学习经历

1986-1990年 武汉大学生命科学学院 生物化学专业 获学士学位

1993-1996年 武汉大学生命科学学院 生物化学专业 获硕士学位

1996-1999年 武汉大学生命科学学院 微生物学专业 获博士学位

主要工作经历与任职情况

讲 师 1999-2001年 武汉大学生命科学学院

助 研 1999-2000年 香港理工大学应用生物及化学学系

博士后 2001-2003年 美国肯塔基大学生物化学学系

副教授 2001-2009年 武汉大学生命科学学院

教 授 2009-现 在 武汉大学生命科学学院

主要社会兼职

湖北省生物物理学会理事长（2012-2018）

湖北省神经科学学会理事会常务理事（2017-2022）

主要研究领域与兴趣

1.抗肿瘤药物筛选及其抗肿瘤机制的研究。

2.阿尔兹海默症发病机制以及雌激素神经保护的研究。

承担课程（本科生、研究生）

1. 主讲《生物化学技术原理极其应用》(本科生)。

2. 主讲《专业文献研读》(本科生)。

3. 主讲《神经生物学》(研究生)。

4. 教材《生物化学技术原理极其应用》第五版，副主编，科学出版社。

主持课题项目

国家自然科学基金面上项目（31870786）

国家自然科学基金面上项目（31371331）

国家自然科学基金面上项目（30970914）

国家自然科学基金二个基地项目（30740420548）

国家自然科学基金面上项目（30670647）

湖北省自然科学基金（2007ABA115）

湖北省自然科学基金（2006ABA219）

湖北省科技攻关计划项目（2006AA301B31）

湖北省高等学校教学研究项目（20062022）

教育部留学回国人员科研启动基金（2004527）

代表性论文（*通讯作者）

1.Jun Wu, Jing Yan, Pingping Fang, Hai-bing Zhou, Kaiwei Liang∗, Jian Huang∗. Three-dimensional oxabicycloheptene sulfonate targets the homologous recombination and repair programmes through estrogen receptor α antagonism. Cancer Letters. 469: 78–88. (2020).

2.Chen Cheng, Nan Zheng, Deyang Sun, Weishuo Fang, Lingling Zheng, Weihong Song,Jian Huang*. A Novel Compound YS‑5‑23 Exhibits Neuroprotective Effect by Reducing β‑Site Amyloid Precursor Protein Cleaving Enzyme 1’s Expression and H2O2‑Induced Cytotoxicity in SH‑SY5Y Cells. Neurochemical Research. 45:2113–2127. (2020).

3.Pan Huang, Nan Zheng, Hai-bing Zhou,Jian Huang*. Curcumin inhibits BACE1 expression through the interaction between ERβ and NFκB signaling pathway in SH-SY5Y cells. Molecular and Cellular Biochemistry. 463:161–173. (2020).

4.Ming He, Wentao Ning, Zhiye Hu,Jian Huang, Chune Dong, Hai-Bing Zhou. Design, synthesis and biological evaluation of novel dual-acting modulators targeting both estrogen receptor a (ERa) and lysine specific demethylase 1 (LSD1) for treatment of breast cancer. European Journal of Medicinal Chemistry. 195,112281. (2020).

5.Qiuyu Meng, Xiaoyu Ma, Baohua Xie, Xiaofei Deng,Jian Huang,Hai-Bing Zhou and Chune Dong. Establishment of evaluation criteria for the development of high quality ERα-targeted fluorescent probes. Analyst. 145, 5989. (2020).

6.De-Yang Sun, Chen Cheng, Katrin Moschke,Jian Huangand Wei-Shuo Fang*. Extensive Structure Modification on Luteolin-Cinnamic Acid Conjugates Leading to BACE1 Inhibitors with Optimal Pharmacological Properties. Molecules. 25, 102. (2020).

7.Yue Zhao, Chenxi Zhao, Jin Lua, Jun Wu, Changhao Li, Zhiye Hu, Wei Tian, Liang Yang, Jin Xiang, Haibin Zhou, Zixin Deng,Jian Huang∗, Kui Hong∗. Sesterterpene MHO7 suppresses breast cancer cells as a novel estrogen receptor degrader, Pharmacological Research. 146: 104294. (2019).

8.Wei-Shuo Fang, De-yang Sun, Shuang Yang, Chen Cheng, Katrin Moschkec, Tianqi Li, Shanshan Sun, Stefan F. Lichtenthalerc,Jian Huang, YinghongWang*. Discovery ofa series of selective and cell permeable beta-secretase (BACE1) inhibitors by fragment linking with the assistance of STD-NMR. Bioorg Chem. 92:103253. (2019).

