郭明雄教授

学科专业

细胞生物学

研究方向

肿瘤细胞生物学/微生物生态学

实验室位置

武汉大学生命科学学院4019室

联系电话

13343469985

Email

guomx@whu.edu.cn

学习经历

2003.09 – 2006.12 武汉大学生命科学学院微生物专业, 博士

2000.09 – 2003.06 武汉大学生命科学学院生物物理专业, 硕士

1990.09 – 1994.06 武汉大学生命科学学院微生物专业, 学士


主要工作经历与任职情况

1. 2022.11 - 至今,武汉大学生命科学学院,教授

2. 2020.08 - 2023.12,西藏大学理学院 / 生态环境学院(援藏),副院长,副教授 / 教授

3. 2009.11 - 2022.11,武汉大学生命科学学院,副教授

4. 2012.01 - 2012.12,美国纽约州奥尔巴尼医学院,访问学者

5. 2007.02 - 2009.11,武汉大学生命科学学院,讲师

6. 1994.07 - 2000.08,湖北中医药大学基础医学院(原湖北中医学院基础部),助教


主要社会兼职

1. 中国细胞生物学学会会员

2. 中国生物化学与分子生物学学会会员


主要科研奖励和个人荣誉

1. 高等教育(研究生)国家级教学成果奖二等奖

2. 国家级一流本科课程负责人

3. 国家虚拟仿真实验教学项目负责人

4. 武汉大学2017-2018学年本科优秀教学业绩奖

5. 武汉大学2016-2018年度优秀工会工作者


教学情况

1. 本科生:免疫学实验;生物检测技术;分子生物学;细胞生物学;人体及动物生理学

2. 研究生:病毒与细胞的关系;细胞生物学研究前沿


主要研究领域及兴趣

1. 肿瘤发生发展机制研究

2. 细胞外囊泡(外泌体)在肿瘤诊断治疗中的功能与应用基础研究

3. 青藏高原特色藏药材和微生物资源调查及其保护利用研究


主持课题项目

1. 西藏自治区中央引导地方科技发展资金项目(区域创新体系建设)(XZ202301YD0040C),2023-2024

2. 国家自然科学基金地区科学基金项目(32260173),2023-2026

3. 国家自然科学基金面上项目(31871427),2019-2022

4. 湖北省自然科学基金面上项目(2018CFB548),2018-2019

5. 国家自然科学基金应急管理项目(31741081),2018-2018

6. 中央高校基本科研业务费专项资金(学科交叉类资助项目)(2042014kf0243),2014-2015

7. 深圳市科技创新委员会知识创新计划基础研究项目(JCYJ20140419141154250),2014-2016

8. 国家自然科学基金面上项目(31271511),2013-2016

9. 国家自然科学基金面上项目(30871245),2009-2011

10. 教育部高校博士点基金新教师项目(200804861004),2009-2011


主要研究论文(#Co-first author,*Corresponding author,按发表时间排序)

