报告题目：Covalent Bonding of Chemistry and Biology
　　　　　共价阻剂在生物研究及药物研发中的应用

报 告 人：张超　美国南加州大学化学系/生物科学系 副教授（tenured）

报告时间： 2019年10月18日 下午3点

报告地点： 生科院一楼中厅

报告人简介：

　　报告人主要从事化学遗传学，激酶抑制剂和化学蛋白质组学方面的研究。开发和应用信号蛋白化学调节剂，特别是涉及癌症和自身免疫的化学调节剂，来更好地理解正常和异常信号传导，并加速这些疾病的新疗法的开发。

　　此次报告中，张超教授将讲述他的研究团队运用化学遗传学和化学蛋白组学两种互补的方法高效发现针对多家族蛋白的共价阻剂的研究结果。

报告题目：Mechanisms of Epigenetic Inheritance

报 告 人：张志国教授
　　　　　Professor of Pediatrics and Professor of Genetics and Development
　　　　　Institute for Cancer Genetics
　　　　　Columbia University

报告时间：2019年10月25日上午 10:00

报告地点: 生科院一楼中厅

Research Interests:

We are interested in determining how epigenetically determined chromatin states are inherited during S phase of the cell cycle and how alterations in this process impact genome instability. We are using yeast, mouse embryonic stem cells as well as human cells to address this fundamental question in the chromatin and epigenetic field. Currently, we are focusing on determining how nucleosomes, the basic repeat unit of chromatin, are assembled following DNA replication. Second, we are interested in determining how epigenetic alterations contribute to tumorigenesis and drug resistance. Towards this goal, we are focusing on determining how mutations on histones promote tumorigenesis using brain and bone tumors as models and how epigenetic changes drive drug resistance in brain tumors.