严 欢*研究员

学科专业

病毒学

研究方向

病毒受体与入侵机制

实验室位置

生科院5108室

联系电话

Email

huanyan@whu.edu.cn

学习经历

2008.09-2013.06 北京大学/北京生命科学研究所,生物化学与分子生物学 (博士)

2003.09-2008.07 武汉大学医学院,临床医学(学士);武汉大学生命科学学院,生物科学(学士,双学位)


主要工作经历与任职情况

2019.11-至今 武汉大学生命科学学院,病毒学国家重点实验室,研究员

2016.08-2019.09 美国南加州大学医学院分子微生物与免疫学系,博士后

2013.07-2016.08 北京生命科学研究所/默沙东研发(中国),联合博士后


主要社会兼职

2020-今 中国研究型医院学会病毒肿瘤学专业委员会常任委员

2021-今 国际乙肝基金会(HBF)新兴学者科学和医学顾问委员会委员(E-SMAB)


主要科研奖励和个人荣誉

国家奖学金-北京大学,2013

光华奖学金-北京大学,2013

吴瑞奖学金-吴瑞基金会,2013

北大-清华生命科学联合中心CLS博士后奖学金,2015

默沙东中国R&D博士后奖学金-默沙东中国,2013-2016

湖北省人才项目 2020


主持课题项目

2019年 武汉大学自主科研项目 乙肝病毒PreS1多肽中段亚结构域介导病毒入侵的分子机制研究 主持

2020年 国自然面上项目 PreS1与NTCP相互作用在HBV脱包膜过程中的功能与机制研究 主持

2022年 国自然面上项目 ACE2在类MERS冠状病毒中的受体功能与宿主范围决定机制 主持


主要研究领域及兴趣

  本课题组主要关注疾病相关病毒的受体与病毒早期入侵过程,如人类及蝙蝠冠状病毒、乙肝病毒、人乳头瘤病毒等。 我们致力于寻找、设计与优化病毒受体, 建立新型病毒感染模型,阐明病毒入侵、宿主范围决定与跨物种传播的分子机制,并开发新型病毒入侵抑制剂。

代表性成果:

1)曾发现乙肝病毒受体NTCP,并阐明了HBV入侵与种属决定的机制

2)鉴定出NeoCoV, PDF2180等类MERS蝙蝠冠状病毒受体bat ACE2

3)鉴定出HPV候选受体结合肽—L2N多肽

4)揭示了不同种属蝙蝠 ACE2介导冠状病毒入侵能力的显著差异及其分子机制


Our lab is interested in the receptors and entry mechanisms of pathogenic viruses, such as human and bat coronaviruses (CoVs), Hepatitis B viruses (HBV), and Human papillomaviruses (HPV).

We aim to:

Identify, design, and optimize viral receptors for developing novel viral infection models; reveal mechanisms of viral entry, host range determination, and cross-species transmission; develop viral entry inhibitors.

Major achievements:

(1)Identification of HBV receptor NTCP (a well-recognized milestone in the HBV field)

(2)Identification of batACE2 as a functional receptor for MERS-related bat coronaviruses (e.g., NeoCoV and PDF-2180)

(3)Identification of L2 N-terminal peptide as potential receptor binding peptide

(4)Revelation of various susceptibility to SARS-CoV-2 infection across bat species due to different ACE2 fitness


发表的论文(#并列第一作者,*通讯作者)

代表性论文(Selected publications)

成立实验室后 (as PI)

1. Qing Xiong#, Lei Cao#, Chengbao Ma#, M. Alejandra Tortorici#, Chen Liu, Junyu Si, Peng Liu, Mengxue Gu1, Alexandra C. Walls, Chunli Wang, Lulu Shi, Fei Tong, Meiling Huang, Jing Li, Chufeng Zhao, Chao Shen, Yu Chen, Huabin Zhao, Ke Lan, Davide Corti, David Veesler*, Xiangxi Wang*, Huan Yan*. Close relatives of MERS-CoV in bats use ACE2 as their functional receptors. Nature. 2022 Dec; doi:10.1038/s41586-022-05513-3 (Identification of ACE2 as a functional receptor for MERS-related coronaviruses)


2. Huan Yan#, Hengwu Jiao#, Qianyun Liu, Zhen Zhang, Qing Xiong, Bing-Jun Wang, Xin Wang, Ming Guo, Lin-Fa Wang, Ke Lan*, Yu Chen* & Huabin Zhao*. ACE2 receptor usage reveals variation in susceptibility to SARS-CoV and SARS-CoV-2 infection among bat species. Nat. Ecol. & Evol.. 2021 May;5(5):600-608.


