2012年 - 至今： J. Biol. Chem.杂志，编委
The molecular mechanisms linking cellular stress pathways and metabolic dysfunctions
致力于研究糖脂代谢调控的生理学机制和慢性炎性疾病的病理学基础。利用动物模型，在生理学水平上探索营养失衡、内质网应激与代谢紊乱的机制关联，深入了解免疫炎性疾病发生发展的分子病理学基础，为肥胖、2型糖尿病、脂肪性肝炎及衰老相关慢性疾病的防治探寻新的干预靶标。
Our research aims to elucidate the molecular mechanisms that link overnutrition, endoplasmic reticulum (ER) stress and metabolic/inflammatory disorders. Employing animal models, we attempt to dissect the physiological actions of the IRE1α arm of the unfolded protein response (UPR) in nutrient-sensing, metabolic control and immune homeostasis. Our studies will provide new insights into the pathogenic mechanisms underlying obesity, type 2 diabetes, NASH and other aging-related chronic inflammatory diseases.
1) Chen Y, Wu Z, Huang S, Wang X, He SJ, Liu L, Hu Y, Chen L, Chen P, Liu S, He SQ, Shan B, Zheng L, Duan S, Song Z, Jiang L, Wang QA, Gan Z, Song BL, Liu J, Rui LY, Shan M, Liu Y*. (2022) Adipocyte IRE1α promotes PGC1α mRNA decay and restrains adaptive thermogenesis. Nat Metab. 4(9):1166-1184.
2) Li Y, Huang S, Wang J, Dai J, Cai J, Yan S, He S, Wang P, Jianmiao Liu J, Liu Y*. (2022) Phosphorylation at Ser724 of the ER stress sensor IRE1α governs its activation state and limits ER stress-induced hepatosteatosis. J Biol Chem. 298(6):101997.
3) Cai J, Zhang X, Chen P, Li Y, Liu S, Liu Q, Zhang H, Wu Z, Song K, Liu J, Shan B*, Liu Y*. (2022) The ER stress sensor inositol-requiring enzyme 1α in Kupffer cells promotes hepatic ischemia-reperfusion injury. J Biol Chem. 298(1):101532.
4) He S, Fu T, Yu Y, Liang Q, Li L, Liu J, Zhang X, Zhou Q, Guo Q, Xu D, Chen Y, Wang X, Chen Y, Liu J, Gan Z, Liu Y*. (2021) IRE1α regulates skeletal muscle regeneration through Myostatin mRNA decay. J Clin Invest. 131(17):e143737.
5) Zhao P, Huang P, Xu T, Xiang X, Sun Y, Liu J, Yan C, Wang L, Gao J, Cui S, Wang X, Zhan L, Song H, Liu J, Song W*, Liu Y*. (2021) Fat body Ire1 regulates lipid homeostasis through the Xbp1s-FoxO axis in Drosophila. iScience. 24(8):102819.
6) Liu L, Cai J, Wang H, Liang X, Zhou Q, Ding C, Zhu Y, Fu T, Guo Q, Xu Z, Xiao L, Liu J, Yin Y, Fang L, Xue B, Wang Y, Meng ZX, He A, Li JL, Liu Y, Chen XW*, Gan Z*. (2019) Coupling of COPII vesicle trafficking to nutrient availability by the IRE1α-XBP1s axis. Proc Natl Acad Sci U S A. 116(24):11776-11785.
7) Huang S, Xing Y. and Liu Y*. (2019) Emerging roles for the ER stress sensor IRE1α in metabolic regulation and disease. J Biol. Chem. 294(49) 18726–18741. (Review)
8) Yan C, Liu J, Gao J, Sun Y, Zhang L, Song H, Xue L, Zhan L, Gao G, Ke Z, Liu Y*, Liu J*. (2019) IRE1 promotes neurodegeneration through autophagy-dependent neuron death in the Drosophila model of Parkinson's disease. Cell Death Dis. 10(11):800.
9) Wu Y, Shan B, Dai J, Xia Z, Cai J, Chen T, Lv S, Feng Y, Zheng L, Wang Y, Liu J, Fang J, Xie D, Rui L, Liu J, Liu Y*. (2018) Dual Role for Inositol-requiring Enzyme 1α in Promoting the Development of Hepatocellular Carcinoma during Diet-induced Obesity. Hepatology 68:533-546.
