姚 镜教授

学科专业

细胞生物学、生理学、神经生物物理学

研究方向

离子通道在生理与病理状态下的调控及干预

实验室位置

生命科学学院大楼2105室

联系电话

+86-27-68752148

Email

jyao@whu.edu.cn

学习经历

2006/09-2009/07,美国纽约州立布法罗大学生理与生物物理系,联合培养博士生

2006/09-2009/07,华中科技大学生命科学与技术学院生物物理专业,博士

2002/09-2005/07,华中科技大学生命科学与技术学院生物物理专业,硕士

1996/09-2000/07,华中科技大学生命科学与技术学院生物技术专业,本科


主要工作经历与任职情况

2012/12-至今,武汉大学,生命科学学院,病毒学国家重点实验室,教授

2011/10,湖北省高层次人才项目入选者

2011/02-2012/12,华中科技大学,生命科学与技术学院,分子生物物理教育部重点实验室,教授

2005/10-2011/01,美国纽约州立布法罗大学,生理与生物物理系,先后担任研究助理与博士后


主要学术兼职

Ÿ中国神经科学学会 “离子通道与受体专业委员会” 副秘书长

Ÿ中国生物物理学会“膜生物学专业委员会” 理事

Ÿ中国生物物理学会“神经生物物理专业委员会” 理事

Ÿ中国药理学会“神经精神药理专业委员会” 青年委员

Ÿ中国康复医学会“科技管理与评估委员会”常务委员

Ÿ湖北省细胞生物学会 理事

Ÿ湖北省生物物理学会 理事


主要研究领域及兴趣

离子通道作为机体感知周围环境信息的功能界面,是生物体与内部和外部环境交流不可或缺的信号途径,在感受到内、外界刺激信息后,作为感受器的离子通道能够将这些刺激信息转换成神经电信号,并将这一信号传递到大脑或神经系统的其它部位,神经系统进而对这些刺激信号作出反应。课题组主要聚焦一类和温度感受相关的瞬时受体势(transient receptor potential vanilloid, TRPV)通道开展研究,这些通道广泛分布于神经和非神经组织中,通过介导种类多样的理化刺激响应,在体感信息传递和中枢信息处理等核心生理过程中发挥重要功能。我们在深入解析这些离子通道的门控(开启或关闭)机制,并阐释它们在环境感知与应激中的作用的基础上,进而揭示了其在生理病理过程中的关键作用。同时,通过发现靶向离子通道的药物,从而为实现机体的稳态平衡提供新策略。


教学情况

本科生课程:“神经生物学”(2学分)和“专业文献研读”(2学分)

研究生课程:“细胞生物学研究方法”(2学分)


主持课题项目

主持或参加有国家自然科学基金委面上项目、重点项目、海外及港澳合作项目,湖北省自然科学基金重点项目,和湖北省自然科学基金杰出青年项目。


论文列表(#Co-first author; * Corresponding author

(1)Quan Tian#, Peiyu Wang#, Chang Xie#, Peiyuan Pang, Youjing Zhang, Yue Gao, Zhijian Cao, Yingliang Wu, Wenxin Li, Michael X. Zhu, Dongdong Li,Jing Yao*.Identification of an arthropod molecular target for plant-derived natural repellents.Proc. Natl. Aca. Sci. USA.2022, May 3;119(18): e2118152119. doi: 10.1073/pnas.2118152119.

(2)XiaoyiMo#, Peiyuan Pang#, Yulin Wang, Dexiang Jiang, Mengyu Zhang, Yang Li, Peiyu Wang, Qizhi Geng, Chang Xie, Hai-Ning Du, Bo Zhong, Dongdong Li,Jing Yao*. Tyrosine phosphorylation tunes chemical and thermal sensitivity of TRPV2 ion channel.eLife. 2022 Jun 10; 11: e78301. doi: 10.7554/eLife.78301. Online ahead of print.

(3)Peiyu Wang, Xiaoyi Mo, Dongdong Li,Jing Yao*. Dyclonine inhibition of TRPV3: From functional discovery to structural insight.Cell Calcium. 2022 Jun 22; 105:102617. doi: 10.1016/j.ceca.2022.102617. Online ahead of print. (Invited commentary)

(4)Xiaoyi Mo#, Qiang Liu#, Luna Gao#, Chang Xie#, Xin Wei, Peiyuan Pang, Quan Tian, Yue Gao, Youjing Zhang, Yuanyuan Wang, Tianchen Xiong, Bo Zhong, Dongdong Li,Jing Yao*.The industrial solvent1,4-Dioxanecauses hyperalgesiabytargeting capsaicin receptor TRPV1.BMC Biol.2022 Jan 7; 20(1):10. doi: 10.1186/s12915-021-01211-0.2021.

