刘 勇教授、 国家杰出青年基金获得者、博士 Professor, Recipient of National Outstanding Young Scientist Award of NSFC , Ph.D.













         Rutgers University, PhD


         Peking University, Master's Degree


         Peking University, Bachelor's Degree

工作经历/Professional Experience

2015.09 - 至今: 武汉大学生命科学学院

         College of Life Sciences, Wuhan University


         Institute for Nutritional Sciences, Shanghai Institutes of
         Biological Sciences, Chinese Academy of Sciences


         AlleCure/Mankind Corp., CA, USA

1995.03-2000.10:美国加州大学Santa Barbara分校分子、细胞与发育生物学系

         Department of MCDB, University of California at Santa Barbara, CA, USA

社会兼职/Social Part-time Jobs

2012年 - 至今: J. Biol. Chem.杂志,编委

         Journal of Biological Chemistry, Editorial Board Member

奖励荣誉/Awards and Honors

2004年 中科院高层次人才项目

2009年 国家杰出青年科学基金

2009年 明治乳业生命科学优秀奖

2010年 上海市优秀学科带头人

2010年 国家自然科学基金委创新群体骨干

2011年 国务院政府特殊津贴

2011年 药明康德生命化学研究奖

2012年 国家重大科学研究973计划首席科学家

2012年 上海市领军人才

研究方向/Research Fields

1) 细胞应激与糖脂代谢紊乱的分子机制

  The molecular mechanisms linking cellular stress pathways and metabolic dysfunctions

2) 内质网应激与免疫炎性疾病的分子基础

  ER stress in the molecular pathogenesis of inflammatory diseases

研究概述/Research Description:


Our research aims to elucidate the molecular mechanisms that link overnutrition, endoplasmic reticulum (ER) stress and metabolic/inflammatory disorders. Employing animal models, we attempt to dissect the physiological actions of the IRE1α arm of the unfolded protein response (UPR) in nutrient-sensing, metabolic control and immune homeostasis. Our studies will provide new insights into the pathogenic mechanisms underlying obesity, type 2 diabetes, NASH and other aging-related chronic inflammatory diseases.

科研项目/Rresearch Project

2023.01-2027.12  国家自然科学基金重点项目,内质网应激IRE1α通路调控肝脏与脂肪间对话在代谢紊乱中的作用和机制研究,主持
2021.01-2025.12  国家自然科学基金创新研究群体项目,脂代谢的稳态调控与重编程,骨干