10) Shan B, Wang X, Wu Y, Xu C, Xia Z, Dai J, Shao M, Zhao F, He S, Yang L, Zhang M, Nan F, Li J, Liu J, Liu J, Jia W, Qiu Y, Song B, Han JJ, Rui L, Duan SZ*, Liu Y*. (2017) The Metabolic ER Stress Sensor IRE1α Suppresses Alternative Activation of Macrophages to Impair Energy Expenditure in Obesity. Nat Immunol. 18:519-529.
(Highlighted in News and Views, Nature Immunol. 18:479-480, 2017; Preview, Mol Cell 66:731-733, 2017; Nat Rev Immunol. 17:277, 2017; Nat Rev Endocrinol. 13:315, 2017)11) Xiao Y, Xia T, Yu J, Deng Y, Liu H, Liu B, Chen S, Liu Y*, Guo F*. (2016) Knockout of inositol-requiring enzyme 1α in pro-opiomelanocortin neurons decreases fat mass via increasing energy expenditure. Open Biol. 6(8). pii: 160131.
12) Wu J, Yang L, Li S, Huang P, Liu Y*, Wang Y*, Tang H*. (2016) Metabolomics Insights into the Modulatory Effects of Long-Term Low Calorie Intake in Mice. J Proteome Res. 15:2299-308.
13) Qiu Y*, Shan B, Yang L, Liu Y*. (2016) Adipose tissue macrophage in immune regulation of metabolism. Sci China Life Sci. 59:1232-1240. (Review)
14) Liu Y, Shao M, Wu Y, Yan C, Jiang S, Liu J, Dai J, Yang L, Li J, Jia W, Rui L, Liu Y*. (2015) Role for the Endoplasmic Reticulum Stress Sensor IRE1α in Liver Regenerative Responses. J Hepatol. 62:590-98.
15) Zhang HS, Chen Y, Fan L, Xi QL, Wu GH, Li XX, Yuan TL, He SQ, Yu Y, Shao ML, Liu Y, Bai CG, Ling ZQ, Li M, Liu Y*, Fang J*. (2015) The Endoplasmic Reticulum Stress Sensor IRE1α in Intestinal Epithelial Cells Is Essential for Protecting against Colitis.J Biol Chem.290:15327-36.
16) Jiang S, Yan C, Fang QC, Shao ML, Zhang YL, Liu Y, Deng YP, Shan B, Liu JQ, Li HT, Yang L, Zhou J, Dai Z, Liu Y*, Jia WP*. (2014) Fibroblast Growth Factor 21 Is Regulated by the IRE1α-XBP1 Branch of the Unfolded Protein Response and Counteracts ER stress-induced Hepatic Steatosis. J Biol Chem. 289:29751-65.
(Selected as one of the Best JBC Papers of the Year)
17) Xu T, Yang L, Yan C, Wang X, Huang P, Zhao F, Zhao L, Zhang M, Jia W, Wang X*, Liu Y*. (2014) The IRE1α-XBP1 pathway regulates metabolic stress-induced compensatory proliferation of pancreatic β-cells. Cell Res. 24:1137-40.
18) Shao M, Shan B, Liu Y, Deng Y, Yan C, Wu Y, Mao T, Qiu Y, Zhou Y, Jiang S, Jia W, Li J, Li J, Rui L, Yang L, Liu Y*. (2014) Hepatic IRE1α regulates fasting-induced metabolic adaptive programs through the XBP1s-PPARα axis signalling. Nat Commun. 5:3528.
19) Zhang Q, Liu B, Cheng Y, Meng Q, Xia T, Jiang L, Chen S, Liu Y*, Guo F*. (2014) Leptin signaling is required for leucine deprivation-enhanced energy expenditure. J Biol Chem. 289:1779-87.
20) Zhang C, Li S, Yang L, Huang P, Li W, Wang S, Zhao G, Zhang M, Pang X, Yan Z, Liu Y*, Zhao L*. (2013) Structural modulation of gut microbiota in life-long calorie-restricted mice. Nat Commun. 4:2163.
21) Zhang Y, Gan Z, Huang P, Zhou L, Mao T, Shao M, Jiang X, Chen Y, Ying H, Cao M, Li J, Li J, Zhang WJ, Yang L, Liu Y*. (2012) A Role for Protein Inhibitor of Activated STAT1 (PIAS1) in Lipogenic Regulation through SUMOylation-independent Suppression of Liver X Receptors. J Biol Chem. 287(45):37973-85.
22) Yu Y, Sun Y, He S, Yan C, Rui L, Li W, Liu Y*. (2012) Neuronal Cbl controls biosynthesis of insulin-like peptides in Drosophila melanogaster. Mol Cell Biol. 32:3610-23.
