郭明雄副教授

学科专业

细胞生物学

研究方向

肿瘤细胞生物学/微生物生态学

实验室位置

武汉大学生命科学学院4019室

联系电话

13343469985

Email

guomx@whu.edu.cn

学习经历

2003.09 – 2006.12 武汉大学生命科学学院 博士

2000.09 – 2003.06 武汉大学生命科学学院 硕士

1990.09 – 1994.06 武汉大学生命科学学院 学士


主要工作经历与任职情况

1. 2020.08 - 至今 西藏大学理学院(援藏) 副院长、副教授/教授、博士研究生导师

2. 2009.11 - 至今 武汉大学生命科学学院 副教授、硕士研究生导师

3. 2012.01 - 2012.12 美国纽约州奥尔巴尼医学院 访问学者

4. 2007.02 - 2009.11 武汉大学生命科学学院 讲师

5. 1994.07 - 2000.08 湖北中医药大学基础部 教师


主要社会兼职

1. 中国细胞生物学学会会员

2. 中国生物化学与分子生物学学会会员


主要科研奖励和个人荣誉

1. 国家级一流本科课程负责人

2. 国家虚拟仿真实验教学项目负责人

3. 武汉大学2017-2018学年本科优秀教学业绩奖

4. 武汉大学2016-2018年度优秀工会工作者


承担课程

1. 本科生:免疫学实验

2. 研究生:病毒与细胞的关系;细胞生物学研究前沿


主持课题项目

1. 国家自然科学基金地区科学基金项目(32260173),2023-2026

2. 国家自然科学基金面上项目(31871427),2019-2022

3. 湖北省自然科学基金面上项目(2018CFB548),2018-2019

4. 国家自然科学基金应急管理项目(31741081),2018-2018

5. 中央高校基本科研业务费专项资金(学科交叉类资助项目)(2042014kf0243),2014-2015

6. 深圳市科技创新委员会知识创新计划基础研究项目(JCYJ20140419141154250),2014-2016

7. 国家自然科学基金面上项目(31271511),2013-2016

8. 国家自然科学基金面上项目(30871245),2009-2011

9. 教育部高校博士点基金新教师项目(200804861004),2009-2011


发表的论文(#并列第一作者,*通讯作者)

1. Sen Yuan#, Jiaqi Xu#, Min Wang#, Junsong Huang, Shuangshuang Ma, Yang Liu, Yujia Ke, Xianhuang Zeng, Kangwei Wu, Jingwen Wang, Xuezhang Tian, Dandan Zheng, Tanzeel Yousaf, Wajeeha Naz, Junwei Sun, Lang Chen, Deyin Guo, Mingxiong Guo*, Guihong Sun*. HBV X protein induces degradation of UBXN7, a novel negative regulator of NF-κB signaling, to promote HBV replication. Cellular and Molecular Gastroenterology and Hepatology, 2022, https://doi.org/10.1016/j.jcmgh.2022.09.003.
2. Yang Liu#, Jingwen Wang#, Jianwen Chen#, Shaoshuai Wu#, Xianhuang Zeng, Qiushuang Xiong, Yandan Guo, Junwei Sun, Feifei Song, Zhepeng Liu, Fengxing Huang, Jiaqi Xu, Sen Yuan, Chuang Li, Shuting Guo, Ming Wang, Kun Li, Lang Chen, Yun-Bo Shi, Mingxiong Guo*, Deyin Guo*, Guihong Sun*. Upregulation of miR-520c-3p by HBV Enhances Tumor Cell Migration and Invasion by Activating NF-κB Signaling via PTEN-AKT Pathway. Molecular Therapy-Nucleic Acids, 2022, 29: 47-63.
3. Chuang Li, Wei Wang, Yuting Sun, Yifan Ni, Fang Qin, Xiaolu Li, Tao Wang, Mingxiong Guo*, Guihong Sun*. Selective sorting and secretion of hY4 RNA fragments into extracellular vesicles mediated by methylated YBX1 to promote lung cancer progression. Journal of Experimental & Clinical Cancer Research, 2022, 41(1), 136.
4. Chuang Li#, Fang Qin#, Wei Wang, Yifan Ni, Mingyu Gao, Mingxiong Guo*, and Guihong Sun*. hnRNPA2B1-mediated extracellular vesicles sorting of miR-122-5p potentially promotes lung cancer progression. International Journal of Molecular Sciences, 2021, 22(23), 12866.
5. Yi Liu, Wei Yin, Jingwen Wang, Yucong Lei, Guihong Sun, Wenxin Li, Zan Huang*, Mingxiong Guo*. KRAB-zinc finger protein ZNF268a deficiency attenuates the virus-induced pro-inflammatory response by preventing IKK complex assembly. Cells-Basel, 2019, 8, 1604.
6. Chuang Li, Fang Qin, Mengmeng Xue, Yucong Lei, Fen Hu, Hui Xu, Guihong Sun, Tao Wang*, Mingxiong Guo*. miR-429/-424-5p inhibit cell proliferation and Ca2+ influx by targeting CASR in pulmonary artery smooth muscle cells. American Journal of Physiology-Cell Physiology, 2019, 316(1): C111-C120.
7.
Jingwen Wang, Jianwen Chen, Yang Liu, Xianhuang Zeng, Mingcong Wei, Shaoshuai Wu, Qiushuang Xiong, Feifei Song, Xu Yuan, Yu Xiao, Yun Cao, Changyong Li, Lang Chen, Mingxiong Guo, Yun-Bo Shi, Guihong Sun, Deyin Guo. Hepatitis B Virus Induces Autophagy to Promote its Replication by the Axis of miR-192-3p-XIAP Through NF kappa B Signaling. Hepatology. 2019, 69(3): 974-992.
8. Chuang Li#, Fang Qin#, Fen Hu, Hui Xu, Guihong Sun, Guang Han, Tao Wang*, Mingxiong Guo*. Characterization and selective incorporation of small non-coding RNAs in non-small cell lung cancer extracellular vesicles. Cell and Bioscience, 2018, 8: 2.

