黄 赞博士、教授/PhD, Professor

学科专业

生物化学与分子生物学/Biochemistry and Molecular Biology

研究方向

巨核细胞生成与核内有丝分裂;白血病与肝癌发生/ Megakaryopoiesis & Endomitosis; Leukemogenesis & Hepatocarcinogenesis

实验室位置

生命科学学院5020、5131室

联系电话

86-27-68756660

Email

z-huang@whu.edu.cn

教育经历/Education

武汉大学 学士/ Wuhan University Bachelor

武汉大学 硕士/Wuhan University Master

芝加哥洛约拉大学 博士/Loyola University Chicago, PhD

美国芝加哥大学肿瘤研究所 博士后/ University of Chicago Ben May Institute for Cancer Research Post-doctoral Fellow

美国西北大学医学院 博士后/Northwestern University Feinberg School of Medicine Post-doctoral Fellow



工作经历/Professional experience

上海市儿童医院 研究助理/Children’s Hospital of Shanghai Research Associate

Loyola University Chicago 研究助理/Research Associate

武汉大学生命科学学院 教授/ Wuhan University College of Life Sciences Professor



社会兼职/Professional Affiliation

美国血液学学会/American Society of Hematology

亚太医学生物免疫学会基础免疫学分会委员

湖北省医学生物免疫学会血液学分会学术委员会副主任

中国细胞生物学学会/Chinese Society for Cell Biology

中国生理学学会/Chinese Association for Physiological Sciences


主要研究方向

1)巨核细胞生成和血液肿瘤发生机制与干预:研究调控巨核细胞生成和多倍体化中的信号转导、转录调控、表观遗传机制,以及相关异常造成骨髓增殖性肿瘤(原发性骨髓纤维化)发生的分子基础和靶向干预;阐明急性髓系白血病细胞增殖、存活和恶变的关键因素,研发新的治疗策略。

2)肝脏病变与肝癌发生机理:阐释非酒精性肝脏脂肪变性、非酒精性脂肪肝炎、肝硬化到肝癌演化发生的分子机制;特别关注天然免疫、泛素化/去泛素与代谢的功能。

Research topics:

1. Megakaryopoiesis and hematopoietic malignancies (pathogenesis and intervention): We investigate signaling, transcriptional, and epigenetic mechanisms controlling megakaryopoiesis and polyploidiazation and explore molecular basis how these abnormalities cause myeloproliferative neoplasms particularly Primary Myelofibrosis that can be used for target intervention. We also aim to identify key regulators controlling acute myeloid leukemia cell proliferation, survival, and malignant transformation for development of novel therapeutic strategy.

2.Pathogenesis of liver diseases and hepatocellular carcinoma: We dissect molecular mechanism underlying the progressive evolution of Non-alcoholic Fatty Liver Disease (NAFLD), Non-alcoholic Steatohepatitis (NASH), Cirrhosis to Hepatocellular Carcinoma; particularly focus on the function of innate immunity, ubiquitination/deubiquitination, and metabolism in these diseases.


教学课程/Course director

本科生:生物化学/Biochemistry for undergraduates

研究生:造血细胞发育与分化/Hematopoiesis for graduates


主持课题项目/Funding

1. 国自然青年科学基金项目(项目编号:30700412;2008-2010;主持)

2. 国自然面上项目(编号:81070406;2011-2013;主持)

3. 国自然面上项目(编号:31371481;2014-2017;主持)

4. 国自然面上项目(编号:81670140;2018-2021;主持)

5. 国自然面上项目(编号:81870427;2019-2022;主持)

6. 国自然重大研究计划(培育)(编号:91957109;2020-2022;主持)

7. 国自然面上项目(编号:32270643;2023-2026;主持)

8. 教育部博士点基金(编号:20110141110016;2012-2014;主持)

9. 教育部回国留学人员启动基金(2012;主持)

10. 教育部“新世纪优秀人才支持计划”(编号:NCET-12-0422;2013-2015;主持)