2019.09-2024.08  国家科技部重点研发计划,应激对组织器官代谢稳态和发育的调控作用与机制,主持

2019.01-2022.12  国家自然科学基金重大研究计划,内质网应激感应分子IRE1α的代谢性激活在代谢稳态中的调控作用与机制,主持

2017.01-2021.12  国家自然科学基金重大项目,介导脂代谢可塑性的重要细胞器及其调控机制,主持

代表性学术论文/Selected Publications

1) Chen Y, Wu Z, Huang S, Wang X, He SJ, Liu L, Hu Y, Chen L, Chen P, Liu S, He SQ, Shan B, Zheng L, Duan S, Song Z, Jiang L, Wang QA, Gan Z, Song BL, Liu J, Rui LY, Shan M, Liu Y*. (2022) Adipocyte IRE1α promotes PGC1α mRNA decay and restrains adaptive thermogenesis. Nat Metab. 4(9):1166-1184.
2) Li Y, Huang S, Wang J, Dai J, Cai J, Yan S, He S, Wang P, Jianmiao Liu J, Liu Y*. (2022) Phosphorylation at Ser724 of the ER stress sensor IRE1α governs its activation state and limits ER stress-induced hepatosteatosis.
J Biol Chem. 298(6):101997.
3) Cai J, Zhang X, Chen P, Li Y, Liu S, Liu Q, Zhang H, Wu Z, Song K, Liu J, Shan B*,
Liu Y*. (2022) The ER stress sensor inositol-requiring enzyme 1α in Kupffer cells promotes hepatic ischemia-reperfusion injury. J Biol Chem. 298(1):101532.
4) He S, Fu T, Yu Y, Liang Q, Li L, Liu J, Zhang X, Zhou Q, Guo Q, Xu D, Chen Y, Wang X, Chen Y, Liu J, Gan Z,
Liu Y*. (2021) IRE1α regulates skeletal muscle regeneration through Myostatin mRNA decay. J Clin Invest. 131(17):e143737.
5) Zhao P, Huang P, Xu T, Xiang X, Sun Y, Liu J, Yan C, Wang L, Gao J, Cui S, Wang X, Zhan L, Song H, Liu J, Song W*,
Liu Y*. (2021) Fat body Ire1 regulates lipid homeostasis through the Xbp1s-FoxO axis in Drosophila. iScience. 24(8):102819.
6) Liu L, Cai J, Wang H, Liang X, Zhou Q, Ding C, Zhu Y, Fu T, Guo Q, Xu Z, Xiao L, Liu J, Yin Y, Fang L, Xue B, Wang Y, Meng ZX, He A, Li JL,
Liu Y, Chen XW*, Gan Z*. (2019) Coupling of COPII vesicle trafficking to nutrient availability by the IRE1α-XBP1s axis. Proc Natl Acad Sci U S A. 116(24):11776-11785.
7) Huang S, Xing Y. and Liu Y*. (2019) Emerging roles for the ER stress sensor IRE1α in metabolic regulation and disease.
J Biol. Chem. 294(49) 18726–18741. (Review)
8) Yan C, Liu J, Gao J, Sun Y, Zhang L, Song H, Xue L, Zhan L, Gao G, Ke Z, Liu Y*, Liu J*. (2019) IRE1 promotes neurodegeneration through autophagy-dependent neuron death in the Drosophila model of Parkinson's disease. Cell Death Dis. 10(11):800.
Wu Y, Shan B, Dai J, Xia Z, Cai J, Chen T, Lv S, Feng Y, Zheng L, Wang Y, Liu J, Fang J, Xie D, Rui L, Liu J, Liu Y*. (2018) Dual Role for Inositol-requiring Enzyme 1α in Promoting the Development of Hepatocellular Carcinoma during Diet-induced Obesity. Hepatology 68:533-546.
10) Shan B, Wang X, Wu Y, Xu C, Xia Z, Dai J, Shao M, Zhao F, He S, Yang L, Zhang M, Nan F, Li J, Liu J, Liu J, Jia W, Qiu Y, Song B, Han JJ, Rui L, Duan SZ*, Liu Y*. (2017) The Metabolic ER Stress Sensor IRE1α Suppresses Alternative Activation of Macrophages to Impair Energy Expenditure in Obesity. Nat Immunol. 18:519-529.
(Highlighted in News and Views, Nature Immunol. 18:479-480, 2017; Preview, Mol Cell 66:731-733, 2017; Nat Rev Immunol. 17:277, 2017; Nat Rev Endocrinol. 13:315, 2017)11) Xiao Y, Xia T, Yu J, Deng Y, Liu H, Liu B, Chen S, Liu Y*, Guo F*. (2016) Knockout of inositol-requiring enzyme 1α in pro-opiomelanocortin neurons decreases fat mass via increasing energy expenditure. Open Biol. 6(8). pii: 160131.