23) Yang L, Huang P, Li F, Zhao L, Zhang Y, Li S, Gan Z, Lin A, Li W, Liu Y*. (2012) c-Jun amino-terminal kinase-1 mediates glucose-responsive upregulation of the RNA editing enzyme ADAR2 in pancreatic beta-cells. PLoS One 7:e48611.
24) Zhou B, Yang L, Li S, Huang J, Chen H, Hou L, Wang J, Green CD, Yan Z, Huang X, Kaeberlein M, Zhu L, Xiao H, Liu Y* and Han JD*. (2012) Midlife Gene Expressions Identify Modulators of Aging through Dietary Interventions. Proc. Natl. Acad. Sci. U.S.A. Plus. 109:E1201-9.
25) Mao T, Shao M, Qiu Y, Huang J, Zhang Y, Song B, Wang Q, Jiang L, Liu Yi, Han JD, Cao P, Li J, Gao X, Rui L, Qi L, Li W and Liu Y*. (2011) PKA Phosphorylation Couples Hepatic IRE1α to Glucagon Signaling in Glucose Metabolism. Proc. Natl. Acad. Sci. U.S.A. 108:15852-7.
26) Yang L, Zhao L, Gan Z, He Z, Xu J, Gao X, Wang X, Han W, Chen L, Xu T, Li W*, Liu Y*. (2010) Deficiency in RNA editing enzyme ADAR2 impairs regulated exocytosis. FASEB J. 24:3720-32.
27) Wang Q, Li S, Jiang L, Zhou Y, Li Z, Shao M, Li W, Liu Y*. (2010) Deficiency in hepatic ATP-citrate lyase affects VLDL-triglyceride mobilization and liver fatty acid compositions of mice. J. Lipid Res. 51:2516-26.
28) You J, Yu Y, Jiang L, Li W, Yu X, Gonzalez L, Yang G, Ke Z, Li W, Li C* and Liu Y*. (2010) Tyr985 signaling of leptin receptor as an age/diet-dependent switch in regulation of energy balance. Mol. Cell. Biol. 30:1650-9.
(Highlighted by Editor’s Choice, Science 139, 141, 2010 and Science Signaling 3, ec95, 2010)
29) Song W, Ren D, Li W, Jiang L, Cho KW, Huang P, Fan C, Song Y, Liu Y* and Rui L*. (2010) SH2B Regulation of Growth, Metabolism, and Longevity in Both Insects and Mammals. Cell Metab. 11:427-37.
30) Huang P, Li S, Shao M, Qi Q, Zhao F, You J, Mao T, Li W, Yan Z, Liu Y*. (2010) Calorie restriction and endurance exercise share potent anti-inflammatory function in adipose tissues in ameliorating diet-induced obesity and insulin resistance in mice. Nutr Metab. (Lond) 7:59.
31) Qiu Y, Mao T, Zhang Y, Shao M, You J, Ding Q, Chen Y, Wu D, Xie D, Lin X, Gao X, Kaufman RJ, Li W*, Liu Y*. (2010) A crucial role for RACK1 in regulation of glucose-stimulated IRE1α activation in pancreatic β-cells. Sci. Signal. 3, ra7.
32) Wang Q, Jiang L, Wang J, Li S, Yu Y, You J, Zeng R, Gao X, Rui L, Li W and Liu Y*. (2009) Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice. Hepatology. 49:1166-75.
33) Jiang L, Wang Q, Yu Y, Zhao F, Huang P, Zeng R, Qi RZ, Li W and Liu Y*. (2009) Leptin Contributes to the Adaptive Responses of Mice to High-fat Diet Intake through Suppressing the Lipogenic Pathway. PLoS One 4:e6884.
34) Jiang L, You J, Yu X, Gonzalez L, Yu Y, Wang Q, Yang G, Li W, Li C*, Liu Y*. (2008) Tyrosine-dependent and -independent actions of leptin receptor in control of energy balance and glucose homeostasis. Proc. Natl. Acad. Sci. U.S.A. 105: 18619-24.
(Highlighted by Nature China, 2008)
35) Qi Q, Yu Z, Ye X, Zhao F, Huang P, Hu F, Franco OH, Wang J, Li H, Liu Y*, Lin X*. (2007) Elevated retinol-binding protein 4 levels are associated with metabolic syndrome in Chinese people. J. Clin. Endocr. Metab. 92:4827-34.
36) Gan Z, Zhao L, Yang L,Huang P, Zhao F, Li W, Liu Y*. (2006) RNA editing by ADAR2 is metabolically regulated in pancreatic islets and β-cells. J. Biol. Chem. 281:33386-94.