发表论文(#并列第一作者*通讯作者)/Selected Publications

1. Jiaqi Sun, Xiyang Wang, Qingsong Shen, Min Wang, Shuxian Chen, Xuechun Zhang, Yongping Huang, Zhonglin Zhang, Wenhua Li, Yufeng Yuan;, Zan Huang; DNASE1L3 inhibits hepatocellular carcinoma by delaying cell cycle progression through CDK2. Cellular Oncology, Accepted
2. Hu, Yufeng#; He, Wenzhi#; Huang, Yongping#; Xiang, Hui; Guo, Juan; Che, Yan; Cheng, Xu; Hu, Fengjiao; Hu, Manli; Ma, Tengfei; Yu, Jie; Tian, Han; Tian, Song; Ji, Yan-Xiao; Zhang, Peng; She, Zhi-Gang; Zhang, Xiao-Jing; Huang, Zan*; Yang, Juan*; Li, Hongliang*; Fatty Acid Synthase-Suppressor Screening Identifies Sorting Nexin 8 as a Therapeutic Target for NAFLD. Hepatology, 2021, 74(5): 2508-2525.
3. Yan, Zhen-Zhen#; Huang, Yong-Ping#; Wang, Xin#; Wang, Hai-Ping; Ren, Fei; Tian, Rui-Feng; Cheng, Xu; Cai, Jie; Zhang, Yan; Zhu, Xue-Yong; She, Zhi-Gang; Zhang, Xiao-Jing; Huang, Zan*; Li, Hongliang*; Integrated Omics Reveals Tollip as an Regulator and Therapeutic Target for Hepatic Ischemia-Reperfusion Injury in Mice., Hepatology, 2019, 70(5): 1750-1769.
4. Yang, Xuejing#; Lu, Bin#; Sun, Xueqin#; Han, Cuijuan; Fu, Chunling; Xu, Kailin; Wang, Min; Li, Dengju; Chen, Zhichao; Opal, Puneet; Wen, Qiang; Crispino, John D; Wang, Qian-Fei*; Huang, Zan*; ANP32A regulates histone H3 acetylation and promotes leukemogenesis. Leukemia, 2018, 32(7): 1587-1597.
5. Ji YX#, Huang Z#, Yang X#, Wang X#, Zhao LP, Wang PX, Zhang XJ, Alves-Bezerra M, Cai L, Zhang P, Lu YX, Bai L, Gao MM, Zhao H, Tian S, Wang Y, Huang ZX, Zhu XY, Zhang Y, Gong J, She ZG, Li F, Cohen DE & Li H. The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis. Nat Med. 2018.
6. Yan FJ, Zhang XJ, Wang WX, Ji YX, Wang PX, Yang Y, Gong J, Shen LJ, Zhu XY, Huang Z* & Li H*. The E3 ligase tripartite motif 8 targets TAK1 to promote insulin resistance and steatohepatitis. Hepatology. 2017;65(5):1492-1511.
7. Wang X, Mao W, Fang C, Tian S, Zhu X, Yang L, Huang Z* & Li H*. Dusp14 protects against hepatic ischaemia-reperfusion injury via Tak1 suppression. J Hepatol. 2017.
8. Lu B, Ren Y, Sun X, Han C, Wang H, Chen Y, Peng Q, Cheng Y, Cheng X, Zhu Q, Li W, Li HL, Du HN, Zhong B*, Huang Z*. Induction of INKIT by Viral Infection Negatively Regulates Antiviral Responses through Inhibiting Phosphorylation of p65 and IRF3. Cell Host Microbe. 2017;22(1):86-98 e84.
9. Yan FJ, Zhang XJ, Wang WX, Ji YX, Wang PX, Yang Y, Gong J, Shen LJ, Zhu XY, Huang Z*, Li H*. The E3 ligase tripartite motif 8 targets TAK1 to promote insulin resistance and steatohepatitis. Hepatology. 2017;65(5):1492-1511.
10. Jin Q, Ren Y, Wang M, Suraneni PK, Li D, Crispino JD, Fan J*, Huang Z*. Novel function of FAXDC2 in megakaryopoiesis. Blood Cancer J. 2016;6(9):e478.
11. Lu B, Sun X, Chen Y, Jin Q, Liang Q, Liu S, Li Y, Zhou Y, Li W, Huang Z*. Novel function of PITH domain-containing 1 as an activator of internal ribosomal entry site to enhance RUNX1 expression and promote megakaryocyte differentiation. Cellular and Molecular Life Sciences: CMLS. 2015. 72(4): 821-832
12. Lin Y, Li D, Liang Q, Liu S, Zuo X, Li L, Sun X, Li W, Guo M*, Huang Z*. miR-638 Regulates Differentiation and Proliferation in Leukemic Cells by Targeting Cyclin-dependent Kinase 2.  J Biol Chem. 2015. 290(3): 1818-1828
13. Sun X, Lu B, Hu B, Xiao W, Li W, Huang Z#. Novel function of the chromosome 7 open reading frame 41 gene to promote leukemic megakaryocyte differentiation by modulating TPA-induced signaling. Blood Cancer J.2014. 4: e198
14. Liu L, Wen Q, Gong R, Gilles L, Stankiewicz MJ, Li W, Guo M, Li L, Sun X, Crispino JD, Huang Z*. PSTPIP2 dysregulation contributes to aberrant terminal differentiation in GATA-1-deficient megakaryocytes by activating LYN. Cell Death & Disease. 2014. 5: e988
15. Wang W, Cai J, Wu Y, Hu L, Chen Z, Hu J, Li W, Guo M*, Huang Z*. Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1. Cellular and Molecular Life Sciences: CMLS.2013. 70(20): 3947-3958
16. Khan I#, Huang Z#, Wen Q, Stankiewicz MJ, Gilles L, Goldenson B, Schultz R, Diebold L, Gurbuxani S, Finke CM, Lasho TL, Koppikar P, Pardanani A, Stein B, Altman JK, Levine RL, Tefferi A, Crispino JD. AKT is a therapeutic target in myeloproliferative neoplasms. Leukemia.2013. 27(9): 1882-1890
17. Wen Q, Goldenson B, Silver SJ, Schenone M, Dancik V, Huang Z, Wang LZ, Lewis TA, An WF, Li X, Bray MA, Thiollier C, Diebold L, Gilles L, Vokes MS, Moore CB, Bliss-Moreau M, Verplank L, Tolliday NJ, Mishra R, Vemula S, Shi J, Wei L, Kapur R, Lopez CK, Gerby B, Ballerini P, Pflumio F, Gilliland DG, Goldberg L, Birger Y, Izraeli S, Gamis AS, Smith FO, Woods WG, Taub J, Scherer CA, Bradner JE, Goh BC, Mercher T, Carpenter AE, Gould RJ, Clemons PA, Carr SA, Root DE, Schreiber SL, Stern AM, Crispino JD. Identification of Regulators of Polyploidization Presents Therapeutic Targets for Treatment of AMKL. Cell.2012. 150(3): 575-589
18. Wang W, Guo M, Hu L, Cai J, Zeng Y, Luo J, Shu Z, Li W*, Huang Z*. The zinc finger protein ZNF268 is overexpressed in human cervical cancer and contributes to tumorigenesis via enhancing NF-kappaB signaling. J Biol Chem.2012. 287(51): 42856-42866
19. Huang Z, Dore LC, Li Z, Orkin SH, Feng G, Lin S, Crispino JD. GATA-2 reinforces megakaryocyte development in the absence of GATA-1. Mol Cell Biol. 2009;29(18):5168-5180.
20. Huang Z, Richmond TD, Muntean AG, Barber DL, Weiss MJ, Crispino JD. STAT1 promotes megakaryopoiesis downstream of GATA-1 in mice. J Clin Invest. 2007;117(12):3890-3899.