3. Qianyun Liu#, Qing Xiong#, Fanghua Mei#, Chengbao Ma, Zhen Zhang, Bing Hu, Junqiang Xu, Yongzhong Jiang, Faxian Zhan, Suhua Zhou, Li Tao, Xianying Chen, Ming Guo, Xin Wang, Yaohui Fang, Shu Shen, Yingle Liu, Fang Liu, Li Zhou, Ke Xu, Changwen Ke, Fei Deng, Kun Cai*, Huan Yan*, Yu Chen*, Ke Lan*. Antibody neutralization to SARS-CoV-2 and variants after one year in Wuhan, China. The Innovation. 2022 Jan 25;3(1):100181.


4. Chengbao Ma#, Xianying Chen#, Fanghua Mei#, Qing Xiong, Qianyun Liu, Lianghui Dong, Chen Liu, Wenjing Zou, Faxian Zhan, Bing Hu, Yingle Liu, Fang Liu, Li Zhou, Junqiang Xu, Yongzhong Jiang, Ke Xu, Kun Cai*, Yu Chen*, Huan Yan*Ke Lan*. Drastic decline in sera neutralization against SARS-CoV-2 Omicron variant in Wuhan COVID-19 convalescents. Emerg. microbes & infect.. 2022 Dec;11(1):567-572.


成立实验室前 (as student)

1. Huan Yan# , Guocai Zhong# , Guangwei Xu, Wenhui He, Zhiyi Jing, Zhenchao Gao, Yi Huang, Yonghe Qi, Bo Peng, Haimin Wang, Liran Fu, Mei Song, Pan Chen, Wenqing Gao, Bijie Ren, Yinyan Sun, Tao Cai, Xiaofeng Feng, Jianhua Sui, Wenhui Li*. Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus. eLife. 2012; 1: e00049. (Identification of HBV receptor NTCP,  which is a well recognized mile stone of the field. 相关研究发现获2020年乙肝研究最高奖Baruch Blumberg奖以及2022年未来科学大奖)


2. Huan Yan, Suan-Sin Foo, Weiqiang Chen, Ji-Seung Yoo, Woo-Jin Shin, Christine Wu, Jae U. Jung*. Efficient inhibition of Human Papillomavirus infection by L2 minor capsid-derived lipopeptide. mBio. 2019 Aug 6;10(4):e01834-19. (Identification of putative HPV receptor binding peptide)


3. Huan Yan#, Bo Peng#, Yang Liu, Guangwei Xu, Wenhui He, Bijie Ren, Zhiyi Jing, Jianhua Sui, Wenhui Li*. Viral Entry of Hepatitis B and D Viruses and Bile Salts Transportation Share Common Molecular Determinants on Sodium Taurocholate Cotransporting Polypeptide. J Virol. 2014 Mar;88(6):3273-84.


4. Huan Yan#, Bo Peng#, Wenhui He, Guocai Zhong, Yonghe Qi, Bijie Ren, Zhenchao Gao, Zhiyi Jing, Mei Song, Guangwei Xu, Jianhua Sui, Wenhui Li*.Molecular determinants of hepatitis B and d virus entry restriction in mouse sodium taurocholate cotransporting polypeptide. J Virol. 2013 Jul;87(14):7977-91.


5. Yang Liu#, Lei Zhang#, Huan Yan#, Zhiqiang Wang, Guoliang Sun, Xiao Song, Zhongmin Zhou, Bo Peng, Liwei Yan, Qingcui Wu, Wenhui Li*, and Xiangbing Qi* Design of Dimeric Bile Acid Derivatives as Potent and Selective Human NTCP Inhibitors. J. Med. Chem. 2021 May 13;64(9):5973-6007.
Specific HBV inhibitors targeting NTCP


6. Shixian Lin#, Huan Yan#, Lin Li, Maiyun Yang, Bo Peng, She Chen, Wenhui Li*, Peng R Chen*. Site-specific Engineering of Chemical Functionalities on the Surface of Live Hepatitis D Virus. Angew. Chem. Int. Ed. 2013 Dec;52(52), 13970-4.


综述

1. Huan Yan, Wenhui Li*. Sodium taurocholate cotransporting polypeptide acts as a receptor for hepatitis B and D virus. Dig Dis. 2015 May; 33(3):388-96.

2. Huan Yan, Yang Liu, Jianhua Sui, Wenhui Li*. NTCP opens the door for hepatitis B virus infection. Antiviral Res. 2015 Sep;121:24-30.


招生招聘

欢迎对病毒学研究感兴趣的本科生、研究生、博士生或博士后加入我们的团队! 有意向加入者请将简历发送至huanyan@whu.edu.cn。

职称 研究员 实验室地址 生科院5108室
联系电话 Email huanyan@whu.edu.cn
入选时间 学科专业 病毒学
研究方向 病毒受体与入侵机制

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