主要从事肿瘤疱疹病毒感染及致瘤机理研究，在卡波氏肉瘤疱疹病毒(KSHV)潜伏感染与致瘤机理研究方面做出了系统性、原创性的研究工作：曾揭示KSHV关键开关分子RTA的表达调控机机理，提出RTA-LANA负反馈调控工作模型，得到领域内的广泛认可，对阐明KSHV潜伏感染的形成机制有重要的指导意义；曾利用KSHV作为工作模型，率先发现病毒包装自身及宿主miRNA，不仅揭示了病毒粒子一种新的构成成分，也鉴定了胞外游离型miRNA的一种新的存在形式，具有重要的学术价值；曾阐明KSHV通过操控Notch及BMP等重要信号转导通路参与致瘤的新机制，为发展相关肿瘤有效的治疗手段奠定了重要基础。
3. Yuan F, Gao ZQ, Majerciak V, Bai L, Hu ML, Lin XX, Zheng ZM*, Dong YH*,Lan K*. The crystal structure of KSHV ORF57 reveals dimeric active sites important for protein stability and function.PLoS Pathog. 2018 Aug 10;14(8):e1007232
4. Yuan F, Gao ZQ, Majerciak V, Bai L, Hu ML, Lin XX, Zheng ZM, Dong YH, Lan K* . The crystal structure of KSHV ORF57 reveals dimeric active sites important for protein stability and function.PLoS Pathog.2018 Aug 10;14(8):e1007232
5. Li G, Zhu Y, Shao D, Chang H, Zhang X, Zhou D, Gao Y,Lan K*, Deng Q*. Recombinant covalently closed circular DNA of hepatitis B virus induces long-term viral persistence with chronic hepatitis in a mouse model.Hepatology. 2018 Jan;67(1):56-70.
6. Wang X, Zou Z, Deng Z, Liang D, Zhou X, Sun R,Lan K*. Male hormones activate EphA2 to facilitate Kaposi's sarcoma-associated herpesvirus infection: Implications for gender disparity in Kaposi's sarcoma.PLoS Pathog. 2017 Sep 28;13(9):e1006580.
7. Zou Z, Meng Z, Ma C, Liang D, Sun R,Lan K*. Guanylate-binding protein 1 inhibits nuclear delivery of Kaposi's sarcoma-associated herpesvirus virions by disrupting formation of actin filament.J Virol.2017 Jul 27;91(16). pii: e00632-17
8. Lin X, Sun R, Zhang F, Gao Y, Bin L,Lan K*. The Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus Inhibits Expression of SUMO/sentrin Specific Peptidase 6 to Facilitate Latency Establishment.J Virol.2017 Aug 10;91(17). pii: e00806-17
9. Sun R, Tan X, Wang X, Wang X, Yang L, Robertson ES,Lan K*. Epigenetic Landscape of Kaposi's Sarcoma-Associated Herpesvirus Genome in Classic Kaposi's Sarcoma Tissues.PLoS Pathog.2017 Jan 24;13(1):e1006167
10. Li S, Hu H, He Z, Liang D, Sun R,Lan K*. Fine-Tuning of the Kaposi's Sarcoma-Associated Herpesvirus Life Cycle in Neighboring Cells through the RTA-JAG1-Notch Pathway.PLoS Pathog.2016 Oct 19;12(10):e1005900
11. Hu H, Dong J, Liang D, Gao Z, Bai L, Sun R, Hu H, Zhang H, Dong Y,Lan K*. Genome-wide mapping of the binding sites and structural analysis of KSHV vIRF2 reveal it is a DNA-binding transcription factor.J Virol.2015 Nov 4;90(3):1158-68
12. Jia B, Guo M, Li G, Yu D, Zhang X,Lan K*, Deng Q*. Hepatitis B virus core protein sensitizes hepatocytes to tumor necrosis factor-induced apoptosis by suppression of the phosphorylation of mitogen-activated protein kinase kinase 7.J Virol. 2015 Feb 15;89(4):2041-51.
16. Qi Z, Li G, Hu H, Yang C, Zhang X, Leng Q, Xie Y, Yu D, Zhang X, Gao Y,Lan K*, Deng Q*. Recombinant Covalently Closed Circular Hepatitis B Virus DNA Induces Prolonged Viral Persistence in Immunocompetent Mice.J Virol. 2014 Jul;88(14):8045-56
17. Sun R, Liang D, Gao Y,Lan K*. Kaposi's Sarcoma-Associated Herpesvirus-Encoded LANA Interacts with Host KAP1 To Facilitate Establishment of Viral Latency.J Virol. 2014 Jul 1;88(13):7331-7344.