9. Mingyang He, Weiwei Zhou, Chuang Li, Mingxiong Guo*. MicroRNAs, DNA Damage Response, and Cancer Treatment. International Journal of Molecular Sciences, 2016, 17(12): 2087.

10. Mingyang He, Yi Lin, Yunlan Tang, Yi Liu, Weiwei Zhou, Chuang Li, Guihong Sun*, Mingxiong Guo*. miR-638 suppresses DNA damage repair by targeting SMC1A expression in terminally differentiated cells. Aging-US, 2016, 8(7): 1442-1456.
11. Zhirong Bao#, Mingyang He#, Hong Quan*, Dazhen Jiang, Yanhong Zheng, Wenjing Qin, Yunfeng Zhou, Feng Ren, Mingxiong Guo* and Changzhong Jiang*. FePt nanoparticles: a novel nanoprobe for enhanced HeLa cells sensitivity to chemoradiotherapy. RSC advances, 2016, 6, 35124-34.

12. Yunlan Tang, Yi Lin, Chuang Li, Xunwu Hu, Yi Liu, Mingyang He, Jun Luo, Guihong Sun, Tao Wang, Wenxin Li, Mingxiong Guo*. MicroRNA-720 promotes in vitro cell migration by targeting Rab35 expression in cervical cancer cells. Cell and Bioscience, 2015, 5: 56.
13. Yi Lin, Dengju Li, Qing Liang, Shangqing Liu, Xuelan Zuo, Lin Li, Xuemei Sun, Wenxin Li, Mingxiong Guo*, Zan Huang*. miR-638 regulates differentiation and proliferation in leukemic cells by targeting cyclin-dependent kinase 2.
Journal of Biological Chemistry, 2015, 290(3): 1818-1828.
14.
Hongmei Cui, Mingxiong Guo, Dong Xu, Zhi-Chun Ding, Gang Zhou, Han-Fei Ding, Junran Zhang, Yi Tang & Chunhong Yan. The stress-responsive gene ATF3 regulates the histone acetyltransferase Tip60. Nature Communications, 2015, 6:6752
15. Wei Wang, Jinyang Cai, Yi Lin, Zikou Liu, Qihao Ren, Li Hu, Zan Huang, Mingxiong Guo*, and Wenxin Li*. Zinc Fingers Function Cooperatively with KRAB Domain for Nuclear Localization of KRAB-containing Zinc Finger Proteins. PLoS One, 2014, 9(3): e92155.
16. Yi Lin, Yan Zeng, Fan Zhang, Lu Xue, Zan Huang, Wenxin Li*, Mingxiong Guo*. Characterization of MicroRNA Expression Profiles and the Discovery of Novel MicroRNAs Involved in Cancer during Human Embryonic Development. PLoS One, 2013, 8(8): e69230.
17. Wei Wang, Jinyang Cai, Yingliang Wu, Jun Hu, Zongyun Chen, Wenxin Li, Mingxiong Guo*, Zan Huang*. Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB‑containing zinc finger proteins by interacting with KAP1. CMLS-Cellular and Molecular Life Sciences, 2013, 70(20): 3947-3958.
18. Li Hu
