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 YONG LIU

Professor, Recipient of National Outstanding Young Scientist Award of NSFC , Ph.D.

 

Contact

Email: liuyong31279@whu.edu.cn

Phone: 027-68753463

 

Education

1989.09-1995.01：Rutgers University, PhD, USA

1986.09-1989.07：Peking University, Master's Degree

1982.09-1986.07：Peking University, Bachelor's Degree

 

Professional Experience

2015.09 - Now： College of Life Sciences, Wuhan University

2003.07-2015.08：Institute for Nutritional Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences

2000.11-2003.07：AlleCure/Mankind Corp., CA, USA

1995.03-2000.10：Department of MCDB, University of California at Santa Barbara, CA, USA

 

Social Part-time Jobs

2012 -Now：Journal of Biological Chemistry, Editorial Board Member

 

Awards and Honors

2009 National Science Foundation for Outstanding Young Scholars
        2009 Meiji Dairy Life Science Excellence Award
        2010 Shanghai Outstanding Discipline Leader
        2010 Backbone of the Innovation Group of the National Natural Science Foundation of China
        2011 Special allowance of the State Council
        2011 WuXi AppTec Biochemistry Research Award
        2012 Chief Scientist of the National Major Scientific Research 973 Program
        2012 Shanghai Leading Talent

 

Research Fields

The molecular mechanisms linking cellular stress pathways and metabolic dysfunctions

ER stress in the molecular pathogenesis of inflammatory diseases

 

Research Description

Our research aims to elucidate the molecular mechanisms that link overnutrition, endoplasmic reticulum (ER) stress and metabolic/inflammatory disorders. Employing animal models, we attempt to dissect the physiological actions of theIRE1αarm of the unfolded protein response (UPR) in nutrient-sensing, metabolic control and immune homeostasis. Our studies will provide new insights into the pathogenic mechanisms underlying obesity, type 2 diabetes, NASH and other aging-related chronic inflammatory diseases.

 

Research Project

2021.01-2025.12 国家自然科学基金创新研究群体项目，脂代谢的稳态调控与重编程，骨干

2019.09-2024.08 国家科技部重点研发计划，应激对组织器官代谢稳态和发育的调控作用与机制，主持

2019.01-2022.12 国家自然科学基金重大研究计划，内质网应激感应分子IRE1α的代谢性激活在代谢稳态中的调控作用与机制，主持

2017.01-2021.12 国家自然科学基金重大项目，介导脂代谢可塑性的重要细胞器及其调控机制，主持

 

Selected Publications

Cai J, Zhang X, Chen P, Li Y, Liu S, Liu Q, Zhang H, WuZ, Song K, Liu J, Shan B*,Liu Y*. (2022)The ER stress sensor inositol-requiring enzyme 1αin Kupffer cells promotes hepatic ischemia-reperfusion injury.J Biol Chem. 298(1):101532.

He S, Fu T, Yu Y, Liang Q, Li L, Liu J, Zhang X, Zhou Q, Guo Q, Xu D, Chen Y, Wang X, Chen Y, Liu J, Gan Z,Liu Y*. (2021) IRE1α regulates skeletal muscle regeneration through Myostatin mRNA decay.J Clin Invest. 131(17):e143737.

Zhao P, Huang P, Xu T, Xiang X, Sun Y, Liu J, Yan C, Wang L, Gao J, Cui S, Wang X, Zhan L, Song H, Liu J, Song W*,Liu Y*. (2021) Fat body Ire1 regulates lipid homeostasis through the Xbp1s-FoxO axis in Drosophila.iScience. 24(8):102819.

Liu L, Cai J, Wang H, Liang X, Zhou Q, Ding C, Zhu Y, Fu T, Guo Q, Xu Z, Xiao L, Liu J, Yin Y, Fang L, Xue B, Wang Y, Meng ZX, He A, Li JL,Liu Y, Chen XW*, Gan Z*. (2019) Coupling of COPII vesicle trafficking to nutrient availability by the IRE1α-XBP1s axis.Proc Natl Acad Sci U S A. 116(24):11776-11785.

Huang S, Xing Y. andLiu Y*.(2019) Emerging roles for the ER stress sensor IRE1α in metabolic regulation and disease.J Biol. Chem.294(49) 18726–18741. (Review)

Yan C, Liu J, Gao J, Sun Y, Zhang L, Song H, Xue L, Zhan L, Gao G, Ke Z,Liu Y*, Liu J*. (2019) IRE1 promotes neurodegeneration through autophagy-dependent neuron death in the Drosophila model of Parkinson's disease.Cell Death Dis.10(11):800.