18. Han J, Wang L, Liu J, Jin M, Hao F, Zhang P, Zhang Z, Wen D, Wu X, Liu G, Ji L, Xu D, Zhou D, Leng Q,Lan K*, Zhang C*. Co-circulation of three HA and two NA subtypes of avian influenza viruses in Huzhou, China, April 2013: implication for the origin of the novel H7N9 virus.J Virol. 2014 Jun;88(11):6506-11
19. Wang X, He Z, Xia T, Li X, Liang D, Lin X, Wen H,Lan K*. Latency-Associated Nuclear Antigen of Kaposi Sarcoma-Associated Herpesvirus Promotes Angiogenesis through Targeting Notch Signaling Effector Hey1.Cancer Res. 2014 Apr 1;74(7):2026-37.
20. Wang Z, Zhu K, Bai W, Jia B, Hu H, Zhou D, Zhang X, Zhang X, Xie Y, Bourgine MM, Michel ML,Lan K*, Deng Q*. Adenoviral delivery of recombinant hepatitis B virus expressing foreign antigenic epitopes for immunotherapy of persistent viral infection.J Virol. 2014 Mar;88(5):3004-15.
21. Han J, Jin M, Zhang P, Liu J, Wang L, Wen D, Wu X, Liu G, Zou Y, Lv X, Dong X, Shao B, Gu S, Zhou D, Leng Q, Zhang C,Lan K. Epidemiological link between exposure to poultry and all influenza A(H7N9) confirmed cases in Huzhou city, China, March to May 2013.Euro Surveill. 2013 May 16;18(20). pii: 20481.
22. Han J, Niu F, Jin M, Wang L, Liu J, Zhang P, Xie B, Wu X, Wen D, Ji L, Liu G, Yang Z, Zhang C, Zhou D, Leng Q,Lan K*. Clinical presentation and sequence analyses of HA and NA antigens of the novel H7N9 viruses.Emerg Microbes Infect.2013 May;2(5):e23.
23. Xia T, L évy L, Levillayer F, Jia B, Li G, Neuveut C, Buendia MA,Lan K*, Wei Y*.The Four and a Half LIM-only Protein 2 (FHL2) Activates Transforming Growth Factorβ(TGF-β) Signaling by Regulating Ubiquitination of the E3 Ligase Arkadia.J Biol Chem. 2013 Jan 18;288(3):1785-94.
24. Yang Y, Xia T, Li N, Zhang J, Yang Y, Cong W, Deng Q,Lan K*, Zhou W*. Combined effects of p53 and MDM2 polymorphisms on susceptibility and surgical prognosis in hepatitis B virus-related hepatocellular carcinoma.Protein Cell. 2013 Jan;4(1):71-81.
25. Lin X, Li X, Liang D,Lan K*. MicroRNAs and unusual small RNAs discovered in Kaposi's sarcoma-associated herpesvirusvirions.J Virol. 2012 Dec; 86(23): 12717-30.
26. Jin Y, He Z, Liang D, Zhang Q, Zhang H, Deng Q, Robertson ES,Lan K*. Carboxyl-Terminal Amino Acids 1052 to 1082 of the Latency-Associated Nuclear Antigen (LANA) Interact with RBP-J κand Are Responsible for LANA-Mediated RTA Repression.J Virol. 2012 May;86(9):4956-69
27. Liang D, Lin X,Lan K*. Looking at Kaposi's Sarcoma-Associated Herpesvirus-Host Interactions from a microRNA Viewpoint.Front Microbiol. 2011;2:271.
28. Liu Y, Sun R, Lin X, Liang D, Deng Q,Lan K*. Kaposi's sarcoma-associated herpesvirus-encoded microRNA miR-K12-11 attenuates transforming growth factor beta signaling through suppression of SMAD5.J Virol. 2012 Feb; 86(3):1372-81.
29. Li X, Liang D, Lin X, Robertson ES,Lan K*. Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen reduces interleukin-8 expression in endothelial cells and impairs neutrophil chemotaxis by degrading nuclear p65.J Virol. 2011 Sep;85(17):8606-15.