#, Wei Wang#, Jinyang Cai, Jun Luo, Yi Huang, Shilu Xiong, Wenxin Li, Mingxiong Guo*. Aberrant expression of ZNF268 alters the growth and migration of ovarian cancer cells. Oncology letters, 2013, 6: 49-54.
19. Wei Wang
#, Mingxiong Guo#, Li Hu, Jinyang Cai, Yan Zeng, Jun Luo, Zhiqiang Shu, Wenxin Li, Zan Huang. The Zinc Finger Protein ZNF268 is Overexpressed in Human Cervical Cancer and Contributes to Tumorigenesis via Enhancing NF-κB Signaling. Journal of Biological Chemistry, 2012, 287(51): 42856-66.

20. Yan Zeng, Wei Wang, Jian Ma, Xianguo Wang, Mingxiong Guo*, Wenxin Li*. Knockdown of ZNF268, Which Is Transcriptionally Downregulated by GATA-1, Promotes Proliferation of K562 Cells. PLoS One, 2012, 7(1): e29518.
21. Hong Yi#, Lu Xue#, Ming-Xiong Guo#, Jian Ma, Yan Zeng, Wei Wang, Jin-Yang Cai, Hai-Ming Hu, Hong-Bing Shu, Yun-Bo Shi, Wen-Xin Li. Gene Expression Atlas for Human Embryogenesis.FASEB Journal, 2010, 24(9): 3341-50.
22. Zhouzhou Zhao, Di Wang, Chengang Zhu, Huanjie Shao, Chong Sun, Hongling Qiu, Lu Xue, Junhua Xu, Mingxiong Guo*, Wenxin Li*. Aberrant alternative splicing of human zinc finger gene ZNF268 in human hematological malignancy. Oncology Reports, 2008, 20(5): 1243-8.
23. Di Wang#, Ming-Xiong Guo#, Zhou-Zhou Zhao, Hong-Ling Qiu, Hai-Ming Hu, Huan-Jie Shao, Chen-Gang Zhu, Lu Xue, Yun-Bo Shi and Wen-Xin Li. Human T-cell leukemiavirus type 1 oncoprotein tax represses ZNF268 expression through the cAMP-responsive Element-binding Protein/Activating Transcription Factor pathway. Journal of Biological Chemistry, 2008, 283(24): 16299-308.
24. Mingxiong Guo, Tao Huang, Yejian Cui, Baiqun Pan, Ao Shen, Yuting Sun, Yourong Yi, Yan Wang, Gengfu Xiao, Guihong Sun. PrPC interacts with tetraspanin-7 through bovine PrP154-182 containing alpha-helix 1. Biochemical and Biophysical Research Communications, 2008, 365(1): 154-7.

25. Ming-Xiong Guo#, Di Wang#, Huan-Jie Shao, Hong-Ling Qiu, Lu Xue, Zhou-Zhou Zhao, Chen-Gang Zhu, Yun-Bo Shi, and Wen-Xin Li. Transcription of Human Zinc Finger ZNF268 Gene Requires an Intragenic Promoter Element. Journal of Biological Chemistry, 2006, 281(34): 24623-36.




职称 副教授 实验室地址 武汉大学生命科学学院4019室
联系电话 13343469985 Email guomx@whu.edu.cn
入选时间 学科专业 细胞生物学
研究方向 肿瘤细胞生物学/微生物生态学

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