Wenxin Li
Tel: 86 - 27 - 6875-2831
Fax: 86 - 27 - 6875-6746
College of Life Sciences, Wuhan University
Research Interests:
(1) Structure-function relationship of scorpion venom peptides;
(2) The relationship between human early embryonic genes and tumors.
Recent publications:
(1) Song Han, Hong Yi, Shi-Jin Yin, Zong-Yun Chen, Hui Liu, Zhi-Jian Cao, Ying-Liang Wu, and Wen-Xin Li. Structural Basis of a Potent Peptide Inhibitor Designed for Kv1.3 Channel, a Therapeutic Target of Autoimmune Disease. J Biol Chem, 2008, 283: 19058-19065
(2) Shijin Yin, Ling Jiang, Hong Yi, Song Han, Daiwen Yang, Maili Liu, Hui Liu, Zhijian Cao, Yingliang Wu, Wenxin Li. Different residues in channel turret determining the selectivity of ADWX-1 inhibitor peptide between Kv1.1 and Kv1.3 channels. Journal of Proteome Research, 2008, 7(11): 4890-4897
(3) Dai C, Ma Y, Zhao Z, Zhao R, Wang Q, Wu Y, Cao Z, Li W. Mucroporin, the first cationic host defence peptide from the venom of Lychas mucronatus. Antimicrob Agents Chemother, 2008, 52(11): 3967-3972
(4) Yibao Ma, Ruiming Zhao, Yawen He, Songryong Li, Jun Liu, Yingliang Wu, Zhijian Cao and Wenxin Li. Transcriptome analysis of the venom gland of the scorpion Scorpiops jendeki: implication for the evolution of the scorpion venom arsenal. BMC Genomics, 2009 Jul 1;10:290
(5) Zhenhuan Zhao, Yibao Ma, Chao Dai, Ruiming Zhao, SongRyong Li, Yingliang Wu, Zhijian Cao, and Wenxin Li. Imcroporin, a New Cationic Antimicrobial Peptide from the Venom of the Scorpion Isometrus maculates. Antimicrob Agents Chemother, 2009, 83：3472-3477.
(6) Hong Yi, Zhijian Cao, Shijin Yin, Chao Dai, Yingliang Wu, Wenxin Li. Interaction Simulation of hERG K+ Channel with its specific Bekm-1 peptide: Insights into the Selectivity of Molecular Recognition. Journal of Proteome Research, 2007, 6: 611-620
(7) Di Wang, Ming-Xiong Guo, Zhou-Zhou Zhao, Hong-Ling Qiu, Hai-Ming Hu, Huan-Jie Shao, Chen-Gang Zhu, Lu Xue, Yun-Bo Shi and Wen-Xin Li. Human T-cell leukemiavirus type 1 oncoprotein tax represses ZNF268 expression through the cAMP-responsive Element-binding Protein/Activating Transcription Factor pathway. J. Biol. Chem., 2008, 283(24): 16299-308.
(8) Xin Mao, Chunrong Yu, Wenhua Li, Wenxin Li. Induction of apoptosis by shikonin through a ROS/JNK-mediated process in Bcr/Abl-positive chronic myelogenous leukemia (CML) cells. Cell Res., 2008, 18(8): 879-88.
(9) Ming-Xiong Guo, Di Wang, Huan-Jie Shao, Hong-Ling Qiu, Lu Xue, Zhou-Zhou Zhao, Chen-Gang Zhu, Yun-Bo Shi, and Wen-Xin Li. Transcription of Human Zinc Finger ZNF268 Gene Requires an Intragenic Promoter Element. J. Biol. Chem., 2006, 281(34): 24623-36.