12) Wu J, Yang L, Li S, Huang P, Liu Y*, Wang Y*, Tang H*. (2016) Metabolomics Insights into the Modulatory Effects of Long-Term Low Calorie Intake in Mice. J Proteome Res. 15:2299-308.
13) Qiu Y*, Shan B, Yang L,
Liu Y*. (2016) Adipose tissue macrophage in immune regulation of metabolism. Sci China Life Sci. 59:1232-1240. (Review)
14) Liu Y, Shao M, Wu Y, Yan C, Jiang S, Liu J, Dai J, Yang L, Li J, Jia W, Rui L,
Liu Y*. (2015) Role for the Endoplasmic Reticulum Stress Sensor IRE1α in Liver Regenerative Responses. J Hepatol. 62:590-98.
15) Zhang HS, Chen Y, Fan L, Xi QL, Wu GH, Li XX, Yuan TL, He SQ, Yu Y, Shao ML, Liu Y, Bai CG, Ling ZQ, Li M, Liu Y*, Fang J*. (2015) The Endoplasmic Reticulum Stress Sensor IRE1α in Intestinal Epithelial Cells Is Essential for Protecting against Colitis.J Biol Chem.290:15327-36.
Jiang S, Yan C, Fang QC, Shao ML, Zhang YL, Liu Y, Deng YP, Shan B, Liu JQ, Li HT, Yang L, Zhou J, Dai Z, Liu Y*, Jia WP*. (2014) Fibroblast Growth Factor 21 Is Regulated by the IRE1α-XBP1 Branch of the Unfolded Protein Response and Counteracts ER stress-induced Hepatic Steatosis. J Biol Chem. 289:29751-65.
(Selected as one of the Best JBC Papers of the Year
17) Xu T, Yang L, Yan C, Wang X, Huang P, Zhao F, Zhao L, Zhang M, Jia W, Wang X*, Liu Y*. (2014) The IRE1α-XBP1 pathway regulates metabolic stress-induced compensatory proliferation of pancreatic β-cells. Cell Res. 24:1137-40.
18) Shao M, Shan B, Liu Y, Deng Y, Yan C, Wu Y, Mao T, Qiu Y, Zhou Y, Jiang S, Jia W, Li J, Li J, Rui L, Yang L, Liu Y*. (2014) Hepatic IRE1α regulates fasting-induced metabolic adaptive programs through the XBP1s-PPARα axis signalling. Nat Commun. 5:3528.
Zhang Q, Liu B, Cheng Y, Meng Q, Xia T, Jiang L, Chen S, Liu Y*, Guo F*. (2014) Leptin signaling is required for leucine deprivation-enhanced energy expenditure. J Biol Chem. 289:1779-87.
20) Zhang C, Li S, Yang L, Huang P, Li W, Wang S, Zhao G, Zhang M, Pang X, Yan Z, Liu Y*, Zhao L*. (2013) Structural modulation of gut microbiota in life-long calorie-restricted mice. Nat Commun. 4:2163.
21) Zhang Y, Gan Z, Huang P, Zhou L, Mao T, Shao M, Jiang X, Chen Y, Ying H, Cao M, Li J, Li J, Zhang WJ, Yang L, Liu Y*. (2012)
A Role for Protein Inhibitor of Activated STAT1 (PIAS1) in Lipogenic Regulation through SUMOylation-independent Suppression of Liver X Receptors. J Biol Chem. 287(45):37973-85.
Yu Y, Sun Y, He S, Yan C, Rui L, Li W, Liu Y*. (2012) Neuronal Cbl controls biosynthesis of insulin-like peptides in Drosophila melanogaster. Mol Cell Biol. 32:3610-23.
Yang L, Huang P, Li F, Zhao L, Zhang Y, Li S, Gan Z, Lin A, Li W, Liu Y*. (2012) c-Jun amino-terminal kinase-1 mediates glucose-responsive upregulation of the RNA editing enzyme ADAR2 in pancreatic beta-cells. PLoS One 7:e48611.
Zhou B, Yang L, Li S, Huang J, Chen H, Hou L, Wang J, Green CD, Yan Z, Huang X, Kaeberlein M, Zhu L, Xiao H, Liu Y* and Han JD*. (2012) Midlife Gene Expressions Identify Modulators of Aging through Dietary Interventions. Proc. Natl. Acad. Sci. U.S.A. Plus. 109:E1201-9.