1. Jiaqi Liu#, Yuting Sun#, Xianhuang Zeng#, Yang Liu, Chaozhi Liu, Ying Zhou, Yueguang Liu, Guihong Sun*, Mingxiong Guo*. Engineering and Characterization of an Artificial Drug-carrying Vesicles Nanoplatform for Enhanced Specifically Targeted Therapy of Glioblastoma. Advanced Materials, 2023, 35(41): 2303660.
2. Yi Liu, Wei Yin, Xianhuang Zeng, Jinhao Fan, Chaozhi Liu, Mingyu Gao, Zan Huang, Guihong Sun, Mingxiong Guo*. TBK1-stabilized ZNF268a recruits SETD4 to methylate TBK1 for efficient interferon signaling. Journal of Biological Chemistry, 2023, 299(12): 105428.
3. Sen Yuan#, Jiaqi Xu#, Min Wang#, Junsong Huang, Shuangshuang Ma, Yang Liu, Yujia Ke, Xianhuang Zeng, Kangwei Wu, Jingwen Wang, Xuezhang Tian, Dandan Zheng, Tanzeel Yousaf, Wajeeha Naz, Junwei Sun, Lang Chen, Deyin Guo, Mingxiong Guo*, Guihong Sun*. HBV X protein induces degradation of UBXN7, a novel negative regulator of NF-κB signaling, to promote HBV replication. Cellular and Molecular Gastroenterology and Hepatology, 2023, 15(1): 179-195.
4. Xianhuang Zeng, Chaozhi Liu, Jinhao Fan, Jiabin Zou, Mingxiong Guo*, Guihong Sun*. RNF138 downregulates antiviral innate immunity by inhibiting IRF3 activation. International Journal of Molecular Sciences, 2023, 24(22), 16110.
5. Chuang Li, Wei Wang, Yuting Sun, Yifan Ni, Fang Qin, Xiaolu Li, Tao Wang, Mingxiong Guo*, Guihong Sun*. Selective sorting and secretion of hY4 RNA fragments into extracellular vesicles mediated by methylated YBX1 to promote lung cancer progression. Journal of Experimental & Clinical Cancer Research, 2022, 41(1), 136.
6. Yang Liu#, Jingwen Wang#, Jianwen Chen#, Shaoshuai Wu#, Xianhuang Zeng, Qiushuang Xiong, Yandan Guo, Junwei Sun, Feifei Song, Zhepeng Liu, Fengxing Huang, Jiaqi Xu, Sen Yuan, Chuang Li, Shuting Guo, Ming Wang, Kun Li, Lang Chen, Yun-Bo Shi, Mingxiong Guo*, Deyin Guo*, Guihong Sun*. Upregulation of miR-520c-3p by HBV Enhances Tumor Cell Migration and Invasion by Activating NF-κB Signaling via PTEN-AKT Pathway. Molecular Therapy-Nucleic Acids, 2022, 29: 47-63.
7. Chuang Li#, Fang Qin#, Wei Wang, Yifan Ni, Mingyu Gao, Mingxiong Guo*, and Guihong Sun*. hnRNPA2B1-mediated extracellular vesicles sorting of miR-122-5p potentially promotes lung cancer progression. International Journal of Molecular Sciences, 2021, 22(23), 12866.
8. Chuang Li, Fang Qin, Mengmeng Xue, Yucong Lei, Fen Hu, Hui Xu, Guihong Sun, Tao Wang*, Mingxiong Guo*. miR-429/-424-5p inhibit cell proliferation and Ca2+ influx by targeting CASR in pulmonary artery smooth muscle cells. American Journal of Physiology-Cell Physiology, 2019, 316(1): C111-C120.
9. Yi Liu, Wei Yin, Jingwen Wang, Yucong Lei, Guihong Sun, Wenxin Li, Zan Huang*, Mingxiong Guo*. KRAB-zinc finger protein ZNF268a deficiency attenuates the virus-induced pro-inflammatory response by preventing IKK complex assembly. Cells-Basel, 2019, 8, 1604.
10.
Jingwen Wang, Jianwen Chen, Yang Liu, Xianhuang Zeng, Mingcong Wei, Shaoshuai Wu, Qiushuang Xiong, Feifei Song, Xu Yuan, Yu Xiao, Yun Cao, Changyong Li, Lang Chen, Mingxiong Guo, Yun-Bo Shi, Guihong Sun, Deyin Guo. Hepatitis B Virus Induces Autophagy to Promote its Replication by the Axis of miR-192-3p-XIAP Through NF kappa B Signaling. Hepatology. 2019, 69(3): 974-992.
11. Chuang Li#, Fang Qin#, Fen Hu, Hui Xu, Guihong Sun, Guang Han, Tao Wang*, Mingxiong Guo*. Characterization and selective incorporation of small non-coding RNAs in non-small cell lung cancer extracellular vesicles. Cell and Bioscience, 2018, 8: 2.
12. Mingyang He, Weiwei Zhou, Chuang Li, Mingxiong Guo*. MicroRNAs, DNA Damage Response, and Cancer Treatment. International Journal of Molecular Sciences, 2016, 17(12): 2087.
13. Mingyang He, Yi Lin, Yunlan Tang, Yi Liu, Weiwei Zhou, Chuang Li, Guihong Sun*, Mingxiong Guo*. miR-638 suppresses DNA damage repair by targeting SMC1A expression in terminally differentiated cells. Aging-US, 2016, 8(7): 1442-1456.