(5)Qiang Liu#, Jin Wang#, Xin Wei, Juan Hu, Conghui Ping, Yue Gao, Chang Xie, Peiyu Wang, Peng Cao, Zhengyu Cao, Ye Yu, Dongdong Li,Jing Yao*. Therapeutic inhibition of keratinocyte TRPV3 sensory channel by local anesthetic dyclonine.eLife. 2021 Apr 20; 10: e68128. doi: 10.7554/eLife.68128.(Recommended by Faculty of 1000)

(6)Juan Hu#, Yue Gao#, Qian Huang#, Yuanyuan Wang, Xiaoyi Mo, Peiyu Wang, Youjing Zhang, Chang Xie, Dongdong Li,Jing Yao*. Flotillin-1 interacts with and sustains the surface levels of TRPV2 channel.Front. Cell Dev. Biol.2021 Feb 09; 9:634160. doi: 10.3389/fcell.2021.634160

(7)Yange Lang#, Fangfang Li#, Qiang Liu#, Zhiqiang Xia#, Zhenglin Ji, Juan Hu, Yuting Cheng, Minjun Gao, Fang Sun, Bingzheng Shen, Chang Xie, Wei Yi, Yingliang Wu,Jing Yao*, Zhijian Cao*. The Kv1.3 ion channel acts as a host factor restricting viral entry.FASEB J.2021 Feb;35(2): e20995. doi: 10.1096/fj.202000879RR. Epub 2020 Sep 10.

(8)Bingjie Yang#, Quan Tian, Xin Wei, Hao Zhang,Jing Yao*. Research progress on post-translational modification regulate the function of TRPV channels.Progress in Biochemistry and Biophysics, 2021,48(2): 171-183. (Review in Chinese)

(9)Yuanyuan Wang#, Xiaoyi Mo#, Conghui Ping, Qian Huang, Hao Zhang, Chang Xie, Bo Zhong, Dongdong Li,Jing Yao*. Site-specific contacts enable distinct modes of TRPV1 regulation by the potassium channel Kvβ1subunit.J.Biol.Chem.2020 Dec 11; 295(50):17337-17348. doi: 10.1074/jbc.RA120.015605.

(10)Jiaoli Sun#, Lulu Li#, Luyao Yang, Guangyou Duan , Tingbin Ma, Ningbo Li, Yi Liu,Jing Yao, Jing Yu Liu*, Xianwei Zhang*. Novel SCN9A missense mutations contribute to congenital insensitivity to pain: Unexpected correlation between electrophysiological characterization and clinical phenotype.Mol Pain. 2020 Apr 2; 16:1-9. doi: 10.1177/1744806920923881.

(11)Quan Tian#, Juan Hu#, Chang Xie#, Kaidi Mei, Cuong Pham, Xiaoyi Mo, Régine Hepp, Sylvia Soares, Fatiha Nothias, Yuanyuan Wang, Qiang Liu, Fen Cai, Bo Zhong, Dongdong Li*,Jing Yao*. Recovery from tachyphylaxis of TRPV1 coincides with recycling to the surface membrane.Proc. Natl. Aca. Sci. USA.2019 Mar 12; 116(11):5170-5175. doi: 10.1073/pnas.1819635116.

(12)Tingting Zhang,Jing Yao*. Research advances in the functional roles of ion channels in immune cell and immune response.Acta Physiologica Sinica, December 25, 2019, 71(6):894-904. DOI: 10.13294/j.aps.2019.0074 (Cover story, review in Chinese)

(13)Yiming Yang#, Mengnan Xu, Xiaojuan Zhu,Jing Yao, Bing Shen, Xian-PingDong*. Lysosomal Ca2+release channel TRPML1 regulates lysosome size by promoting mTORC1 activity.Eur J Cell Biol.2019 Jun; 98(2-4):116-123. doi: 10.1016/j.ejcb.2019.05.001.

(14)Yan Wang#, Yingwei Gao#, Quan Tian#, Qi Deng, Yangbo Wang, Tian Zhou, Qiang Liu, Kaidi Mei, Yingping Wang, Huiqing Liu, Ruining Ma, Yuqiang Ding, Weifang Rong, Jinke Cheng,Jing Yao*, Tian-Le Xu, Michael X. Zhu, and Yong Li*.TRPV1 SUMOylation regulates nociceptive signaling in models of inflammatory pain.Nat. Commun., 2018;9(1):1529.(Recommended by Faculty of 1000)

(15)He Sun#, Qiang Zhang#, Ying-Ying Jing, Man Zhang, Hai-Ying Wang, Zeng Cai, Tianzi Liuyu, Zhi-Dong Zhang, Tian–Chen Xiong, Yan Wu, Qi-Yun Zhu,Jing Yao, Hong-Bing Shu, Dandan Lin & Bo Zhong*. USP13 negatively regulates antiviral responses by deubquitinating STING.Nat. Commun., 2017, 8:15534.

