珞珈讲坛第308讲
时 间：2019年10月24日（周四）15：30
地 点：武汉大学生命科学学院二楼报告厅
主讲人：季维智 中国科学院院士
题 目：逆水行舟，不进则退：灵长类生殖与发育研究
主讲人简介：
季维智， 1950年生，博士生导师，中国科学院院士，昆明理工大学特聘教授，灵长类转化医学研究院院长，云南省灵长类生物医学动物重点实验室理事长，生物医学动物模型国家地方联合工程研究中心主任。季维智院士是“世界经济论坛全球未来理事会”理事（2016-2018）、“国家干细胞研究指导协调委员会”专家、“国家重大科学研究计划生殖与发育专家组”成员(2006-2014)、“国家实验动物研究委员会”专家组成员、973项目首席科学家。
季维智院士长期坚持灵长类研究，围绕灵长类早期胚胎发育调控，干细胞多能性和人类疾病的猴模型及致病机理等科学问题，形成了从体外受精、胚胎早期发育、基因编辑以及干细胞等系统研究体系。在灵长类生殖和发育的分子机制，干细胞的自我更新和分化调控等方面都有新的发现，在国际上首次获得了猴多能性干细胞，开启了靶向基因编辑建立灵长类动物模型的研发和应用。
季维智院士长期为国家生殖发育、干细胞专家组服务，为中国生殖与干细胞研究作出了突出贡献，也为中国灵长类研究的国际化并跻身于世界先进行列发挥了重要作用。承担多项国家级重点研发项目，包括科技部973计划“细胞多能性和人类重大疾病的猴模型研究”、“猕猴干细胞自我更新、定向分化的分子机制”、“非人灵长类克隆及治疗性克隆的机理研究”、科技部国家科技支撑计划“人类疾病的灵长类动物模型开发和标准化研究”及科技部863计划“灵长类动物模型与安全性评价的研究与应用”等。在 Cell，Cell Stem Cell，PNAS，JBC，Stem Cell Reports, Biomaterials, Stem Cells，Biol. Reprod.，Hum. Reprod.等杂志以通讯作者或第一作者发表 SCI 论文 70 余篇。其中，2014 年在 Cell 发表的基因编辑猴的论文被评价为人类疾病模型建立的里程碑性工作、入选 2014 年世界十大科技进展（MIT）、2014 年 Cell 最佳论文(Cell)、 2014 年世界最成功的 8 大事件之一(Nature)。
Brief Introduction of Professor Weizhi Ji
Prof. Weizhi Ji currently is Member of Chinese Academy of Sciences, Professor and Director of Yunnan Key Laboratory of Primate Biomedical Research/ Institute of Primate Translational Medicine, Kunming University of Science and Technology. In 1985-1987, Prof. Ji worked as a scientist in Oregon National Primate Research Center and Smithsonian Institution in US. Since 1996 till 2005, he had served as the director of Kunming Institute of Zoology, Chinese Academy of Sciences. In the meantime, from 1995 to 1997, he held visiting professor position in University of Wisconsin. In 1996, Prof. Ji was named as the director of China-US Joint Primate Biology Laboratory, which was co-established by Kunming Institute of Zoology and Wisconsin Primate Research Center.
Prof. Ji has been engaged in primate reproductive biology research since 1980s and he takes the lead in primate stem cell research in China. His lab reported the first gene-modified rhesus and cynomolgus monkeys via Cas9/RNA-mediated gene targeting in 2014, first proved the feasibility of generate chimeric monkeys using ESCs in 2015 and revealed global DNA de novo methylation during monkey pre-implantation development. His team has established human, monkey, rabbit and mouse embryonic stem cell lines and adult stem cell lines. His study found the mechanism of embryonic stem cells differentiate into neural stem cells in vivo and the integration mechanisms in vitro. Now his research focuses on generation of transgenic monkeys, primate embryonic development, stem cell self-renewal mechanisms and stem cell replacement therapy research, where he has published a lot of articles in high level magazines of this area, such as Cell, Cell Stem Cells, PNAS, Biology of Reproduction, Human Reproduction and other magazines.