Wu Y,Shan B, Dai J, Xia Z, Cai J, Chen T, Lv S, Feng Y, Zheng L, Wang Y, Liu J, Fang J, Xie D, Rui L, Liu J,Liu Y*. (2018)Dual Role for Inositol-requiring Enzyme 1α in Promoting the Development of Hepatocellular Carcinoma during Diet-induced Obesity.Hepatology68:533-546.

Shan B, Wang X, Wu Y, Xu C, Xia Z, Dai J, Shao M, Zhao F, He S, Yang L, Zhang M, Nan F, Li J, Liu J, Liu J, Jia W, Qiu Y, Song B, Han JJ, Rui L, Duan SZ*,Liu Y*.(2017)The Metabolic ER Stress Sensor IRE1α Suppresses Alternative Activation of Macrophages to Impair Energy Expenditure in Obesity.Nat Immunol.18:519-529.

(Highlighted inNews and Views,Nature Immunol.18:479-480, 2017;Preview,Mol Cell66:731-733, 2017;Nat Rev Immunol.17:277, 2017;Nat Rev Endocrinol.13:315, 2017)

Xiao Y,Xia T,Yu J,Deng Y,Liu H,Liu B,Chen S,Liu Y*,Guo F*. (2016) Knockout of inositol-requiring enzyme 1α in pro-opiomelanocortin neurons decreases fat mass via increasing energy expenditure.Open Biol.6(8). pii: 160131.

Wu J, Yang L, Li S, Huang P,Liu Y*, Wang Y*, Tang H*. (2016) Metabolomics Insights into the Modulatory Effects of Long-Term Low Calorie Intake in Mice.J Proteome Res. 15:2299-308.

Qiu Y*, Shan B, Yang L,Liu Y*. (2016) Adipose tissue macrophage in immune regulation of metabolism.Sci China Life Sci.59:1232-1240. (Review)

Liu Y, Shao M, Wu Y, Yan C, Jiang S, Liu J, Dai J, Yang L, Li J, Jia W, Rui L,Liu Y*. (2015) Role for the Endoplasmic Reticulum Stress Sensor IRE1α in Liver Regenerative Responses.J Hepatol.62:590-98.

Zhang HS, Chen Y, Fan L, Xi QL, Wu GH, Li XX, Yuan TL, He SQ, Yu Y, Shao ML, Liu Y, Bai CG, Ling ZQ, Li M,Liu Y*, Fang J*. (2015) The Endoplasmic Reticulum Stress Sensor IRE1α in Intestinal Epithelial Cells Is Essential for Protecting against Colitis.J Biol Chem.290:15327-36.

Jiang S, Yan C, Fang QC, Shao ML, Zhang YL, Liu Y, Deng YP, Shan B, Liu JQ, Li HT, Yang L, Zhou J, Dai Z,Liu Y*, Jia WP*. (2014)Fibroblast Growth Factor 21 Is Regulated by the IRE1α-XBP1 Branch of the Unfolded Protein Response and Counteracts ER stress-induced Hepatic Steatosis.J Biol Chem. 289:29751-65.

(Selected as one of theBest JBC Papers of the Year)

Xu T, Yang L, Yan C, Wang X, Huang P, Zhao F, Zhao L, Zhang M, Jia W, Wang X*,Liu Y*.(2014) The IRE1α-XBP1 pathway regulates metabolic stress-induced compensatory proliferation of pancreatic β-cells.Cell Res.24:1137-40.

Shao M, Shan B, Liu Y, Deng Y, Yan C, Wu Y, Mao T, Qiu Y, Zhou Y, Jiang S, Jia W, Li J, Li J, Rui L, Yang L,LiuY*. (2014) Hepatic IRE1α regulates fasting-induced metabolic adaptive programs through the XBP1s-PPARα axis signalling.Nat Commun.5:3528.

Zhang Q,Liu B,Cheng Y,Meng Q,Xia T,Jiang L,Chen S,Liu Y*,Guo F*. (2014) Leptin signaling is required for leucine deprivation-enhanced energy expenditure.J Biol Chem.289:1779-87.

Zhang C, Li S, Yang L, Huang P, Li W, Wang S, Zhao G, Zhang M, Pang X, Yan Z,LiuY*, Zhao L*. (2013) Structural modulation of gut microbiota in life-long calorie-restricted mice.Nat Commun.4:2163.

Zhang Y, Gan Z, Huang P, Zhou L, Mao T, Shao M, Jiang X, Chen Y, Ying H, Cao M, Li J, Li J, Zhang WJ, Yang L,Liu Y*. (2012)A Role for Protein Inhibitor of Activated STAT1 (PIAS1) in Lipogenic Regulation through SUMOylation-independent Suppression of Liver X Receptors.J Biol Chem.287(45):37973-85.

