教育经历/Education

武汉大学 学士/ Wuhan University Bachelor

武汉大学 硕士/Wuhan University Master

芝加哥洛约拉大学 博士/Loyola University Chicago, PhD

美国芝加哥大学肿瘤研究所 博士后/ University of Chicago Ben May Institute for Cancer Research Post-doctoral Fellow

美国西北大学医学院 博士后/Northwestern University Feinberg School of Medicine Post-doctoral Fellow

工作经历/Professional experience

上海市儿童医院 研究助理/Children’s Hospital of Shanghai Research Associate

Loyola University Chicago 研究助理/Research Associate

武汉大学生命科学学院 教授/ Wuhan University College of Life Sciences Professor

社会兼职/Professional Affiliation

美国血液学学会/American Society of Hematology

亚太医学生物免疫学会基础免疫学分会委员

湖北省医学生物免疫学会血液学分会学术委员会副主任

中国细胞生物学学会/Chinese Society for Cell Biology

中国生理学学会/Chinese Association for Physiological Sciences

主要研究方向

　　实验室致力于阐释细胞分化及其异常导致细胞恶变和肿瘤发生的分子机理，主要研究内容包括：1）阐释巨核细胞分化过程中核内有丝分裂的调控机理及其异常导致血细胞恶变的机制和相关干预策略；2）揭示肝癌演进发生的分子机制和生物标志物，探索新型治疗靶点和方法。实验室重点关注这些生理病理过程中的表观遗传、天然免疫和代谢重编程机制。

Research interests:

My laboratory is committed to elucidating the molecular basis of cell differentiation and its abnormalities leading to cellular malignancy and tumorigenesis. The main research contents include: 1) dissecting the regulatory mechanisms controlling endomitosis during megakaryocyte differentiation and how their dysregulation causes hematopoietic cell transformation and can be used for the development of intervention strategies; 2) revealing the molecular mechanisms and biomarkers of liver cancer evolution, and exploring novel therapeutic targets and strategies. My laboratory presently focuses on epigenetic, innate immunity, and metabolic reprogramming mechanisms regulating these pathophysiological processes.

