报告题目：多粘菌素MCR类耐药：肠道细菌“表面”文章
报 告 人：冯友军 教授　浙江大学医学院/动物科学学院
报告时间：2018年11月15日上午10:00
报告地点：生命科学学院一楼中厅
报告人简介:

　　冯友军博士系浙江大学医学院和动物科学学院的双聘教授，博士生导师。长期致力于细菌脂肪酸及其衍生物 (生物素和类脂A) 的新功能研究。围绕“细菌脂肪酸与致病/耐药性”这一重要科学问题开展研究。主要研究成果包括以下三个方面：⑴建立脂肪酸代谢的新调控机制与细菌毒力之间的关系；⑵探明脂肪酸衍生物—生物素的代谢机制与致病性偶联；⑶揭示脂肪酸衍生物—类脂A的结构修饰与耐药性相关。在Trends Microbiol、PLoS Pathogens、PLoS Genetics、mBio、Mol Microbiol等微生物学领域主流期刊发表100余篇研究论文。目前主持国家自然科学基金重点项目1项、面上项目2项。作为重要成员荣获2011年度中华医学一等奖、2011年度中华预防医学一等奖以及2014年度国家科技进步二等奖。目前担任Virulence 与Frontiers in Cellular and Infection Microbiology等国际刊物的编委。

近2年发表的主要论文 (2016-2018)：
1. Sun J#, Zhang H#, Liu YH*, Feng Y*. Towards understanding MCR-like colistin resistance. Trends in Microbiology 2018, 7. pii: S0966-842X (18)30042-8.
2. Wei W#, Srinivas S#, Lin J#, Tang Z#, Wang S, Ullah S, Kota VG, Feng Y*, Defining ICR-Mo, an intrinsic colistin resistance determinant from Moraxella osloensis. PLoS Genet 2018, 14(5): e1007389.
3. Xu Y#, Zhong L#, Srinivas S#, Sun J#, Paterson DL, Lei S, Lin J, Li X, Tang Z, Feng S, Shen C, Tian GB*, Feng Y*. Spread of MCR-3 Colistin Resistance in China: An Epidemiological, Genomic and Mechanistic Study. EbioMedicine 2018, 34: 139-157.
4. Wei W#, Zhang Y#, Gao R#, Li J, Xu Y, Wang S, Ji Q*, Feng Y*. Crystal structure and acetylation of BioQ suggests a novel regulatory switch for biotin biosynthesis in Mycobacterium smegmatis. Mol Microbiol 2018,109(5): 642-662.
5. Gao R, Hu YF, Li ZC, Sun J, Wang QJ, Lin JX, Ye HY, Liu F, Srinivas S, Li DF, Zhu BL, Liu YH, Tian GB, Feng Y*. Dissemination and mechanism for the MCR-1 colistin resistance. PLoS Pathogens 2016, 12 (11): e1005957.
6. Xu Y#, Wei W#, Lei S#, Lin J, Srinivas S, Feng Y*. An evolutionarily-conserved mechanism for intrinsic and transferable polymyxin resistance. mBio 2018, In press.
7. Sun J, Xu Y, Gao R, Lin J, Wei W, Srinivas S, Li D, Yang RS, Li XP, Liao XP, Liu YH, Feng Y*. Deciphering MCR-2 colistin resistance. mBio 2017, 8(3). pii: e00625-17.
8. Ye H, Li Y, Li Z, Gao R, Zhang H, Wen R, Gao GF, Hu Q, Feng Y*. Diversified mcr-1-harbouring plasmid reservoirs confer resistance to colistin in human gut microbiota. mBio 2016, 7(2). pii: e00177-16.
9. Xu Y#, Lin J#, Cui T#, Srinivas S, Feng Y*. Mechanistic insights into transferable polymyxin resistance among gut bacteria. J Biol Chem 2018, jbc.RA117.000924.
10. Wang Q, Sun J, Li J, Ding Y, Li XP, Lin JX, Hassan B, Feng Y*. Expanding landscapes of the diversified mcr-1-bearing plasmid reservoirs. Microbiome 2017, 5(1):70.
11. Feng Y*. Transferability of MCR-1/2 polymyxin resistance: Complex dissemination and genetic mechanism. ACS Infect Dis 2018, 4(3):291-300.
12. Wang Q, Sun J, Ding Y, Li XP, Liu YH, Feng Y*. Genomic insights into mcr-1-positive plasmids carried by the colistin-resistant Escherichia coli from the inpatients. Antimicrob Agents Chemother 2017, pii: AAC.00361-17.
13. Gao R, Wang Q, Li P, Li Z, Feng Y*. Genome sequence and characteristics of plasmid pWH12, a variant of the mcr-1-harbouring plasmid pHNSHP45, from the multi-drug resistant E. coli. Virulence 2016, 7(6):732-5
14. Lv J#, Mohsin M#, Lei S#, Srinivas S, Wiqar R, Lin J, Feng Y*. Discovery of a mcr-1-bearing plasmid in commensal colistin-resistant Escherichia coli from healthy broilers in Faisalabad, Pakistan. Virulence 2018, 18:1-13.
15. Mao J, Liu W, Wang W, Sun J, Lei S, Feng Y*. Antibiotic exposure elicits the emergence of colistin- and carbapenem-resistant Escherichia coli coharboring MCR-1 and NDM-5 in a patient. Virulence 2018, 9(1):1001-1007.
16. Chavda B, Lv J, Hou M, Chavda KD, Kreiswirth BN, Feng Y*, Chen L*, Yu F*. Coidentification of mcr-4.3 and blaNDM-1 in a Clinical Enterobacter cloacae Isolate from China. Antimicrob Agents Chemother 2018, 62(10). pii: e00649-18.