Zishu Pan
Zishu Pan
PhD, Professor of Virology & Immunology
State Key Laboratory of Virology
College of Life Sciences, Wuhan University, Wuhan, 430072, China
Research Interests
1. Molecular mechanisms of genome replication and innate antiviral immunity of RNA viruses like influenza A viruses and classical swine fever virus.
2. Approaches to new vaccines against viral pathogens
Tel: +86-27-6875 2833
Email: zspan@whu.edu.cn
Recent Publications
1. Pan Tao, Mengcheng Luo, Ruangang Pan, Dawei Ling, Siyu Zhou, Po Tien, Zishu Pan. (2009). Enhanced protective immunity against H5N1 influenza virus challenge by vaccination with DNA expressing a chimeric hemagglutinin in combination with an MHC class I-restricted epitope of nucleoprotein in mice. Antiviral Research 81, 253-260.
2. Xuelian Luo, Ruangang Pan, Chao Wan, Xinfeng Liu, Jianguo Wu, Zishu Pan. (2009). Glycosylation of classical swine fever virus E(rns) is essential for binding double-stranded RNA and preventing interferon-beta induction. Virus Research 146,135-139.
3. Guoyuan Wen, Jinnuo Xue, Yanping Shen, Chuyu Zhang, Zishu Pan. (2009). Characterization of classical swine fever virus (CSFV) nonstructural protein 3 (NS3) helicase activity and its modulation by CSFV RNA-dependent RNA polymerase. Virus Research 141, 63-70.
4. Pan Tao, Mengcheng Luo, Dandan Zhu, Sanfu Qu, Zhenhua Yang, Meng Gao, Deyin Guo, Zishu Pan. (2009).Virus-like particle vaccine comprised of the HA, NA, and M1 proteins of an avian isolated H5N1 influenza virus induces protective immunity against homologous and heterologous strains in mice. Viral Immunology 22,273-281
5. Mengcheng Luo, Pan Tao, Junwei Li, Siyu Zhou, Deyin Guo, Zishu Pan. (2008). Immunization with plasmid DNA encoding influenza A virus nucleoprotein fused to a tissue plasminogen activator signal sequence elicits strong immune responses and protection against H5N1 challenge in mice. Journal of Virological Methods 154,121–127.
6. Yi Wang, Qin Wang, Xiaolu Lu, Chuyu Zhang, Xuezheng Fan, Zishu Pan, et al., (2008). 12-nt insertion in 3' untranslated region leads to attenuation of classic swine fever virus and protects host against lethal challenge. Virology 374,390-398.