9.Zhiye Hu, Yuanyuan Li, Baohua Xie, Wentao Ning, Yuan Xiao, Yuan Huang, Chenxi Zhao,Jian Huang*, Chune Dong*, Hai-Bing Zhou*. Novel class of 7-Oxabicyclo[2.2.1]heptene sulfonamides with long alkyl chains displayingimproved estrogen receptor α degradation activity. Eur J Med Chem. 8;182:111605. (2019).

10.Yong Wei, Jiawei Zhou, Jun Wu,Jian Huang*. ERβ promotes Aβ degradation via the modulation of autophagy. Cell Death Dis. 10(8):565. (2019).

11.Yong Wei,Jian Huang*. Role of estrogen and its receptors mediated-autophagy in cell fate and human diseases. The Journal of Steroid Biochemistry and Molecular Biology. 191, 105380. (2019).

12.Yong Wei, Can Huang, Haoyu Wu,Jian Huang*. Estrogen Receptor Beta (ERβ) Mediated-CyclinD1 Degradation via Autophagy Plays an Anti-Proliferation Role in Colon Cells. Int J Biol Sci. 15(5):942-952. (2019).

13.Yuanyuan Li, Silong Zhang, Jing Zhang, Zhiye Hu, Yuan Xiao,Jian Huang, Chune Dong, Shengtang Huang, Hai-Bing Zhou*. Exploring the PROTAC degron candidates: OBHSA with different side chains as novel selective estrogen receptor degraders (SERDs) chains as novel selective estrogen receptor degraders (SERDs). European Journal of Medicinal Chemistry.172 48-61. (2019).

14.Wentao Ning, Zhiye Hu, Chu Tang, Lu Yang, Silong Zhang, Chune Dong,Jian Huang, and Hai-Bing Zhou*. Novel Hybrid Conjugates with Dual Suppression of Estrogenic and Inflammatory Activities Display Significantly Improved Potency against Breast Cancer. J Med Chem. 61(18):8155-8173. (2018).

15.Jing Dong, Nan Zheng, Xue Wang, Chu Tang, Yan ping*, Hai‑Bing Zhou*,Jian Huang*. A novel HDAC6 inhibitor exerts an anti-cancer effect by triggering cell cycle arrest and apoptosis in gastric cancer. Eur J Pharmacol. 828:67-79. (2018).

16.Junjie Luo, Zhiye Hu, Yuan Xiao, Tongxin Yang, Chune Dong,Jian Huangand Hai-Bing Zhou⁎. Rational design and optimization of selenophenes with basic side chains as novel potent selective estrogen receptor modulators (SERMs) for breast cancer therapy. Med. Chem. Commun. 8(7): 1485-1497.（2017）.

17.Yuzhi Lu, Jun Li, Chun-E Dong,Jian Huang, Hai-Bing Zhou⁎,Wei Wang⁎. Recent advances in gossypol derivatives and analogs: a chemistry and biology view. Future Med Chem. 9(11):1243-1275.（2017）.

18.Lu Yang, Zhiye Hu, Junjie Luo, Chu Tang, Silong Zhang, Wentao Ning, Chune Dong,Jian Huang,Xianjun Liu, Hai-Bing Zhou. Dual functional small molecule fluorescent probes for image-guided estrogen receptor-specific targeting coupled potent antiproliferative potency for breast cancer therapy. Bioorg Med Chem.1;25(13):3531-3539.（2017）.

19.Lijuan Deng, Chen Cheng, Jun Wu, Caihua Wang, Hai‑Bing Zhou*,Jian Huang*. Oxabicycloheptene Sulfonate Protects Against β-Amyloid-induced Toxicity by Activation of PI3K/Akt and ERK Signaling Pathways Via GPER1 in C6 Cells. Neurochem Res. 42(8):2246-2256.（2017）.

20.Xue Wang, Nan Zheng, Jing Dong, Xuming Wang, Lijiang Liu⁎,Jian Huang⁎. Estrogen receptor-α36 is involved in icaritin induced growth inhibition of triple-negative breast cancer cells. J Steroid Biochem Mol Biol. 171:318-327.(2017).

21.Silong Zhang, Zhiyong Wang, Zhiye Hu, Changhao Li, Chu Tang, Kathryn E. Carlson, Junjie Luo, Chune Dong, John A. Katzenellenbogen,Jian Huang* and Hai-Bing Zhou*. Selenophenes: Introducing a New Element into the Core of Non-Steroidal Estrogen Receptor Ligands. Chem Med Chem. 12(3):235-249.(2017).