14. Zhirong Bao#, Mingyang He#, Hong Quan*, Dazhen Jiang, Yanhong Zheng, Wenjing Qin, Yunfeng Zhou, Feng Ren, Mingxiong Guo* and Changzhong Jiang*. FePt nanoparticles: a novel nanoprobe for enhanced HeLa cells sensitivity to chemoradiotherapy. RSC advances, 2016, 6, 35124-34.
15. Yunlan Tang, Yi Lin,
Chuang Li, Xunwu Hu, Yi Liu, Mingyang He, Jun Luo, Guihong Sun, Tao Wang, Wenxin Li, Mingxiong Guo*. MicroRNA-720 promotes in vitro cell migration by targeting Rab35 expression in cervical cancer cells. Cell and Bioscience, 2015, 5: 56.
16. Yi Lin, Dengju Li, Qing Liang, Shangqing Liu, Xuelan Zuo, Lin Li, Xuemei Sun, Wenxin Li, Mingxiong Guo*, Zan Huang*. miR-638 regulates differentiation and proliferation in leukemic cells by targeting cyclin-dependent kinase 2.
Journal of Biological Chemistry, 2015, 290(3): 1818-1828.
17.
Hongmei Cui, Mingxiong Guo, Dong Xu, Zhi-Chun Ding, Gang Zhou, Han-Fei Ding, Junran Zhang, Yi Tang & Chunhong Yan. The stress-responsive gene ATF3 regulates the histone acetyltransferase Tip60. Nature Communications, 2015, 6:6752
18. Wei Wang, Jinyang Cai, Yi Lin, Zikou Liu, Qihao Ren, Li Hu, Zan Huang, Mingxiong Guo*, and Wenxin Li*. Zinc Fingers Function Cooperatively with KRAB Domain for Nuclear Localization of KRAB-containing Zinc Finger Proteins. PLoS One, 2014, 9(3): e92155.
19. Yi Lin, Yan Zeng, Fan Zhang, Lu Xue, Zan Huang, Wenxin Li*, Mingxiong Guo*. Characterization of MicroRNA Expression Profiles and the Discovery of Novel MicroRNAs Involved in Cancer during Human Embryonic Development. PLoS One, 2013, 8(8): e69230.
20. Wei Wang, Jinyang Cai, Yingliang Wu, Jun Hu, Zongyun Chen, Wenxin Li, Mingxiong Guo*, Zan Huang*. Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB‑containing zinc finger proteins by interacting with KAP1. Cellular and Molecular Life Sciences, 2013, 70(20): 3947-3958.
21. Li Hu
#, Wei Wang#, Jinyang Cai, Jun Luo, Yi Huang, Shilu Xiong, Wenxin Li, Mingxiong Guo*. Aberrant expression of ZNF268 alters the growth and migration of ovarian cancer cells. Oncology letters, 2013, 6: 49-54.
22. Wei Wang
#, Mingxiong Guo#, Li Hu, Jinyang Cai, Yan Zeng, Jun Luo, Zhiqiang Shu, Wenxin Li, Zan Huang. The Zinc Finger Protein ZNF268 is Overexpressed in Human Cervical Cancer and Contributes to Tumorigenesis via Enhancing NF-κB Signaling. Journal of Biological Chemistry, 2012, 287(51): 42856-66.
23. Yan Zeng, Wei Wang, Jian Ma, Xianguo Wang, Mingxiong Guo*
, Wenxin Li*. Knockdown of ZNF268, Which Is Transcriptionally Downregulated by GATA-1, Promotes Proliferation of K562 Cells. PLoS One, 2012, 7(1): e29518.
24. Hong Yi
#, Lu Xue#, Ming-Xiong Guo#, Jian Ma, Yan Zeng, Wei Wang, Jin-Yang Cai, Hai-Ming Hu, Hong-Bing Shu, Yun-Bo Shi, Wen-Xin Li. Gene Expression Atlas for Human Embryogenesis. FASEB Journal, 2010, 24(9): 3341-50.
25. Zhouzhou Zhao, Di Wang, Chengang Zhu, Huanjie Shao, Chong Sun, Hongling Qiu, Lu Xue, Junhua Xu, Mingxiong Guo*, Wenxin Li*. Aberrant alternative splicing of human zinc finger gene ZNF268 in human hematological malignancy. Oncology Reports, 2008, 20(5): 1243-8.
26. Di Wang#, Ming-Xiong Guo#, Zhou-Zhou Zhao, Hong-Ling Qiu, Hai-Ming Hu, Huan-Jie Shao, Chen-Gang Zhu, Lu Xue, Yun-Bo Shi and Wen-Xin Li. Human T-cell leukemiavirus type 1 oncoprotein tax represses ZNF268 expression through the cAMP-responsive Element-binding Protein/Activating Transcription Factor pathway. Journal of Biological Chemistry, 2008, 283(24): 16299-308.
27.
Mingxiong Guo, Tao Huang, Yejian Cui, Baiqun Pan, Ao Shen, Yuting Sun, Yourong Yi, Yan Wang, Gengfu Xiao, Guihong Sun. PrPC interacts with tetraspanin-7 through bovine PrP154-182 containing alpha-helix 1. Biochemical and Biophysical Research Communications, 2008, 365(1): 154-7.

28. Ming-Xiong Guo#, Di Wang#, Huan-Jie Shao, Hong-Ling Qiu, Lu Xue, Zhou-Zhou Zhao, Chen-Gang Zhu, Yun-Bo Shi, and Wen-Xin Li. Transcription of Human Zinc Finger ZNF268 Gene Requires an Intragenic Promoter Element. Journal of Biological Chemistry, 2006, 281(34): 24623-36.




职称 教授 实验室地址 武汉大学生命科学学院4019室
联系电话 13343469985 Email guomx@whu.edu.cn
入选时间 学科专业 细胞生物学
研究方向 肿瘤细胞生物学/微生物生态学

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