教学课程/Course director

本科生：生物化学/Biochemistry for undergraduates

研究生：造血细胞发育与分化/Hematopoiesis for graduates

主持课题项目/Funding

1.　国自然青年科学基金项目（项目编号：30700412；2008-2010；主持）

2.　国自然面上项目（编号：81070406；2011-2013；主持）

3.　国自然面上项目（编号：31371481；2014-2017；主持）

4.　国自然面上项目（编号：81670140；2018-2021；主持）

5.　国自然面上项目（编号：81870427；2019-2022；主持）

6.　国自然重大研究计划（培育）（编号：91957109；2020-2022；主持）

7.　国自然面上项目（编号：32270643；2023-2026；主持）

8.　教育部博士点基金（编号：20110141110016；2012-2014；主持）

9.　教育部回国留学人员启动基金（2012；主持）

10.　教育部“新世纪优秀人才支持计划”（编号：NCET-12-0422；2013-2015；主持）

发表论文（#并列第一作者*通讯作者）/Selected Publications

1. Sun, J.; Ding, J.; Shen, Q.; Wang, X.; Wang, M.; Huang, Y.; Zhang, X.; Zhu, H.; Zhang, F.; Wu, D.; Peng, M.; Zhang, Z.; Yuan, Y.; Li, W.; She, Z. G.; Zhang, X. J.; Li, H.; Zhang, P.*; Huang, Z*. Decreased propionyl-CoA metabolism facilitates metabolic reprogramming and promotes hepatocellular carcinoma. J Hepatol. 2023, 78(3):627-642.
2. Sun, Jiaqi; Wang, Xiyang; Shen, Qingsong; Wang, Min; Chen, Shuxian; Zhang, Xuechun; Huang, Yongping; Zhang, Zhonglin; Li, Wenhua; Yuan, Yufeng; Huang, Zan. DNASE1L3 inhibits hepatocellular carcinoma by delaying cell cycle progression through CDK2. Cell Oncol (Dordr). 2022, 45(6):1187-1202.
3. Hu, Yufeng; He, Wenzhi; Huang, Yongping; Xiang, Hui; Guo, Juan; Che, Yan; Cheng, Xu; Hu, Fengjiao; Hu, Manli; Ma, Tengfei; Yu, Jie; Tian, Han; Tian, Song; Ji, Yan-Xiao; Zhang, Peng; She, Zhi-Gang; Zhang, Xiao-Jing; Huang, Zan*; Yang, Juan*; Li, Hongliang*. Fatty Acid Synthase-Suppressor Screening Identifies Sorting Nexin 8 as a Therapeutic Target for NAFLD. Hepatology. 2021, 74(5):2508-2525.
4. Yan, Zhen-Zhen; Huang, Yong-Ping; Wang, Xin; Wang, Hai-Ping; Ren, Fei; Tian, Rui-Feng; Cheng, Xu; Cai, Jie; Zhang, Yan; Zhu, Xue-Yong; She, Zhi-Gang; Zhang, Xiao-Jing*; Huang, Zan*; Li, Hongliang*. Integrated Omics Reveals Tollip as an Regulator and Therapeutic Target for Hepatic Ischemia-Reperfusion Injury in Mice. Hepatology. 2019, 70(5):1750-1769.
5. Yang, Xuejing; Lu, Bin; Sun, Xueqin; Han, Cuijuan; Fu, Chunling; Xu, Kailin; Wang, Min; Li, Dengju; Chen, Zhichao; Opal, Puneet; Wen, Qiang; Crispino, John D; Wang, Qian-Fei*; Huang, Zan*. ANP32A regulates histone H3 acetylation and promotes leukemogenesis. Leukemia. 2018, 32(7):1587-1597.
6. Wang, Xiaozhan; Mao, Wenzhe; Fang, Chun; Tian, Song; Zhu, Xueyong; Yang, Ling; Huang, Zan*; Li, Hongliang*. Dusp14 protects against hepatic ischaemia-reperfusion injury via Tak1 suppression. J Hepatol. 2018, 68(1):118-129.
7. Qin, Juan-Juan; Mao, Wenzhe; Wang, Xiaozhan; Sun, Peng; Cheng, Daqing; Tian, Song; Zhu, Xue-Yong; Yang, Ling; Huang, Zan*; Li, Hongliang*. Caspase recruitment domain 6 protects against hepatic ischemia/reperfusion injury by suppressing ASK1. J Hepatol. 2018, 69(5):1110-1122.
8. Yan, Feng-Juan; Zhang, Xiao-Jing; Wang, Wen-Xin; Ji, Yan-Xiao; Wang, Pi-Xiao; Yang, Yang; Gong, Jun; Shen, Li-Jun; Zhu, Xue-Yong; Huang, Zan*; Li, Hongliang*. The E3 ligase tripartite motif 8 targets TAK1 to promote insulin resistance and steatohepatitis. Hepatology. 2017, 65(5):1492-1511.
9. Sun, Xueqin; Lu, Bin; Han, Cuijuan; Qiu, Wanlin; Jin, Qi; Li, Dengju; Li, Qiubai; Yang, Qiong; Wen, Qiang; Opal, Puneet; Kini, Ameet R; Crispino, John D; Huang, Zan. ANP32A dysregulation contributes to abnormal megakaryopoiesis in acute megakaryoblastic leukemia. Blood Cancer J. 2017, 7(12):661-665.