22.Huiping Xie, Zhimin Xiao andJian Huang∗. C6 Glioma-Secreted NGF and FGF2 Regulate Neuronal APP Processing Through Up-Regulation of ADAM10 and Down-Regulation of BACE1, Respectively. J Mol Neurosci. 59(3):334-42. (2016).

23.Changhao Li, Chu Tang, Zhiye Hu, Chenxi Zhao, Chenlu Li, Silong Zhang, Chune Dong, Hai-Bing Zhou∗ andJian Huang∗. Synthesis and structure–activity relationships of novel hybrid ferrocenyl compounds based on a bicyclic core skeleton for breast cancer therapy. Bioorg Med Chem. 24(13):3062-74. (2016).

24.Can Huang, Peng Yuan, Jun Wu andJian Huang∗. Estrogen regulates excitatory amino acid carrier 1 (EAAC1) expression through sphingosine kinase 1 (SphK1) transacting FGFR-mediated ERK signaling in rat C6 astroglial cells. Neuroscience. 319: 9-22. (2016).

25.Chu Tang, Changhao Li, Silong Zhang, Zhiye Hu, Jun Wu, Chune Dong*,Jian Huang* and Hai-Bing Zhou*. Novel Bioactive Hybrid Compound Dual Targeting Estrogen Receptor and Histone Deacetylase for the Treatment of Breast Cancer. J Med Chem. 58(11):4550-72. (2015).

26.Dan Tong, Janice Ortega, Christine Kim,Jian Huang, Liya Gu, Guo-Min Li. Arsenic Inhibits DNA Mismatch Repair by Promoting EGFR Expression and PCNA Phosphorylation. J Biol Chem. 290(23): 14536–14541. (2015).

27.Huijun Zeng, Pan Huang, Xue Wang, Jun Wu, Min Wu,Jian Huang*. Galangin-induced down-regulation of BACE1 by epigenetic mechanisms in SH-SY5Y cells. Neuroscience. 294:172-81. (2015).

28.Nan Zheng, Peng Yuan, Changhao Li, Jun Wu,Jian Huang*. Luteolin Reduces BACE1 Expression through NF-κB and Estrogen Receptor Mediated Pathways in HEK293 and SH-SY5Y Cells. J Alzheimers Dis. 45: 659–671. (2015).

29.Caihua Wang, Changhao Li, Haibing Zhou andJian Huang*. High-Throughput Screening Assays for Estrogen Receptor by Using Coumestrol, a Natural Fluorescence Compound. J Biomol Screen. 19(2):253-8. (2014).

30.Zhimin Xiao, Can Huang, Jun Wu, Li Sun, Wei Hao, Lai K. Leung,Jian Huang*. The neuroprotective effects of ipriflavone against H2O2 and amyloid beta induced toxicity on human neuroblastoma SH-SY5Y cells. Eur J Pharmacol. 721: 286–293 (2013).

31.Wenjuan Tan, Tsz Yan Wong, Yanfei Wang,Jian Huang, Lai K. Leung*. CYP19 expression is induced by 2,3,7,8-tetrachloro-dibenzo-para-dioxin in human glioma cells. Mol Cell Endocrinol. 15;375(1-2):106-12. (2013).

32.Nelson L. S. Chan, Jinzhen Guo, Tianyi Zhang, Guogen Mao, Caixia Hou, Fenghua Yuan,Jian Huang, Yanbin Zhang, Jianxin Wu, Liya Gu, and Guo-Min Li*. Coordinated processing of 3' slipped (CAG)n/(CTG)n hairpins by DNA polymerases β and δ preferentially induces repeat expansions. J Biol Chem. 288(21): 15015–15022, (2013).

33.Xinlong Zhang, Ziqing Zuo, Juan Tang, Kai Wang, Caihua Wang, Weiyan Chen, Changhao Li, Wen Xu, Xiaolin Xiong, Kangxiang Yuntai,Jian Huang, Xiaoli Lan, Hai-Bing Zhou*. Design, synthesis and biological evaluation of novel estrogen-derived steroid metal complexes. Bioorg Med Chem Lett. 1;23(13):3793-7. (2013).

34.Feng Li, Guogen Mao, Dan Tong,Jian Huang, Liya Gu, Wei Yang and Guo-Min Li*. The Histone Mark H3K36me3 Regulates Human DNA Mismatch Repair through Its Interaction with MutSα. Cell. 153(3):590-600. (2013).