(16)Man Zhang#, Meng-Xin Zhang#, Qiang Zhang, Gao-Feng Zhu, Lei Yuan, Dong-Er Zhang, Qiyun Zhu,Jing Yao, Hong-Bing Shu and Bo Zhong*.USP18 recruits USP20 to promote innate antiviral response through deubiquitinating STING/MITA.Cell Res.2016 Dec;26(12):1302-1319.

(17)Yao Xiao, Maomao Gao, Luna Gao, Yu Zhao, Qiang Hong, Zhigang Li,Jing Yao, Hanhua Cheng*, and Rongjia Zhou*.Directed Differentiation of Zebrafish Pluripotent Embryonic Cells to Functional Cardiomyocytes.Stem Cell Reports.2016 Aug 23. pii: S2213-6711(16)30144-8. doi: 10.1016/j.stemcr.2016.07.020.

(18)Yujie Ren, Yin Zhao, Dandan Lin, Ximing Xu, Qiyun Zhu,Jing Yao, Hong-Bing Shu and Bo Zhong*.The type I interferon-IRF7 axis mediates transcriptional expression of Usp25.J.Biol.Chem.2016 Jun 17;291(25):13206-15. doi: 10.1074/jbc.M116.718080.

(19)Chuangeng Zhang#, Zili Xie#, Xinxin Li, Jing Chen, Jing Feng, Yange Lang, Weishan Yang, Wenxin Li, Zongyun Chen,Jing Yao, Zhijian Cao*and Yingliang Wu*.Molecular basis for the toxin insensitivity of scorpion voltage-gated potassium channel MmKv1.Biochem. J.,2016 May 1;473(9):1257-66. doi: 10.1042/BCJ20160178.

(20)Luna Gao#, Pu Yang#, Peizhong Qin#, Yungang Lu, Xinxin Li, Quan Tian, Yang Li,Chang Xie, Jin-Bin Tian, Chengwei Zhang, Changlin Tian, Michael X. Zhu*,Jing Yao*.Selective potentiation of 2-APB-induced activation of TRPV1-3 channels by acid.Sci. Rep.2016 Feb; 6, 20791; doi: 10.1038/srep20791.

(21)Chang Xie#, Haowen Liu#, Na Pan, Jiuping Ding andJing Yao*. The residue I257 at S4-S5 linker in KCNQ1 determines KCNQ1/KCNE1 channel sensitivity to 1-alkanols.Acta Pharmacol. Sin.2016 Jan; 37(1):124-33.

(22)Xiang Yang Zhang#, Jingmin Wen#, Wei Yang#, Cheng Wang, Luna Gao, Liang Hong Zheng, Tao Wang, Kaikai Ran, Yulei Li, Xiangyang Li, Ming Xu, Junyu Luo, Shenglei Feng, Xixiang Ma, Hongying Ma, Zuying Chai, Zhuan Zhou,Jing Yao*, Xue Zhang, Jing Yu Liu*.Gain-of-Function Mutations inSCN11ACause Familial Episodic Pain.Am. J. Hum. Genet., 2013 Nov. 7; 93(5):957-66.

(23)Lu Zeng, Wenqiang Liu, Wenguo Feng, Xing Wang, Hui Dang, Luna Gao,Jing Yaoand Xianqin Zhang*.A novel donor splice-site mutation of major intrinsic protein gene associated with congenital cataract in a Chinese family.Mol Vis.2013 Nov 14; 19:2244-9.

(24)YingWu#, Yongfeng Liu#, Panpan Hou#, Zonghe Yan, Wenjuan Kong, Beiying Liu , Xia Li,Jing Yao, Yuexuan Zhang, Feng Qin*, Jiuping Ding*. TRPV1 Channels Are Functionally Coupled with BK(mSlo1) Channels in Rat Dorsal Root Ganglion (DRG) Neurons.PLoS One. 2013 Oct 16; 8(10): e78203. doi: 10.1371/journal.pone.0078203.

(25)Panpan Hou#, Wenping Zeng#, Geliang Gan#, Caixia Lv#, Xiying Guo, Zheng Zhang, Haowen Liu, Ying Wu,Jing Yao, Aguan D., Wei, Sheng Wang*and Jiuping Ding*.Inter-α/β subunits coupling mediating pre-inactivation and augmented activation of BKCa(β2).Sci Rep.2013 Apr 16;3:1666.P1-8.doi: 10.1038/srep01666.

(26)Lisi Wei#, Su Chen#, Xianju Huang,Jing Yaoand Xiangming Liu*.Material basis for inhibition of dragon’s blood on capsaicin-induced TRPV1 receptor currents in rat dorsal root ganglion neurons.Eur J Pharmacol.2013 Feb 28;702(1-3):275-84. doi: 10.1016/j.ejphar.2013.01.052.