30. Qin Y, Li Y, Liu W, Tian R, Guo Q, Li S, Li H, Zhang D, Zheng Y, Wu L,Lan K*,Wang J*. Penicilliummarneffei-stimulated dendritic cells enhance HIV-1 trans-infection and promote viral infection by activating primary CD4+ T cells.PLoS One. 2011;6(11):e27609
31. Lin X, Liang D, He Z, Deng Q, Robertson ES,Lan K*. miR-K12-7-5p encoded by Kaposi's sarcoma-associated herpesvirus stabilizes the latent state by targeting viral ORF50/RTA.PLoS One. 2011 Jan 20;6(1):e16224.
32. Liang D, Gao Y, Lin X, He Z, Zhao Q, Deng Q,Lan K*. A human herpesvirusmiRNA attenuates interferon signaling and contributes to maintenance of viral latency by targeting IKK ε.Cell Res. 2011 May;21(5):793-806.
33. Wang X, He B, Zhang Z, Liu T, Wang H, Li X, Zhang Q,Lan K, Lu X, Wen H*. Human herpesvirus-8 in northwestern China: epidemiology and characterization among blood donors.Virol J. 2010 Mar 17;7:62.
34. He Z, Liu Y, Liang D, Wang Z, Robertson ES,Lan K*. Cellular corepressor TLE2 inhibits replication-and-transcription- activator-mediated transactivation and lytic reactivation of Kaposi's sarcoma-associated herpesvirus.J Virol. 2010 Feb;84(4):2047-62.
35. Lan K , Murakami M, Bajaj B, Kaul R, He Z, Gan R, Feldman M, Robertson ES. Inhibition of KSHV-infected primary effusion lymphomas in NOD/SCID mice by gamma-secretase inhibitor.Cancer Biol Ther. 2009 Nov;8(22):2136-43.
36. Liu Y, Cao Y, Liang D, Gao Y, Xia T, Robertson ES,Lan K*. Kaposi's sarcoma-associated herpesvirus RTA activates the processivity factor ORF59 through interaction with RBP-Jkappa and a cis-acting RTA responsive element.Virology. 2008 Oct 25;380(2):264-75.
37. Lan K , Verma SC, Murakami M, Bajaj B, Kaul R, Robertson ES. Kaposi's sarcoma herpesvirus-encoded latency-associated nuclear antigen stabilizes intracellular activated Notch by targeting the Sel10 protein.Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16287-92.
38. Lan K , Murakami M, Choudhuri T, Tsai DE, Schuster SJ, Wasik MA, and Robertson E. Detection of Epstein-Barr Virus in T-Cell Prolymphocytic Leukemia cells in vitro.J Clin Virol.2008;43:260-5.
39. Verma S,Lan K, Choudhuri T, Cotter MA, and Robertson E. An autonomous replicating element within the KSHV genome.Cell Host Microbe.2007 Aug 16;2(2):106-18.
40. Lan K , Choudhuri T, Murakami M, Kuppers DA, and Robertson E. Intracellular Activated Notch1 Is Critical for Proliferation of KSHV Associated B Lymphoma Cell Lines in vitro.J Virol. 2006, 80(13):6411-6419
41. Lan K , Murakami M, Choudhuri T, Kuppers D, and Robertson E. Intracellular Activated Notch1 Can Reactivate KSHV from Latency.Virology. 2006, 351:393-403.
42. Lan K , Kuppers D, Verma S, Sharma N, Murakami M, and Robertson E. Induction of KSHV Latency Associated Nuclear Antigen by the Lytic Transactivator RTA: A Novel Mechanism for Establishment of Latency.J Virol. 2005;79(12):7453-65
43. Lan K , Kuppers D, and Robertson E. KSHV Reactivation is Regulated by Interaction of LANA with RBP-Jk, the Major Downstream Effector of the Notch Signaling Pathway.J Virol.2005;79(6):3468-78
44. Lan K , Kuppers DA, Verma SC, and Robertson E. Kaposi ’s Sarcoma-Associated Herpesvirus-Encoded Latency-Associated Nuclear Antigen Inhibits Lytic Replication by Targeting Rta: a Potential Mechanism for Virus-Mediated Control of Latency.J Virol. 2004;78: 6585-6594
