNAS 116:20063-20069

39. Hu MM, Shu HB* (2020). Innate Immune Response to Cytoplasmic DNA: Mechanisms and Diseases. Ann Rev Immunol 38:78-89

40. Zhong L, Hu MM, Bian LJ, Liu Y, Chen Q and Shu HB* (2020). Phosphorylation of cGAS by CDK1 impairs self-DNA sensing in mitosis. Cell Discovery 6:26

41. Song ZM, Lin H, Yi XM, Guo W, Hu MM, Shu HB* (2020). KAT5 acetylates cGAS to promote innate immune response to DNA virus. PNAS 117:21568-21575

42. Liu R, Zeng LW, Gong R, Yuan F, Shu HB, Li S* (2021). mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis. Nature Communications 12(1):4227

43. Feng L, Li C, Zeng LW, Gao D, Sun YH, Zhong L, Lin H, Shu HB*, Li S* (2022). MARCH3 negatively regulates IL-3-triggered inflammatory response by mediating K48-linked polyubiquitination and degradation of IL-3Rα. Signal Transduction and Targeted Therapy 7(1):21

44. Yi XM, Li M, Chen YD, Shu HB, Li S* (2022). Reciprocal regulation of IL-33 receptor-mediated inflammatory response and pulmonary fibrosis by TRAF6 and USP38. PNAS 119(10):e2116279119
45. Su S^#, Hua D^#, Li JP^#, Zhang XN, Bai L, Cao LB, Guo Y, Zhang M, Dong JZ, Liang XW, Lan K, Hu MM*, Shu HB* (2022). Modulation of innate immune response to viruses including SARS-CoV-2 by progesterone. Signal Transduction and Targeted Therapy 7(1):137

发表著作

舒红兵 主编，《抗病毒天然免疫》，科学出版社，北京，2009

舒红兵 主编，《中国学科发展战略·免疫学》，科学出版社，北京，2015