25) Mao T, Shao M, Qiu Y, Huang J, Zhang Y, Song B, Wang Q, Jiang L, Liu Yi, Han JD, Cao P, Li J, Gao X, Rui L, Qi L, Li W and Liu Y*. (2011) PKA Phosphorylation Couples Hepatic IRE1α to Glucagon Signaling in Glucose Metabolism. Proc. Natl. Acad. Sci. U.S.A. 108:15852-7.
26) Yang L, Zhao L, Gan Z, He Z, Xu J, Gao X, Wang X, Han W, Chen L, Xu T, Li W*, Liu Y*. (2010) Deficiency in RNA editing enzyme ADAR2 impairs regulated exocytosis. FASEB J. 24:3720-32.
27) Wang Q, Li S, Jiang L, Zhou Y, Li Z, Shao M, Li W, Liu Y*. (2010) Deficiency in hepatic ATP-citrate lyase affects VLDL-triglyceride mobilization and liver fatty acid compositions of mice. J. Lipid Res. 51:2516-26.
You J, Yu Y, Jiang L, Li W, Yu X, Gonzalez L, Yang G, Ke Z, Li W, Li C* and Liu Y*. (2010) Tyr985 signaling of leptin receptor as an age/diet-dependent switch in regulation of energy balance. Mol. Cell. Biol. 30:1650-9.
(Highlighted by Editor’s Choice, Science 139, 141, 2010 and Science Signaling
3, ec95, 2010)
29) Song W, Ren D, Li W, Jiang L, Cho KW, Huang P, Fan C, Song Y, Liu Y* and Rui L*. (2010) SH2B Regulation of Growth, Metabolism, and Longevity in Both Insects and Mammals. Cell Metab. 11:427-37.
30) Huang P, Li S, Shao M, Qi Q, Zhao F, You J, Mao T, Li W, Yan Z, Liu Y*. (2010) Calorie restriction and endurance exercise share potent anti-inflammatory function in adipose tissues in ameliorating diet-induced obesity and insulin resistance in mice. Nutr Metab. (Lond) 7:59.
31) Qiu Y, Mao T, Zhang Y, Shao M, You J, Ding Q, Chen Y, Wu D, Xie D, Lin X, Gao X, Kaufman RJ, Li W*, Liu Y*. (2010) A crucial role for RACK1 in regulation of glucose-stimulated IRE1α activation in pancreatic β-cells. Sci. Signal. 3, ra7.
32) Wang Q, Jiang L, Wang J, Li S, Yu Y, You J, Zeng R, Gao X, Rui L, Li W and Liu Y*. (2009) Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice. Hepatology. 49:1166-75.
33) Jiang L, Wang Q, Yu Y, Zhao F, Huang P, Zeng R, Qi RZ, Li W and Liu Y*. (2009) Leptin Contributes to the Adaptive Responses of Mice to High-fat Diet Intake through Suppressing the Lipogenic Pathway. PLoS One 4:e6884.
34) Jiang L, You J, Yu X, Gonzalez L, Yu Y, Wang Q, Yang G, Li W, Li C*,
Liu Y*. (2008) Tyrosine-dependent and -independent actions of leptin receptor in control of energy balance and glucose homeostasis. Proc. Natl. Acad. Sci. U.S.A. 105: 18619-24.
(Highlighted by Nature China
, 2008)
35) Qi Q, Yu Z, Ye X, Zhao F, Huang P, Hu F, Franco OH, Wang J, Li H, Liu Y*, Lin X*. (2007) Elevated retinol-binding protein 4 levels are associated with metabolic syndrome in Chinese people. J. Clin. Endocr. Metab. 92:4827-34.
36) Gan Z, Zhao L, Yang L,Huang P, Zhao F, Li W, Liu Y*. (2006) RNA editing by ADAR2 is metabolically regulated in pancreatic islets and β-cells. J. Biol. Chem. 281:33386-94.

职称 教授、 国家杰出青年基金获得者、博士 Professor, Recipient of National Outstanding Young Scientist Award of NSFC , Ph.D. 实验室地址 生命科学学院大楼1131
联系电话 68753463 Email liuyong31279@whu.edu.cn
入选时间 学科专业 细胞生物学
研究方向 细胞应激与代谢疾病