(27)Wei Wang#, Feng Xiao#, Xuhui Zeng,Jing Yao, Ming Yuchi*and Jiuping Ding*.Optimal Estimation of Ion-channel Kinetics from Macroscopic Currents.Plos One.2012Mar;7(4): e35208.

(28)Cheng Wang#, Yulei Li#, Lei Shi#, Jie Ren, Monica Patti, Tao Wang, João R M de Oliveira, María-Jesús Sobrido, Beatriz Quintáns, Miguel Baquero, Xiaoniu Cui, Xiang-Yang Zhang, Lianqing Wang, Haibo Xu, Junhan Wang,Jing Yao, Xiaohua Dai, Juan Liu, Lu Zhang, Hongying Ma, Yong Gao, Xixiang Ma, Shenglei Feng, Mugen Liu, Qing K Wang, Ian C Forster, Xue Zhang*& Jing-Yu Liu*.Mutations inSLC20A2link familial idiopathic basal ganglia calcification with phosphate homeostasis.Nat Genet.2012 Feb 12. 44(3):254-6. doi: 10.1038/ng.1077.

(29)Beiying Liu#,Jing Yao#and Feng Qin*.Hysteresis of Gating Underlines Sensitization of TRPV3 Channels.J Gen Physiol.2011Nov;138(5):509-20.(#Co-first author, Recommended by Faculty of 1000)

(30)Jing Yao#,Beiying Liu#and Feng Qin*. Modular thermal sensors in temperature-gated transient receptor potential (TRP) channels.Proc. Natl. Aca. Sci. USA.2011 Jul 5;108(27):11109-14.

(31)Jing Yao#,Beiying Liuand Feng Qin*. Pore turret of thermal TRP channels is not essential for temperature sensing.Proc. Natl. Aca. Sci. USA.2010,Aug10;107(32): E125.

(32)Jing Yao#, Beiying Liu#and Feng Qin*.Kinetics and Energetic Analysis of Thermally Activated TRPV1 channels.Biophys. J. 2010Sep 22;99(6):1743-53.

(33)Beiying Liu#,Jing Yao#,Yingwei Wang#, Hui Li and Feng Qin*.Proton inhibition ofUnitary Currents of Vanilloid Receptors.J Gen Physiol.2009Aug31;134(3):243-58. (#Co-first author)

(34)Jing Yao#, Beiying Liu#and Feng Qin*.Rapid temperature jump by infrared diode laser irradiation for patch-clamp studies.Biophys. J. 2009May6;96(9):3611-9.

(35)Jing Yaoand Feng Qin*. Interaction with phosphoinositides confers adaptation of pain receptors TRPV1.PLos. Biol.2009Feb.24, 7 (2): e46.

(36)Sujung Ryu#, Beiying Liu#,Jing Yao#, Qiang Fu#ang Feng Qin*. Uncoupling proton activation of vanilloid receptor TRPV1.J Neurosci. 2007 Nov 21,27(47): 12797-807.

(37)Xiaotian Tong#,Jing Yao#, Feng He, Xiang Chen, X. Zheng, Chang Xie, Gong Wu, Naixia Zhang, Jiuping Ding and Houming Wu*. NMR solution structure of BmK-betaIT, an excitatory scorpion beta-toxin without a 'hot spot' at the relevant position.Biochem Biophys Res Commun. 2006 Oct 27; 349(3): 890-9.

(38)Hui Li#,Jing Yao#, Xiaotian Tong, Zhaohua Guo, Ying Wu, Liang Sun, Na Pan, Houming Wu, Tao Xu*, and Jiuping Ding*. Interaction sites between theSlo1pore and the NH2terminus of the β2 subunit, probed with a three-residue sensor.J Biol Chem, 2007, 282(24): 17720-8.

(39)Jing Yao#, Hui Li#, Geliang Gan, Ying Wu, and Jiuping Ding*.Residue Phe266 in S5-S6 loop is not critical for Charybdotoxin binding to Ca2+-activated K+(mSlo1) channels.Acta Pharmacologica Sinica, 2006, 27: 945-9.

(40)Jing Yao#, Xiang Chen#, Hui Li, Yang Zhou, Lijun Yao, Gong Wu, Xiaoke Chen, Naixia Zhang, Zhuan Zhou, Tao Xu, Houming Wu*, and Jiuping Ding*. BmP09, a “Long Chain” scorpion peptide blocker of BK channels.J Biol Chem, 2005,280: 14819-28.

职称 教授 实验室地址 生命科学学院大楼2105室
联系电话 +86-27-68752148 Email jyao@whu.edu.cn
入选时间 学科专业 细胞生物学、生理学、神经生物物理学
研究方向 离子通道在生理与病理状态下的调控及干预

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