10. Lu, Bin; Ren, Yujie; Sun, Xueqin; Han, Cuijuan; Wang, Hongyan; Chen, Yuxuan; Peng, Qianqian; Cheng, Yongbo; Cheng, Xiaoliang; Zhu, Qiyun; Li, Wenxin; Li, Hong-Liang; Du, Hai-Ning; Zhong, Bo*; Huang, Zan*. Induction of INKIT by Viral Infection Negatively Regulates Antiviral Responses through Inhibiting Phosphorylation of p65 and IRF3. Cell Host Microbe. 2017, 22(1):86-98 e84.
11. Jin, Qi; Ren, Yi; Wang, Min; Suraneni, Praveen; Li, Dengju; Crispino, John; Fan, Jingyi*; Huang, Zan*. Novel function of FAXDC2 in megakaryopoiesis. Blood Cancer J. 2016, 6(9):e478.
12. Lu, Bin; Sun, Xueqin; Chen, Yuxuan; Jin, Qi; Liang, Qin; Liu, Shangqin; Li, Yamu; Zhou, Yan; Li, Wenxin; Huang, Zan. Novel function of PITH domain-containing 1 as an activator of internal ribosomal entry site to enhance RUNX1 expression and promote megakaryocyte differentiation. Cell Mol Life Sci. 2015, 72(4):821-832.
13. Lin, Yi; Li, Dengju; Liang, Qing; Liu, Shangqing; Zuo, Xuelan; Li, Lin; Sun, Xuemei; Li, Wenxin; Guo, Mingxiong*; Huang, Zan*. miR-638 regulates differentiation and proliferation in leukemic cells by targeting cyclin-dependent kinase 2. J Biol Chem. 2015, 290(3):1818-1828.
14. Sun, Xueqin; Lu, Bin; Hu, Bo; Xiao, Wuhan; Li, Wenxin; Huang, Zan. Novel function of the chromosome 7 open reading frame 41 gene to promote leukemic megakaryocyte differentiation by modulating TPA-induced signaling. Blood Cancer J. 2014, 4:e198.
15. Liu, Lu; Wen, Qiang; Gong, Rui; Gilles, Laure; Stankiewicz, Monika J; Li, Wenhua; Guo, Mingxiong; Li, Lin; Sun, Xuemei; Li, Wenxin; Crispino, John D; Huang, Zan. PSTPIP2 dysregulation contributes to aberrant terminal differentiation in GATA-1-deficient megakaryocytes by activating LYN. Cell Death Dis. 2014, 5:e988.
16. Khan, Irum#; Huang, Zan#; Wen, Qiang; Stankiewicz, Monika J; Gilles, Laure; Goldenson, Benjamin; Schultz, Rachael; Diebold, Lauren; Gurbuxani, Sandeep; Finke, Christy M; Lasho, Terra L; Koppikar, Priya; Pardanani, Animesh; Stein, Brady; Altman, Jessica K; Levine, Ross L; Tefferi, Ayalew; Crispino, John D. AKT is a therapeutic target in myeloproliferative neoplasms. Leukemia. 2013, 27(9):1882-1890.
17. Huang, Zan; Dore, Louis C; Li, Zhe; Orkin, Stuart H; Feng, Gang; Lin, Simon; Crispino, John D. GATA-2 reinforces megakaryocyte development in the absence of GATA-1. Mol Cell Biol. 2009, 29(18):5168-5180.
18. Huang, Zan; Richmond, Terri D; Muntean, Andrew G; Barber, Dwayne L; Weiss, Mitchell J; Crispino, John D. STAT1 promotes megakaryopoiesis downstream of GATA-1 in mice. J Clin Invest. 2007, 117(12):3890-3899.

专利/Patent

1.  Dimethyl fasudil for inducing polyploidization of megakaryocytes and for treating blood and bone marrow diseases and disorders. John D. Crispino; Qiang Wen; Zan Huang; Andrew M. Stern; Robert J. Gould. 2015.1.13, 美国, US 8933071 B2, 授权
2.  用于制备肝癌检测试剂的新型代谢标志物及其应用；黄赞、孙佳琪；2023.02.21，中国，ZL 2022 1 0337336.1，授权
3.  用于制备治疗肝癌药物的代谢物及其应用；黄赞、孙佳琪；2023.06.01，中国，ZL 2022 1 0072182.8，授权
4. 用于制备治疗肝癌药物的新型代谢标志物及其应用；黄赞、孙佳琪；2022.07.29，中国，CN114807289A，实质审查

5. 靶向ANP32A抗白血病的小分子肽及其制备方法和应用；黄赞、王曼曼、张昙；2021.09.03，中国，CN113336829A，实质审查