专利/Patent

1. Dimethyl fasudil for inducing polyploidization of megakaryocytes and for treating blood and bone marrow diseases and disorders. John D. Crispino; Qiang Wen; Zan Huang; Andrew M. Stern; Robert J. Gould. 2015-1-13, 美国, 8933071
2. miR-638在抗急性髓系白血病中的应用;李文鑫、郭明雄、黄赞、林义; 2016-9-28, 中国, CN104208723A
3. 用于制备肝癌检测试剂的新型代谢标志物及其应用;黄赞、孙佳琪;2022.07.29,中国,CN114814001A
4. 用于制备治疗肝癌药物的新型代谢标志物及其应用;黄赞、孙佳琪;2022.07.29,中国,CN114807289A
5. 用于制备治疗肝癌药物的代谢物及其应用;黄赞、孙佳琪;2022.05.24,中国,CN114522158A
6. 靶向ANP32A抗白血病的小分子肽及其制备方法和应用;黄赞、王曼曼、张昙;2021.09.03,中国,CN113336829A

职称 博士、教授/PhD, Professor 实验室地址 生命科学学院5020、5131室
联系电话 86-27-68756660 Email z-huang@whu.edu.cn
入选时间 学科专业 生物化学与分子生物学/Biochemistry and Molecular Biology
研究方向 巨核细胞生成与核内有丝分裂;白血病与肝癌发生/ Megakaryopoiesis & Endomitosis; Leukemogenesis & Hepatocarcinogenesis

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