学习经历

1992-1997年 原湖北医科大学 临床医疗专业 学士

1997-2000年 武汉大学医学院 组织胚胎学专业 硕士

2002-2006年 日本福岛医科大学 免疫学 博士

主要工作经历与任职情况

1997年-2002年 武汉大学医学院组织胚胎学教研室 助教、讲师

2006年-至今 武汉大学生命科学学院 副教授、教授、博士生导师

主要研究领域及兴趣

1. 抗病毒天然免疫应答的信号转导调控

2. 炎症相关信号转导调控

主要研究抗感染天然免疫的干扰素效应及炎症反应的信号转导调控机制，在分子、细胞和动物水平，探索抗感染天然免疫信号通路的异常与炎症性疾病、自身免疫性疾病之间的关联，为病毒性传染病、炎症性疾病及自身免疫性疾病的防治提供分子靶标。

承担课程（本科生、研究生）

本科生：

1. 基础通识课《自然科学经典导引》

2. 专业选修课《病原生物学》

研究生：

《细胞信号转导》

主持课题项目

主持国家自然基金面上项目7项；主持973项目及重点研发计划项目的子课题

代表性论文：

1. Zhang, J., Zhou, E. C., He, Y., Chai, Z. L., Ji, B. Z., Tu, Y., Wang, H. L., Wu, W. Q., Liu, Y., Zhang, X. H., and Liu, Y*. (2023) ZYG11B potentiates the antiviral innate immune response by enhancing cGAS-DNA binding and condensation. Cell Rep 42, 112278
2. Tu, Y., Yin, X. J., Liu, Q., Zhang, S., Wang, J., Ji, B. Z., Zhang, J., Sun, M. S., Yang, Y., Wang, C. H., Yin, L., and Liu, Y*. (2022) MITA oligomerization upon viral infection is dependent on its N-glycosylation mediated by DDOST. PLoS Pathog 18, e1010989
3. Yang, Y., Hu, Y. H., and Liu, Y*. (2020) Wdfy1 deficiency impairs Tlr3-mediated immune responses in vivo. Cell Mol Immunol 17, 1014-1016
4. Ning, F., Li, X., Yu, L., Zhang, B., Zhao, Y., Liu, Y., Zhao, B., Shang, Y., and Hu, X. (2019) Hes1 attenuates type I IFN responses via VEGF-C and WDFY1. J Exp Med 216, 1396-1410
5. Sun, M. S., Zhang, J., Jiang, L. Q., Pan, Y. X., Tan, J. Y., Yu, F., Guo, L., Yin, L., Shen, C., Shu, H. B., and Liu, Y*. (2018) TMED2 Potentiates Cellular IFN Responses to DNA Viruses by Reinforcing MITA Dimerization and Facilitating Its Trafficking. Cell Rep 25, 3086-3098 e3083
6. Jiang, L. Q., Xia, T., Hu, Y. H., Sun, M. S., Yan, S., Lei, C. Q., Shu, H. B., Guo, J. H., and Liu, Y*. (2018) IFITM3 inhibits virus-triggered induction of type I interferon by mediating autophagosome-dependent degradation of IRF3. Cell Mol Immunol 15, 858-867
7. Jia, R., Zhang, S., Liu, M., Zhang, Y., Liu, Y., Fan, M., and Guo, J. (2016) HnRNP L is important for the expression of oncogene SRSF3 and oncogenic potential of oral squamous cell carcinoma cells. Sci Rep 6, 35976
8. Chen, L. T., Hu, M. M., Xu, Z. S., Liu, Y., and Shu, H. B. (2016) MSX1 Modulates RLR-Mediated Innate Antiviral Signaling by Facilitating Assembly of TBK1-Associated Complexes. J Immunol 197, 199-207
9. Hu, Y. H., Zhang, Y., Jiang, L. Q., Wang, S., Lei, C. Q., Sun, M. S., Shu, H. B., and Liu, Y*. (2015) WDFY1 mediates TLR3/4 signaling by recruiting TRIF. EMBO Rep 16, 447-455
10. Wang, S., Li, Y., Hu, Y. H., Song, R., Gao, Y., Liu, H. Y., Shu, H. B., and Liu, Y*. (2013) STUB1 is essential for T-cell activation by ubiquitinating CARMA1. Eur J Immunol 43, 1034-1041
11. Li, Y., He, X., Wang, S., Shu, H. B., and Liu, Y*. (2013) USP2a positively regulates TCR-induced NF-kappaB activation by bridging MALT1-TRAF6. Protein Cell 4, 62-70
12. He, X., Li, Y., Li, C., Liu, L. J., Zhang, X. D., Liu, Y*, and Shu, H. B*. (2013) USP2a negatively regulates IL-1beta- and virus-induced NF-kappaB activation by deubiquitinating TRAF6. J Mol Cell Biol 5, 39-47
13. Li, C., Wei, J., Li, Y., He, X., Zhou, Q., Yan, J., Zhang, J., Liu, Y., Liu, Y., and Shu, H. B. (2013) Transmembrane Protein 214 (TMEM214) mediates endoplasmic reticulum stress-induced caspase 4 enzyme activation and apoptosis. J Biol Chem 288, 17908-17917
14. Liu, Y*, Song, R., Gao, Y., Li, Y., Wang, S., Liu, H. Y., Wang, Y., Hu, Y. H., and Shu, H. B. (2012) Protein kinase C-delta negatively regulates T cell receptor-induced NF-kappaB activation by inhibiting the assembly of CARMA1 signalosome. J Biol Chem 287, 20081-20087
15. Li C, Zhang WP, Li Y, Guo L, Shu HB, and Liu Y* (2012). ISG60 Negatively Regulates Cell Antiviral Responses by Disrupting the VISA-Associated Complexes. Wuhan Uni J Natl Sci 17(1): 1-6.
16. Endo, Y., Takahashi, M., Iwaki, D., Ishida, Y., Nakazawa, N., Kodama, T., Matsuzaka, T., Kanno, K., Liu, Y., Tsuchiya, K., Kawamura, I., Ikawa, M., Waguri, S., Wada, I., Matsushita, M., Schwaeble, W. J., and Fujita, T. (2012) Mice deficient in ficolin, a lectin complement pathway recognition molecule, are susceptible to Streptococcus pneumoniae infection. J Immunol 189, 5860-5866
17. Chen, R., Zhang, L., Zhong, B., Tan, B., Liu, Y., and Shu, H. B. (2010) The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling. Cell Res 20, 802-811
18. Liu Y, Endo Y, Iwaki D, Nakata M, Matsushita M, Wada I, Inoue K, Munakata M, and Fujita T*. (2005) Human M-ficolin is a secretory protein that activates the lectin complement pathway. J Immunol 175(5): 3150-3156
19. Liu Y, Endo Y*, Homma S, Kanno K, Yaginuma H, and Fujita T. (2005) Ficolin A and ficolin B are expressed in distinct ontogenic patterns and cell types in the mouse.  Mol Immunol 42(11): 1265-1273
20. Liu Y, Song J*, Liu W, Wan Y, Chen X, Hu C. (2003). Growth and differentiation of rat bone marrow stromal cells: does 5-azacytidine trigger their cardiomyogenic differentiation?  Cardiovas Res 58(2): 460-468