35.Yangfan Zheng, Caihua Wang, Changhao Li, Jinxia Qiao, Feng Zhang, Minjian Huang, Wenming Ren, Chune Dong,Jian Huang* and Hai-Bing Zhou*. Discovery of novel SERMs with a ferrocenyl entity based on the oxabicyclo[2.2.1]heptene scaffold and evaluation of their antiproliferative effects in breast cancer cells. Org. Biomol. Chem., 10: 9689. (2012).

36.Nelson L. S. Chan, Caixia Hou, Tianyi Zhang, Fenghua Yuan, Amrita Machwe,Jian Huang, David K. Orren,Liya Gu, and Guo-Min Li∗. The Werner syndrome protein promotes CAG/CTG repeat stability by resolving large (CAG)(n)/(CTG)(n) hairpins. J Biol Chem. 287(36):30151-6. (2012).

37.Hsiang-Tsui Wang, YuHu, Dan Tong,Jian Huang, Liya Gu, Xue-Ru Wu, Fung-Lung Chung, Guo-Min Li,and Moon-shong Tang∗. Effect of Carcinogenic Acrolein on DNA Repair and Mutagenic Susceptibility. J Biol Chem. 287(15): 12379–86. (2012).

38.Tianyi Zhang,Jian Huang∗, Liya Gu, Guo-Min Li∗. In vitro repair of DNA hairpins containing various numbers of CAG/CTG trinucleotide repeats. DNA Repair, 11: 201–209. (2012).

39.Peng Yuan, Kaiwei Liang, Buyong Ma, Nan Zheng, Ruth Nussinov, andJian Huang*. Multiple-Targeting and Conformational Selection in the Estrogen Receptor: Computation and Experiment. Chem Biol Drug Des, 78: 137–149. (2011).

40.Caixia Hou, Tianyi Zhang, Lei Tian,Jian Huang, Liya Gu, Guo-Min Li*. The Role of XPG in Processing (CAG)n/(CTG)n DNA Hairpins. Cell & Bioscience, 1:11-17. (2011).

41.Kaiwei Liang, Liuqing Yang, Chen Yin, Zhimin Xiao, Junjian Zhang, Yumin Liu andJian Huang*, Estrogen stimulates degradation of {beta}-amyloid peptide by upregulating neprilysin. J Biol Chem. 285(2):935-42. (2010).

42.Zhi-Min Xiao; Li Sun; Yu-Min Liu; Jun-Jian Zhang;Jian Huang*, Estrogen Regulation of the Neprilysin Gene Through A Hormone-Responsive Element. Journal of Molecular Neuroscience, 39:22-6. (2009).

43.Kaiwei Liang, Liuqing Yang, Zhimin Xiao andJian Huang*, A Bipartite Recombinant Yeast System for the Identification of Subtype-Selective Estrogen Receptor Ligands. Molecular Biotechnology, 41:53–62, (2009).

44.Li-Juan Deng, Yan Xu,Jian Huang*, Developing a double-antigen sandwich ELISA for effective detection of human hepatitis B core antibody. Comp Immunnol Microb, 31: 515-26. (2008).

45.Guogen Mao, Xiaoyu Pan, Bei-Bei Zhu, Yanbin Zhang, Fenghua Yuan,Jian Huang, Mark A. Lovell, Maxwell P. Lee, William R. Markesbery, and Guo-Min Li, Liya Gu. Identification and characterization of OGG1 mutations in patients with Alzheimer’s disease. Nucleic Acids Research, 35(8):2759-66. (2007).

46.Huang, J., Guan, H., Booze, R. M., Eckman, C. B., Hersh, L.B. Estrogen regulates neprilysin activity in rat brain. Neurosci Lett. 367(1):85-7. (2004)．

47.Deming Gou, Jun Wang, Li Gao, Yan Sun, Xiao Peng,Jian Huang, Wenxin Li. Identification and functional analysis of a novel Human KRAB/C2H2 zinc finger gene ZNF300. Biochimica et biophysica acta, 1676 (3):203-209. (2004 ).

48.Huang, J., Gou, D. M., Zhen, C. Y., Jiang, D. H., Mao, X., Li, W. X. Protection of xenogeneic cells from human complement-mediated lysis by expression of human DAF, CD 59 and MCP. FEMS Immunology and Medical Microbiology, 31(3):203-9. (2001).

49.Gou DM; Sun Y; Gao L; Chow LM;Huang J; Feng YD; Jiang DH; Li WX. Cloning and characterization of a novel Kruppel-like zinc finger gene, ZNF268, expressed in early human embryo. Biochimica et biophysica acta, ,1518(3):306-10. (2001).