该室主要从事信号转导，肿瘤发生，以及mRNA调控方面的研究。实验室详细信息请参考http://www.feinberg.northwestern.edu/

目前研究的主要方向有：

1. 研究CD44及其差异剪切转录本涉及的信号通路。应用分子细胞生物学、生物化学以及生物信息学的方法研究联系CD44和其下游信号通路的信号及效应途径。

2. 研究CD44在肿瘤形成中的作用。基于小鼠模型，探讨CD44在体内肿瘤形成中的机制。

3. 阐明可变剪切在基因调控中的机制。阐明决定可变剪切中差异的信号事件以及可变剪切影响信号通路的结果及其与疾病的关系。我们也研究小RNA在肿瘤形成中的作用。

申请者应熟练掌握分子生物学、细胞生物学实验技术以及RNA相关研究和癌症研究。具有高度的热情与责任感，明确的职业规划。请有意申请者将个人简历及联系方式以电子邮件方式发给：

Dr. Chonghui Cheng

Northwestern University Feinberg School of Medicine

Department of Medicine

Robert H. Lurie Comprehensive Cancer Center

303 East Superior Street

Chicago, IL 60611

邮件地址：chengc@northwestern.edu

也可先联系本院黄赞教授z-huang@whu.edu.cn

请申请者在邮件标题中注明“postdoc application”

2010.6.17

原文：

Positions for postdoctoral scholar are available in the Laboratory of Dr. Chonghui Cheng at Northwestern University Feinberg School of Medicine to study signal transduction, tumor progression, and/or mRNA regulation. Current research in the Cheng lab focuses on the following areas:

1. Investigating the mechanism by which CD44 and its splice isoforms modulate signaling cascades. We are using molecular and cellular biological methods, in conjunction with bioinformatics and biochemical approaches, to dissect the signaling and effector pathways that link CD44 and downstream signaling pathways.

2. Dissecting the role of CD44 in cancer progression. We have developed mouse models to determine whether and how CD44 contribute to tumor progression in vivo. We will also explore the underlying mechanisms of CD44 in carcinogenesis.

3. Understanding mechanisms of gene regulation by alternative splicing. Recent results indicated that most genes in humans undergo alternative splicing, generating different splice isoforms that possess diverse functions. We are interested in determining signaling events that govern the change in alternative splicing, as well as the consequences of alternative splicing in affecting signaling and diseases. We are also interested in the role of microRNAs in tumorigenesis.

Successful applicants must have excellent experimental expertise in molecular and cell biology, RNA biology, and/or cancer research and should be highly motivated and career-oriented. To apply, please email a curriculum vitae and names/contact information of three references to:

Dr. Chonghui Cheng

Northwestern University Feinberg School of Medicine

Department of Medicine

Robert H. Lurie Comprehensive Cancer Center

303 East Superior Street

Chicago, IL 60611

Email:chengc@northwestern.edu

(You can also contact with Dr. Zan Huang at WuHan University first :

z-huang@whu.edu.cn)

Please indicate “postdoc application” in the subject line.