Yu Y,Sun Y,He S,Yan C,Rui L,Li W,Liu Y*. (2012) Neuronal Cbl controls biosynthesis of insulin-like peptides in Drosophila melanogaster.Mol Cell Biol.32:3610-23.

Yang L,Huang P,Li F,Zhao L,Zhang Y,Li S,Gan Z,Lin A,Li W,Liu Y*.(2012) c-Jun amino-terminal kinase-1 mediates glucose-responsive upregulation of the RNA editing enzyme ADAR2 in pancreatic beta-cells.PLoS One7:e48611.

Zhou B,Yang L,Li S,Huang J,Chen H,Hou L,Wang J,Green CD,Yan Z,Huang X,Kaeberlein M,Zhu L,Xiao H,Liu Y* andHan JD*. (2012) Midlife Gene Expressions Identify Modulators of Aging through Dietary Interventions.Proc. Natl. Acad.Sci. U.S.A. Plus.109:E1201-9.

Mao T, Shao M, Qiu Y, Huang J, Zhang Y, Song B, Wang Q, Jiang L, Liu Yi, Han JD, Cao P, Li J, Gao X, Rui L, Qi L, Li W andLiu Y*. (2011) PKA Phosphorylation Couples HepaticIRE1αto Glucagon Signaling in Glucose Metabolism.Proc. Natl. Acad.Sci. U.S.A.108:15852-7.

Yang L, Zhao L, Gan Z, He Z, Xu J, Gao X, Wang X, Han W, Chen L, Xu T, Li W*,Liu Y*. (2010)Deficiency in RNA editing enzyme ADAR2 impairs regulated exocytosis.FASEB J. 24:3720-32.

Wang Q, Li S, Jiang L, Zhou Y, Li Z, Shao M, Li W,Liu Y*. (2010) Deficiency in hepatic ATP-citrate lyase affects VLDL-triglyceride mobilization and liver fatty acid compositions of mice.J. Lipid Res. 51:2516-26.

You J, Yu Y, Jiang L, Li W, Yu X, Gonzalez L, Yang G, Ke Z, Li W, Li C* andLiu Y*. (2010) Tyr⁹⁸⁵signaling of leptin receptor as an age/diet-dependent switch in regulation of energy balance.Mol. Cell. Biol. 30:1650-9.

(Highlighted byEditor’s Choice,Science139, 141, 2010 andScience Signaling3, ec95, 2010)

Song W, Ren D, Li W, Jiang L, Cho KW, Huang P, Fan C, Song Y,Liu Y* and Rui L*. (2010) SH2B Regulation of Growth, Metabolism, and Longevity in Both Insects and Mammals.Cell Metab. 11:427-37.

Huang P, Li S, Shao M, Qi Q, Zhao F, You J, Mao T, Li W, Yan Z,Liu Y*. (2010) Calorie restriction and endurance exercise share potent anti-inflammatory function in adipose tissues in ameliorating diet-induced obesity and insulin resistance in mice.Nutr Metab.(Lond)7:59.

Qiu Y, Mao T, Zhang Y, Shao M, You J, Ding Q, Chen Y, Wu D, Xie D, Lin X, Gao X, Kaufman RJ, Li W*,Liu Y*. (2010) A crucial role for RACK1 in regulation of glucose-stimulated IRE1α activation in pancreatic β-cells.Sci. Signal. 3, ra7.

Wang Q, Jiang L, Wang J, Li S, Yu Y, You J, Zeng R, Gao X, Rui L, Li W andLiu Y*.(2009) Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice.Hepatology. 49:1166-75.

Jiang L, Wang Q, Yu Y, Zhao F, Huang P, Zeng R, Qi RZ, Li W andLiu Y*. (2009) Leptin Contributes to the Adaptive Responses of Mice to High-fat Diet Intake through Suppressing the Lipogenic Pathway.PLoS One4:e6884.

Jiang L, You J, Yu X, Gonzalez L, Yu Y, Wang Q, Yang G, Li W, Li C*,Liu Y*.(2008) Tyrosine-dependent and -independent actions of leptin receptor in control of energy balance and glucose homeostasis.Proc. Natl. Acad.Sci. U.S.A.105: 18619-24.

(Highlighted byNature China, 2008)

Qi Q, Yu Z, Ye X, Zhao F, Huang P, Hu F, Franco OH, Wang J, Li H,Liu Y*, Lin X*. (2007) Elevated retinol-binding protein 4 levels are associated with metabolic syndrome in Chinese people.J. Clin. Endocr. Metab. 92:4827-34.

Gan Z, Zhao L, Yang L,Huang P, Zhao F, Li W,Liu Y*. (2006) RNA editing by ADAR2 is metabolically regulated in pancreatic islets and β-cells.J. Biol. Chem.281:33386-94.

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